Relationship of volumetric bone mineral density by quantitative computed tomography with abdominal aortic calcification

Li, Sidong; Lu, Yin; Li, Kai; Hu, Bo; Wang, Ling; Wang, Yan; Li, Ning; You, Kai; Yu, Li; Liu, Guoqin; Xu, Shaoqi; Zhu, Lei; Shao, Jiman; Hao, Xiaoyan; Zhou, Jun; Cheng, Xiaoguang; Li, Wei

doi:10.1016/j.bone.2020.115226

Cited by 13 publications

(11 citation statements)

References 55 publications

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“…( 56 ) In some studies, older men with severe AAC had lower aBMD and poor bone microarchitecture, mainly in the trabecular bone. ( 8,10,17–20,57 ) In our study, severe AAC was associated with higher risk of MACE, also after adjustment for confounders. However, addition of AAC in the model had a weak impact on the associations between bone variables and the risk of MACE.…”

Section: Discussionsupporting

confidence: 58%

High Cardiovascular Risk in Older Men with Poor Bone Microarchitecture—The Prospective STRAMBO Study

Szulc

Foesser

Chapurlat

2020

Journal of Bone and Mineral Research

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Data on the association between bone microarchitecture and cardiovascular disease (CVD) in men are scarce. We studied the link of bone microarchitecture and areal bone mineral density (aBMD) with the risk of major adverse coronary event (MACE) in a cohort of men aged 60 to 87 years followed prospectively for 8 years. At baseline, aBMD was measured using a Hologic Discovery‐A device. Bone microarchitecture was assessed at distal radius and tibia by high‐resolution peripheral quantitative computed tomography (XtremeCT Scanco device). During the study, 53 men had incident MACE. The analyses were adjusted for confounders related to bone and CVD. In 813 men (53 MACEs), higher aBMD at the lumbar spine, hip, whole body, and radius was associated with lower risk of MACE (hazard ratio [HR] = 0.44–0.71/SD, p < .025 to < .001). In 745 men having valid distal radius scan (47 MACEs), higher cortical density (Ct.BMD) and higher cortical thickness (Ct.Thd) were associated with lower risk of MACE. This risk was higher in men in the lowest quintile of cortical measures versus the four upper quintiles combined (Ct.BMD: HR = 2.12, 95% confidence interval [CI] 1.08–4.17, p < .025). Findings were similar in 779 men having valid distal tibia scan (48 MACEs). At both sites, higher estimated stiffness and higher failure load were associated with a lower risk of MACE. The risk of MACE was higher in men in the lowest quintile of the measures of bone strength versus four upper quintiles jointly (distal radius stiffness: HR = 2.46, 95% CI 1.27–4.74, p < .01). Similar results were obtained in 638 men without prior fragility fracture and in 689 men without ischemic heart disease at baseline. Thus, in older men followed prospectively for 8 years, higher aBMD, preserved cortical bone status, and higher estimated bone strength were associated with lower risk of MACE after adjustment for relevant confounders. © 2021 American Society for Bone and Mineral Research (ASBMR).

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Section: Discussionsupporting

confidence: 58%

High Cardiovascular Risk in Older Men with Poor Bone Microarchitecture—The Prospective STRAMBO Study

Szulc

Foesser

Chapurlat

2020

Journal of Bone and Mineral Research

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“…Age-related pathological ndings, such as osteophytes, facet hyperplasia, endplate sclerosis, and aortic calci cation, are more prominent in the LS than in the FN. [10][11][12][13] In contrast, FN BMD is affected by osteoarthritis of the hip joint. 14 Yoshimura et al reported that the prevalence of advanced-stage hip arthrosis was 3.5% (men, 1.0%; women, 6.1%), which is much lower than that of degenerative lumbar spondylosis.…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Spine–Femur Discordance in The Percentage of Young Adult Mean On Dual-Energy X-Ray Absorptiometry in The Elderly Population: A Retrospective Study

Akiyama

Tanaka

Udaka

et al. 2021

Preprint

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Background Several retrospective studies have reported spine–femur discordance in bone mineral density (BMD) values. However, the average age of individuals in these studies was the mid-50s, which is younger than the typical age of individuals requiring treatment for primary osteoporosis. Therefore, we aimed to investigate factors associated with discordance in the percentage of young adult mean (YAM) between the lumbar spine and femoral neck in the elderly population. Methods We evaluated 4549 dual-energy X-ray absorptiometry (DXA) measurements obtained from 2161 patients (269 men and 1892 women) between January 2014 and December 2017 at our hospital. For individuals with more than one eligible set of measurements, the first record was used. We investigated each patient’s age, sex, body mass index, current smoking status, alcohol consumption, use of steroids, presence of diabetes mellitus, and presence of rheumatoid arthritis. Results The mean age of the patients was 76.4 ± 8.9 years. Older age (p < 0.001), male sex (p < 0.001), and diabetes mellitus (p = 0.007) were significantly associated with spine–femur discordance in the percentage of YAM. Conclusion The frequency and magnitude of spine–femur discordance in the percentage of YAM from DXA scans increased with age. Notably, more than 77.36% of patients in their 90s had spine–femur discordance > 10% of YAM. Furthermore, the frequency of spine–femur discordance was higher in men and in patients with diabetes mellitus, suggesting that the percentage of YAM at the lumbar spine may not be reliable for diagnosis of osteoporosis in patients with these factors.

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“…Notably, 58.5% of patients in their 80s and 77.4% of those in their 90s had a spine–femur discordance rate of > 10% of YAM (group A). Age-related pathological findings, such as osteophytes, facet hyperplasia, endplate sclerosis, and aortic calcification, are more prominent in the LS than in the FN [ 11 – 14 ]. In contrast, FN BMD is affected by osteoarthritis of the hip joint [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Factors affecting spine–femur discordance in the percentage of young adult mean on dual-energy X-ray absorptiometry in the elderly population: a retrospective study

Akiyama

Tanaka

Udaka

et al. 2022

BMC Musculoskelet Disord

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Background Several retrospective studies have reported spine–femur discordance in bone mineral density (BMD) values. However, the average age of individuals in these studies was the mid-50s, which is younger than the typical age of individuals requiring treatment for primary osteoporosis. Therefore, we aimed to investigate factors associated with discordance in the percentage of young adult mean (YAM) between the lumbar spine and femoral neck in the elderly population. Methods We evaluated 4549 dual-energy X-ray absorptiometry (DXA) measurements obtained from 2161 patients (269 men and 1892 women) between January 2014 and December 2017 at our hospital. For individuals with more than one eligible set of measurements, the first record was used. We investigated each patient’s age, sex, body mass index, current smoking status, alcohol consumption, use of steroids, presence of diabetes mellitus, and presence of rheumatoid arthritis. Results The mean age of the patients was 76.4 ± 8.9 years. Older age (p < 0.001), male sex (p < 0.001), and diabetes mellitus (p = 0.007) were significantly associated with spine–femur discordance in the percentage of YAM. Conclusion The frequency and magnitude of spine–femur discordance in the percentage of YAM from DXA scans increased with age. Notably, more than 77.4% of patients in their 90s had spine–femur discordance > 10% of YAM. Furthermore, the frequency of spine–femur discordance was higher in men and in patients with diabetes mellitus, suggesting that the percentage of YAM at the lumbar spine may not be reliable for diagnosis of osteoporosis in patients with these factors.

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Relationship of volumetric bone mineral density by quantitative computed tomography with abdominal aortic calcification

Cited by 13 publications

References 55 publications

High Cardiovascular Risk in Older Men with Poor Bone Microarchitecture—The Prospective STRAMBO Study

High Cardiovascular Risk in Older Men with Poor Bone Microarchitecture—The Prospective STRAMBO Study

Factors Affecting Spine–Femur Discordance in The Percentage of Young Adult Mean On Dual-Energy X-Ray Absorptiometry in The Elderly Population: A Retrospective Study

Factors affecting spine–femur discordance in the percentage of young adult mean on dual-energy X-ray absorptiometry in the elderly population: a retrospective study

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