Relationships between avian exposure, humoral immune response, and pigeon breeders' disease among Scottish pigeon fanciers.

Abstract

An association between pigeon breeders' disease and serum IgG antibodies to antigens derived from pigeon has been recognised since the first description of this type of hypersensitivity pneumonitis in 1965.'The relationship between exposure, circulating IgG antibody against pigeon protein antigens, and the development of pigeon breeders' disease remains uncertain,2 however, and this is reflected in the results of clinical studies. Patients reported in detail,3 usually with an acute, severe illness, typically have an intense antibody response and are rarely antibody negative4; whereas surveys conducted among the general population of pigeon fanciers regularly identify people who are apparently affected but who lack serum antibodies.5 6 Furthermore, these studies have found an appreciable proportion of healthy fanciers who do have circulating antibody against pigeon proteins, and it has been suggested that the humoral response largely reflects the intensity of exposure. used a radioimmunoassay technique to investigate the humoral antibody response and the factors which influence this and the development of pigeon breeders' disease in a large group of pigeon fanciers. MethodsPigeon fanciers in Central Scotland were approached through meetings organised at their local pigeon racing clubs and any person regularly exposed to pigeons, whether primarily engaged in the hobby or helping a relative with the pigeon husbandry, was asked to complete a questionnaire and provide a 20 ml venous blood sample. The questionnaire was divided into several sections, the questions generally requiring a simple "yes/no" reply. One section related to the circumstances and degree of exposure, another concerned the presence of any immediate or delayed symptoms after contact with the pigeons, and a further section recorded the details of any other illnesses. The completed questionnaires were coded and the data transferred to the disc storage of a PDPI 1/45 computer. Criteria for extrinsic allergic alveolitis were derived from Christensen et al,6 requiring a delayed (6-12 hours after exposure) respiratory symptom, 274 on 9 May 2018 by guest. Protected by copyright.

Relationships between Exposure to Spores from <i>Rhizopus</i> <i>microsporus</i> and <i>Paecilomyces variotii</i> and Serum IgG Antibodies in Wood Trimmers

“…The antigens can be found in the work ing environments of these patients, such as farms [1,2] and sawmills [3], and working environments with contami nated humidifiers [4,5]. Exposure may also occur in lei sure time due to activities such as pigeon breeding [6,7]. In sawmills, wood trimmers are exposed to mould spores when they handle mouldy timber.…”

Health hazard evaluation report: HETA #2002-0155-2886, DaimlerChrysler Transmission Plant, Kokomo, Indiana.

“…For example, elevated levels of antibody against purified avian antigens have been associated with increased incidence of pigeon breeders disease (a form of HP), 24 and increasing exposure to pigeons has been associated with increase in antibody response to pigeon antigens. 25 We also found increased level of antibody against Fusarium (isolated from parts washers at ITP) among persons with HP (but not among persons exposed to MWF). As with other antibody testing, our antibody testing was non-specific in that we found elevated levels of M. immunogenum and Fusarium antibody in some persons without HP.…”

PENINGKATAN CD8 DAN IFN-γ PADA HYPERSENSITIVITY PNEUMONITIS (HP) AKIBAT PAJANAN DEBU PENGGILINGAN PADI

“…Tiga macam antigen yang menyebabkan HP adalah organisme mikrobiologi (bakteria, jamur dan komponennya), protein hewan, dan bahan kimia dengan berat molekul rendah (Bourke et al, 2001) (Rose dan Lara, 2010). Faktor geografis, sosial dan pekerjaan menentukan tipe khusus HP yang ditemukan di seluruh dunia (Banham, 1986) (Nakazawa dan Tochigi, 1989) (Bourke et al, 2001).…”