Relationships between Toxicopathic Hepatic Lesions and Exposure to Chemical Contaminants in English Sole (Pleuronectes vetulus), Starry Flounder (Platichthys stellatus), and White Croaker (Genyonemus lineatus) from Selected Marine Sites on the Pacific Coast, USA

Myers, Mark S.; Stehr, Carla M.; Olson, O. Paul; Johnson, Lyndal L.; McCain, Bruce B.; Chan, Sin-Lam; Varanasi, Usha

doi:10.2307/3431612

Cited by 45 publications

(70 citation statements)

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“…Other lesion categories, such as non-neoplastic proliferative lesions, unique or specific degenerative/necrotic conditions, nonspecific necrotic lesions not associated with visible infectious agents, intracytoplasmic storage disorders, and vascular lesions, were documented when observed. These lesion categories were consistent with those defined by the NBSP (Malins et al 1987;Myers et al 1994Myers et al , 1999 and similar studies . Other minor lesion categories, such as intracytoplasmic storage disorders and vascular lesions, were documented when observed; however, these were rare.…”

Section: Histopathological Analysessupporting

confidence: 56%

“…Because the majority of specimens selected for examination were large and sexually mature, and the risk of occurrence for these toxicopathic lesions increases with age (e.g., Myers et al 1994), the present results may over-estimate the prevalence of liver lesions for the entire populations of these species within the study area. Conversely, the results were based primarily on assessments of two to three liver tissue sections from each fish, and it is possible that analyses of more sections from each liver sample could yield relatively higher overall lesion prevalence estimates.…”

Section: Discussionmentioning

confidence: 87%

“…The prevalence of certain lesion types in fish livers is positively associated with exposures to chemical contaminants (Au 2004;Myers et al 1994;Stehr et al 1997Stehr et al , 1998. Correlations between liver lesions and contaminated sediments have been described for several fish species from sites on the Pacific coast of the United States, including San Francisco Bay, Los Angeles Harbor, San Diego Bay, and Puget Sound (Malins et al 1987;McCain et al 1992;Myers et al 1993Myers et al , 1994Myers et al , 1999, and other embayments near highly urbanized areas (e.g., Moore et al 1996).…”

Section: Introductionmentioning

confidence: 93%

“…Correlations between liver lesions and contaminated sediments have been described for several fish species from sites on the Pacific coast of the United States, including San Francisco Bay, Los Angeles Harbor, San Diego Bay, and Puget Sound (Malins et al 1987;McCain et al 1992;Myers et al 1993Myers et al , 1994Myers et al , 1999, and other embayments near highly urbanized areas (e.g., Moore et al 1996). Monitoring toxicopathic hepatic lesions in fish, such as neoplasms (NEO), preneoplastic foci of cellular alteration (FCA), and hydropic vacuolation (HYDVAC), can provide potentially important information for evaluating the magnitude and bioavailability of xenobiotic contaminants in the marine environment (Hinton and Lauren 1990;Moore et al 1997;Myers and Fournie 2002).…”

Section: Introductionmentioning

confidence: 96%

“…Previous studies in coastal areas of the Southern California Bight (SCB), including areas affected by sewage discharges, have shown that white croaker were susceptible to effects from xenobiotic contaminants. Adverse responses to chemical contaminants were manifested by elevated concentrations of organochlorines in muscle tissues (e.g., Gossett et al 1983), reproductive impairment (Hose et al 1989), and toxicopathic liver lesions (Malins et al 1987;Myers et al 1994;Stehr et al 1998). Thus, white croaker represents a potentially important sentinel species for evaluating effects from wastewater exposures.…”

Section: Introductionmentioning

confidence: 99%

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Liver lesions in demersal fishes near a large ocean outfall on the San Pedro Shelf, California

Basmadjian

Perkins

Phillips

et al. 2007

Environ Monit Assess

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The prevalence of toxicopathic liver lesions in demersal fish on the San Pedro Shelf, California was determined for a 15-year period (1988-2003). Fish livers were sampled at fixed locations as part of the Orange County Sanitation Districts (OCSD) ocean monitoring program. Histopathological examination of selected fish liver tissues was studied to determine whether the wastewater discharge had affected fish health. The prevalence of toxicopathic lesion classes neoplasms (NEO), preneoplastic foci of cellular alteration (FCA), and hydropic vacuolation (HYDVAC) varied among species and locations. For all species sampled, severe lesions occurred in 6.2% of the fish examined (n=7,694). HYDVAC (4.1%) was the most common toxicopathic lesion type followed by FCA (1.4%) and NEO (0.7%). HYDVAC occurred only in white croaker (Genyonemus lineatus), accounting for 84.8% of the toxicopathic lesions for this species. Prevalence of HYDVAC, NEO, and FCA in white croaker was 15.2, 2.0, and 0.7%, respectively. The prevalence of HYDVAC and NEO in white croaker increased with age and size but there was no sexual difference. A linear regression model was used for hypothesis testing to account for significant differences in fish size (and age for croakers) at the different sampling locations. This analysis showed that for HYDVAC there was no spatial or location effect for lesion rate or size/age of onset. For NEO, the model predicted that white croaker near the wastewater outfall may acquire these lesions at a smaller size/younger age, and at a higher rate, than at other sites. However, this result may be biased due to the unequal size frequency distributions and the low prevalence of NEO in white croaker at the different sampling sites. Bigmouth sole (Hippoglossina stomata) had a prevalence of FCA and NEO of 1.3 and 0.35%, respectively, but the prevalence and distribution of lesions was too few for statistical testing. There was no sexual difference for lesion prevalence in hornyhead turbot (Pleuronichthys verticalis) and the prevalence of FCA and NEO was 3.4 and 0.37%, respectively. FCA prevalence increased with size in hornyhead turbot and there were no significant spatial differences for lesion rates and fish size at lesion onset. Overall, consistent spatial differences for lesion prevalence were not demonstrated and highlight the analytical difficulties of detecting a possible point source impact when the effect is rare, correlated with the size/age structure of the population, and may be caused by exposure to unknown multiple sources. Thus, the usefulness of liver histopathology as a point-source monitoring tool is best applied to where the spatial scale of impact generally exceeds the home range of the target species.

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Section: Histopathological Analysessupporting

confidence: 56%

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Liver lesions in demersal fishes near a large ocean outfall on the San Pedro Shelf, California

Basmadjian

Perkins

Phillips

et al. 2007

Environ Monit Assess

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Molecular/Cellular Processes and the Health of the Individual

Hylland¹,

Feist²,

Thain³

et al. 2003

Effects of Pollution on Fish

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An analysis in support of sediment quality thresholds for polycyclic aromatic hydrocarbons (PAHs) to protect estuarine fish

Johnson

Collier

Stein

2002

Aquatic Conservation

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Under the US Endangered Species Act and the Essential FishHabitat provisions of the Sustainable Fisheries Act, it is the responsibility of the National Marine Fisheries Service (NMFS) to safeguard the health of fish in estuarine and coastal waters.2. This includes assessment of the impacts of exposure to toxic chemicals on fish and their critical habitat.3. This analysis was conducted to assist NMFS resource managers in determining when fish are exposed to potentially harmful concentrations of one of the most common environmental contaminants, polycyclic aromatic hydrocarbons (PAHs).4. Effects thresholds were estimated primarily through segmented regression of site-specific sediment PAH concentrations and associated disease prevalences in a resident fish species, English sole, Pleuronectes vetulus.5. The analyses and supporting data encompass several endpoints, including DNA damage, liver lesions, and impacts on growth and reproduction.6. In general, liver lesion prevalences, DNA adduct levels, and impacts on growth and reproduction were minimal at sediment PAH concentrations at or below 1000 ppb. Above 1000 ppb, there appears to be a substantial increase in the risk of contaminant-related injury to English sole.

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Relationships between Toxicopathic Hepatic Lesions and Exposure to Chemical Contaminants in English Sole (Pleuronectes vetulus), Starry Flounder (Platichthys stellatus), and White Croaker (Genyonemus lineatus) from Selected Marine Sites on the Pacific Coast, USA

Cited by 45 publications

References 0 publications

Liver lesions in demersal fishes near a large ocean outfall on the San Pedro Shelf, California

Liver lesions in demersal fishes near a large ocean outfall on the San Pedro Shelf, California

Molecular/Cellular Processes and the Health of the Individual

An analysis in support of sediment quality thresholds for polycyclic aromatic hydrocarbons (PAHs) to protect estuarine fish

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