Relationships of the platelet aggregate ratio to serum cholesterol concentration, smoking and age

Abstract

SummaryThe platelet aggregate ratio has been found to be decreased in some patients with

Circulating Platelet Aggregates in Diabetes mellitus

“…Quintavalla and Poll con firms our observation of no significant difference be tween the mean platelet aggregate ratios o f'adult-on set' diabetics and controls and extends it by showing that the values of their poorly controlled 'adult-onset" diabetics were significantly lower than those of patients who were better controlled. Their data is al so consistent with other results from our laboratory [1] showing no significant correlation between the platelet aggregate ratio and the serum total cholester ol concentration of 52 men. The plasma concentra tion of nonesterified fatty acids, which may cause or enhance platelet aggregation under some conditions [2] , is usually elevated when diabetes mellitus is poor ly controlled.…”

“…Only few cases have been reported and no specific chromo somal changes or markers have been described in these patients [1][2][3][4]. We report the chromosomal find ings in 2 patients with micromegakaryoblastic leu kaemia and compare them with the known findings in myelofibrosis, CML, and megakaryoblastic leu kaemia.…”

“…To the Editor, The paper 'Platelet Aggregate Ratio in Diabetes mellitus', recently published by Davis et al [1], de serves a few comments, derived from a study per formed by us [2] on correlations between indices of haemostatic function and of lipid metabolism in 92 patients with 'adult-onset' diabetes compared with normal controls and subjects with reduced glucose tolerance, both comparable for age, sex, body weight and other characteristics with the diabetes group.…”

“…To the Editor, Acute megakaryoblastic leukaemia is a rare form of leukaemia usually complicating myelofibrosis or chronic myeloid leukaemia (CML) [1,2]. Only few cases have been reported and no specific chromo somal changes or markers have been described in these patients [1][2][3][4].…”

A Modification of the Wu and Hoak Method for the Determination of Platelet Aggregates and Platelet Adhesion

“…Increased platelet aggregates in patients with transient ischaemic attacks and ischaemic heart disease (15,16,17,18), and also acute myocardial infarction (19) have been observed. PAR has been correlated with serum cholesterol concentration in vascular disease, smoking and age (20). Many other studies using this method have been reviewed recently (6).…”