2018
DOI: 10.1002/alr.22192
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Relative abundance of nasal microbiota in chronic rhinosinusitis by structured histopathology

Abstract: Background: Chronic rhinosinusitis (CRS) is an inflammatory disease process with several different phenotypes. Recent data has shown that CRS phenotypes maintain distinct nasal microbiota that may predict surgical outcomes. Nasal microbiota and structured histopathologic reporting have the potential to further differentiate subtypes and provide additional insight into the pathophysiology of CRS. Methods:Sinus swabs collected during functional endoscopic sinus surgery (FESS) were studied by polymerase chain rea… Show more

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Cited by 27 publications
(24 citation statements)
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“…Proteobacteria and Firmicutes were detected as the predominant phyla in the respiratory microbiota of horses [5]. Proteobacteria was associated with increased inflammation and respiratory tract diseases [4]. Noticeably, the proportion of the family Pasteurellaceae was partly responsible for the high amount of Proteobacteria, which demonstrated an evident increase (median: BN 15.9% to AN 30.3%).…”
Section: Discussionmentioning
confidence: 95%
See 1 more Smart Citation
“…Proteobacteria and Firmicutes were detected as the predominant phyla in the respiratory microbiota of horses [5]. Proteobacteria was associated with increased inflammation and respiratory tract diseases [4]. Noticeably, the proportion of the family Pasteurellaceae was partly responsible for the high amount of Proteobacteria, which demonstrated an evident increase (median: BN 15.9% to AN 30.3%).…”
Section: Discussionmentioning
confidence: 95%
“…Although other species are also being investigated, most nasal microbiota studies have been conducted in humans. For example, distinct histopathologic features of chronic rhinosinusitis are associated with the relative abundance of nasal microbiota phyla, specifically Firmicutes and Bacteroidetes [ 4 ]. Pulmonary, oral, and nasal microbiomes in horses are influenced by environmental conditions and are associated with health and mild-moderate equine asthma [ 5 ].…”
Section: Introductionmentioning
confidence: 99%
“…Fusobacteria , for example, are associated with suppuration, which can cause anaerobic conditions in the paranasal cavities [29, 176] (Table 2; Additional file 1). Additionally, the severity of inflammation was positively correlated with the phylum Bacteroidetes (e.g., Prevotella ) and the phylum Proteobacteria ( Pseudomonas ) in CRS [179].…”
Section: Correlations Between the Upper Respiratory Tract Microbiome mentioning
confidence: 99%
“…However, the significant difference in these 2 ethnic populations is not explained in the study. Kuhar et al . report on a study that attempts to correlate structured histopathology reports to bacterial diversity and bacterial phyla.…”
mentioning
confidence: 99%