RELATIVE TRANSLOCATION AND DISTRIBUTION OF Pu AND Am FROM EXPERIMENTAL PuO$sub 2$ SUBCUTANEOUS IMPLANTS IN BEAGLES.

Lymph transport of ²³⁹PuO₂ in dogs

“…These data are shown in Figure 7. The rapid translocation r : Johnson(1969) and Bistline et aL , (1972 b).…”

“…Reports describing the uncertainties in calculating Pu body burdens from urine analysis have been published (Snyder, 1962;Hammond and Putzier, 1964;Beach etaL, 1966;Jech et .al·, 1972 has been shown to be inaccurate ( Taylor, 1962;Hammond ·et ·, 1968;Johnson, 1969;Johnson et&1·, 1970;Watters and Lebel, 1972 are about four x-rays produced for every 100 alpha particles emitted.…”

“…The anatomy of the lymphatic system in the dog's forelimbs and hindlimbs was studied because observations made in previous experiments at this laboratory have shown that individual dogs may have elevated Pu burdens in the axillary lymph node while other dogs contain a very small burden in this node (Johnson, 1969). No explanation of this difference in Pu translocation was made in the past.…”

“…beyond intact lymph nodes ·to more radiosenstivie tissues has been shown to occur (Johnson, 1969;Bistline EL el:, 1972 a, b) Sanders (1972) and Sanders and Jackson (1972) have described phagocytosis of Pu 2 particles by macrophages. The acellular lymph fraction, which contained about one-third of the rapidly translocated Pu, was analyzed by disc electrophoresis to determine the transport mechanism of Pu 2 in lymph.…”

Translocation dynamics of 239-plutonium

“…This practice is based on the assumption that Pu and.Am are identically metabolized within a biological system. However, recent evidence have shown that this assumption is erroneous as soon as translocation begins (Johnson, 1969) and can present serious problems in the assessment of the quantity deposited internally. Because of its high toxicity and the difficulty of making in vivo measurements, nearly all biological knowledge of Pu has been gained through animal research.…”