Relatives of Crohn's disease patients and breast cancer: An overlooked condition

Abstract

Recent data suggest that patients suffering from Crohn's disease (CD) may be at higher risk of developing extra-intestinal malignancies. This is attributed to inflammation and immunodepression due to medications. However, a genetic predisposition cannot ruled out. In the present study we investigated the prevalence of breast cancer in first-degree female relatives of CD patients compared with relatives of patients without evidence of gastrointestinal diseases. A total of 1302 female first-degree relatives of CD patients and 1294 relatives of controls were included. We found that CD was an independent risk factor for breast cancer development (OR = 2.76, 95% CI = 1.2-6.2; p = 0.017), and this is particularly evident in mothers (3.6% vs 1%, p = 0.009 - OR = 3.7, 95% CI 1.4-10). Among CD group, smoking habit of CD patients was associated with increased risk of cancer compared with relatives of non-smokers (7.7% vs 2.9%, p = 0.01 - OR = 2.8 95% CI 1.2-6.6). Intriguingly, stage at diagnosis was significantly higher in CD relatives (p = 0.04). Our findings suggest that first-degree female relatives of CD patients are at higher risk of developing breast cancer but receive diagnosis at more advanced stages, therefore advocating the need of more active screening protocol in this population.

RETRACTED: Gallstone ileus without bilioenteric fistula years after bypass surgery for Crohn's disease. Case report and clues to etiology of a neglected cause of obstruction

“…Lastly, it increases the risk of malignancies in the long-term, especially in patients with long-standing CD. IBD are known risk factor for malignancies, via inflammation-driven pathways, different from those observed in sporadic cancerogenesis [17] , [18] , [19] . Thus, if the diseased segments are not removed, patients are exposed to unacceptably high risks of carcinoma.…”

Hormonal contraceptives and venous thromboembolism: Are inflammatory bowel disease patients at increased risk? A retrospective study on a prospective database

“…Etiopathogenesis of IBD relies on complex interactions between autoimmune mechanisms and environmental factors, which have not been fully understood [1] , [25] , [26] . IBD patients are at increased risk of cancer [13] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , which is a risk factor for VTE, so we sought for malignancies and excluded such patients from the analysis.…”

Az ösztrogénmetabolom biológiai és klinikai jelentősége lokális folyamatokban

“…A komplex főként a nukleáris mátrixra lokalizálódik, és ott részt vesz az ösztrogénre-ceptor mediálta malignus folyamatokban [52]. Pellino és mtsai kapcsolatot találtak az autoimmun kórképek és a malignus folyamatok kialakulása között: Crohn-betegségben szenvedő nőket és nőnemű rokonaikat vizsgálva pozitív korrelációt találtak az emlőkarcinóma kialakulá-sának esélyével [53]. Tian és mtsai nem mutattak ki meg- növekedett esélyt emlőkarcinóma kialakulására RA-s betegeknél [54].…”