Relaxant actions of PGE2 and its derivative (YPG-209) on canine tracheal smooth muscle and their enhancement of Ca++ uptake by the microsomal fraction.

Abstract

Abstract-The spasmogenic action of tetraethylammonium on canine tracheal smooth muscle was dependent on the extracellular Ca" concen tration.Acetylcholine, on the contrary, produced partial contraction for a certain period of time after removal of extracellular Ca", suggesting the release of Ca" from intracellular Ca" stores into the cytosol.PGE2, 16(S) methyl-20-methoxy-PGE2