Relaxation-based color magnetic particle imaging for viscosity mapping

Ütkür, Mustafa; Muslu, Yavuz; Sarıtaş, Emine Ülkü

doi:10.1063/1.5110475

Cited by 27 publications

(30 citation statements)

References 35 publications

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“…Since MPI has been validated in many stem cell therapy studies [ 33 , 34 , 35 , 36 , 37 ], we anticipate MPI’s advantages to be applicable to the adoptive cell therapy application as well. The main benefits of MPI in stem cells are innately transferable to the adoptive cell therapy application, such as (1) no loss in signal over time from magnetic cell labels enabling >90% of signal left over 89 days in vivo [ 33 ], (2) no radiation dose that will limit the length of a longitudinal study, (3) direct and quantitative measurement of magnetic label that is unaffected by changes in subject anatomy background over time [ 34 ], and (4) potential for assessment of viability of labeled cells via color MPI spectroscopic techniques demonstrated in various MPI studies that leverages microenvironment sensitivity for color/contrast change or for multi-contrast multiplexing [ 38 , 39 , 40 , 41 ]. These initial stem cell studies have demonstrated that the magnetic label remains internalized within the cell population of interest, and that any released label is rapidly cleared to the liver and does not confound the quantitation [ 33 ].…”

Section: Imaging Cancer Using Magnetic Particle Imagingmentioning

confidence: 99%

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Tay

Chandrasekharan

Fellows

et al. 2021

Cancers

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Background: Magnetic Particle Imaging (MPI) is an emerging imaging modality for quantitative direct imaging of superparamagnetic iron oxide nanoparticles (SPION or SPIO). With different physics from MRI, MPI benefits from ideal image contrast with zero background tissue signal. This enables clear visualization of cancer with image characteristics similar to PET or SPECT, but using radiation-free magnetic nanoparticles instead, with infinite-duration reporter persistence in vivo. MPI for cancer imaging: demonstrated months of quantitative imaging of the cancer-related immune response with in situ SPION-labelling of immune cells (e.g., neutrophils, CAR T-cells). Because MPI suffers absolutely no susceptibility artifacts in the lung, immuno-MPI could soon provide completely noninvasive early-stage diagnosis and treatment monitoring of lung cancers. MPI for magnetic steering: MPI gradients are ~150 × stronger than MRI, enabling remote magnetic steering of magneto-aerosol, nanoparticles, and catheter tips, enhancing therapeutic delivery by magnetic means. MPI for precision therapy: gradients enable focusing of magnetic hyperthermia and magnetic-actuated drug release with up to 2 mm precision. The extent of drug release from the magnetic nanocarrier can be quantitatively monitored by MPI of SPION’s MPS spectral changes within the nanocarrier. Conclusion: MPI is a promising new magnetic modality spanning cancer imaging to guided-therapy.

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Section: Imaging Cancer Using Magnetic Particle Imagingmentioning

confidence: 99%

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Tay

Chandrasekharan

Fellows

et al. 2021

Cancers

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“…A new area of research has been focused on discerning multiple sources of iron based on core size, or viscosity and temperature of the medium ( 67 , 68 ), owing to differences in Brownian relaxation rates. It has been shown that 2 different SPIONs can be discerned in the same image ( 69 ), and this has promising implications to track and distinguish multiple cell types in cell tracking experiments ( 62 ).…”

Section: Future Opportunitiesmentioning

confidence: 99%

A Perspective on Cell Tracking with Magnetic Particle Imaging

et al. 2020

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Many labs have been developing cellular magnetic resonance imaging (MRI), using both superparamagnetic iron oxide nanoparticles (SPIONs) and fluorine-19 ( 19 F)-based cell labels, to track immune and stem cells used for cellular therapies. Although SPION-based MRI cell tracking has very high sensitivity for cell detection, SPIONs are indirectly detected owing to relaxation effects on protons, producing negative magnetic resonance contrast with low signal specificity. Therefore, it is not possible to reliably quantify the local tissue concentration of SPION particles, and cell number cannot be determined. 19 F-based cell tracking has high specificity for perfluorocarbon-labeled cells, and 19 F signal is directly related to cell number. However, 19 F MRI has low sensitivity. Magnetic particle imaging (MPI) is a new imaging modality that directly detects SPIONs. SPION-based cell tracking using MPI displays great potential for overcoming the challenges of MRI-based cell tracking, allowing for both high cellular sensitivity and specificity, and quantification of SPION-labeled cell number. Here we describe nanoparticle and MPI system factors that influence MPI sensitivity and resolution, quantification methods, and give our perspective on testing and applying MPI for cell tracking.

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“…Ultimately this background signal may obscure detection of cells, especially in low cell numbers 24 , as it is challenging (at this time, impossible) to distinguish the signal associated with cells from background. Second, there is some evidence that Brownian relaxation of SPION in different tissue environments may be altered, leading to reduced MPI sensitivity [25][26][27] . Brownian motion refers to the physical rotation of SPIONs; this motion is reduced in tissues with increased stiffness (e.g.…”

Section: Discussionmentioning

confidence: 99%

The sensitivity of magnetic particle imaging and fluorine-19 magnetic resonance imaging for cell tracking

Sehl

Foster

2021

Preprint

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Purpose: Magnetic particle imaging (MPI) and fluorine-19 (19F) MRI produce images which allow for quantification of labeled cells. MPI is an emerging instrument for cell tracking, which is expected to have superior sensitivity compared to 19F MRI. Our objective is to assess the cellular sensitivity of MPI and 19F MRI for detection of mesenchymal stem cells (MSC) and breast cancer cells. Methods: Cells were labeled with ferucarbotran or perfluoropolyether, for imaging on a preclinical MPI system or 3 Tesla clinical MRI, respectively. In vivo sensitivity with MPI and 19F MRI was evaluated by imaging MSC that were administered by different routes. Results: Using the same imaging time, as few as 4000 MSC (76 ng iron) and 8000 breast cancer cells (74 ng iron) were reliably detected with MPI, and 256,000 MSC (9.01 x 10^16 19F atoms) were detected with 19F MRI, with SNR > 5. In vivo imaging revealed reduced sensitivity compared to ex vivo cell pellets of the same cell number. Conclusion: MPI has the potential to be more sensitive than 19F MRI for cell tracking. We attribute reduced MPI and 19F MRI cell detection in vivo to the effect of cell dispersion among other factors, which are described.

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Relaxation-based color magnetic particle imaging for viscosity mapping

Cited by 27 publications

References 35 publications

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

A Perspective on Cell Tracking with Magnetic Particle Imaging

The sensitivity of magnetic particle imaging and fluorine-19 magnetic resonance imaging for cell tracking

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