Release of a kinin by intraperitoneal injection of chemical agents in mice

Whittle, B. A.

doi:10.1016/0028-3908(64)90066-8

Cited by 40 publications

(17 citation statements)

References 5 publications

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“…It was previously reported that tolerance was induced in animals by repeated ad minitrastion of phenylquinone, acetic acid and all other agents tested except bradykinin (11)(12)(13). Thus in our experiments, the cumulative number of writhes in 15 minutes, induced by a single injection of phenylquinone was 47.0, while after a second dose 30 minutes after the first, the number was reduced to 11.6 as shown in Table I.…”

Section: Resultssupporting

confidence: 64%

“…Recently, it has been reported that various biologically active substances including amines (5,15), kinins (11), oxytocin (16,17) and ATP (18) also induce the writhing syndrome. However, the mechanisms of action of these agents are unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Whittle (11) reported that bradykinin was involved in the induction of writhing and further that writhing was related to an increase in cap illary permeability and release of bradykinin into the peritoneal cavity. On the other hand, Whittle (20) reported that non-narcotic analgesics inhibited both writhing and the increase in capillary permeability, whereas, narcotic analgesics and non-analgesics that inhibited writhing did not inhibit the increase in capillary permeability.…”

Section: Discussionmentioning

confidence: 99%

“…(12) reported cross-tolerance between phenylquinone and acetic acid. Bradykinin was reported to produce an episode of intense writhing, beginning immedi ately after injection of a second dose and has been cited as the only substance that is ac tive on repeated administration (11). It is noteworthy that a second dose of Diazo-ICA elicited as much writhing as a first dose and that writhing started immediately after its injection into mice which had developed tolerance to phenylquinone ( Table 1).…”

Section: Discussionmentioning

confidence: 99%

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Biological Activities of Diazonium Compounds: Induction of Hypothermia or Writhing by 4 (Or 5)-Diazoimidazole-5 (Or 4)-Carboxamide and Their Antagonism by Analgesics

Iwata

Dohi

Yamamoto

1970

Japanese Journal of Pharmacology

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Siegmund et al. (1), Hendershot and Forsaith (2) and Vander Wende and Margolin (3) first described a syndrome, commonly referred to as "writhing", which was induced in rodents by the intraperitoneal injection of various chemical agents.Collier et al. (4) have recently reported experiments on the abilities of various sub stances, including some occurring in tissues and causing pain in man, to induce abdominal construction in mice.Many investigators have described the non-specificity of the writhing syndrome, this phenomenon being blocked or antagonized by non-narcotic, and narcotic antago nists as well as narcotic analgesics. The inhibition of drug-induced writhing in mice has been proposed as a screening test for analgesics (1, 2, 5-7), although non-analgesic drugs also inhibit writhing (2,8,9).In the present experiments, intraperitoneal injection of the diazonium compound, 4 (or 5)-diazoimidazole-5 (or 4)-carboxamide had a profound effect on body temper ature and induced the writhing syndrome. Both the severe hypothermia and writhing following its inejction could be ameliorated with analgesics.The mechanism on these effect are discussed. MATERIALS AND METHODSFor experiments on body temperature, adult male Sprague-Dawley rats weighing 150-230 g were used and kept in separate cages. The animals were kept in a thermosta tically controlled room at 22±10C for at least 24 hours before experiments. Diets were removed 12 hours before experiments and water was removed during experiments. Ani mals with a mean temperature of less 37.5°C were not used. The rectal temperature was measured at 30 or 60 minute intervals with a probe thermometer inserted 4 cm into the rectum and as a rule data are represented as the mean temperature of 7 to 10 animals.Analgesics were injected subcutaneously into rats 30 minutes before, or at the same time as Diazo-ICA or related compounds. For the writhing test, male ddO strain mice,

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Section: Resultssupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Biological Activities of Diazonium Compounds: Induction of Hypothermia or Writhing by 4 (Or 5)-Diazoimidazole-5 (Or 4)-Carboxamide and Their Antagonism by Analgesics

Iwata

Dohi

Yamamoto

1970

Japanese Journal of Pharmacology

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“…O modelo químico de nocicepção de contorções abdominais em camundongos baseia-se na contagem das contorções da parede abdominal seguidas de torção do tronco e extensão dos membros posteriores (writhing), como resposta reflexa à irritação peritoneal e à peritonite produzidas pela injeção intraperitoneal de ácido acético. (Whittle, 1964).…”

Section: Discussionunclassified

Atividade analgésica do extrato da Pectis jangadensis (S. Moore)

Soares¹,

Marques²,

Rigolin³

et al. 2009

Rev. bras. farmacogn.

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RESUMO:A planta Pectis jangadensis, popularmente conhecida como "roxinha", "erva do carregador" ou "coentro da chapada" é utilizada em chás pela população matogrossense, como calmante. Não há estudo na literatura sobre qualquer atividade farmacológica dessa planta. Nosso objetivo foi avaliar atividade analgésica de seu extrato hidro-alcoólico nas doses de 100, 500 e 1000 mg/kg pelos métodos de Contorções induzidas pelo ácido acético e teste da formalina. Os nossos resultados demonstram que não houve diferença significativa entre o grupo controle e os grupos tratados com diferentes doses do extrato tanto em relação ao número de contorções induzidas pelo ácido acético quanto ao tempo de lambedura da pata, na fase 1 e 2, induzida pela formalina. Portanto, pelo menos, por via oral, parece que o extrato hidro-alcoólico da Pectis jangadensis não apresenta atividade analgésica. Unitermos:Pectis jangadensis, Asteraceae, atividade analgésica, "roxinha". ABSTRACT: "Preliminary evaluation of Pectis jangadensis (S. Moore) analgesic activity's".The plant Pectis jangadensis, popularly known as "roxinha", "erva do carregador" or "coentro da chapada" is used in teas by the matogrossense's people, as a calmative. There isn't any study in the literature about its pharmacologic activity. Our object was to evaluate its extract hidroalcoolic analgesic activity in doses of 100, 500 and 1000 mg/kg by the methods of abdominal writhing induced by acetic acid and the Formalin test. The results show that there wasn't significant difference between the control groups and the groups treated with different doses of the extract in both testes. Therefore, at least by oral, seems that the Pectis jangadensis' hidroalcoolic extract doesn't have analgesic activity.

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Antinociceptive Activity of an Ethanol Extract of Justicia spicigera

Zapata-Morales

Alonso-Castro

Domínguez³

et al. 2016

Drug Development Research

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Preclinical Research The aim of the present study was to evaluate the antinociceptive and sedative activity of an ethanol extract of Justicia spicigera an evergreen used in Mexican traditional medicine for the relief of pain, wounds, fever and inflammation. At 200 mg/kg po, the maximum dose examined, the ethanol extract of J. spicigera (JSE) had analgesic activity in mice in the acetic acid writhing test, the second phase of the formalin test and the tail flick test that was similar in efficacy to the NSAID, naproxen (150 mg/kg po). JSE was inactive in the hot plate test and and the ketamine-induced sleeping time test; it had no sedative effects. These results show that the ethanol extract from the leaves of J. spicigera has antinociceptive effects in mice without inducing sedation. Drug Dev Res 77 : 180-186, 2016. © 2016 Wiley Periodicals, Inc.

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Release of a kinin by intraperitoneal injection of chemical agents in mice

Cited by 40 publications

References 5 publications

Biological Activities of Diazonium Compounds: Induction of Hypothermia or Writhing by 4 (Or 5)-Diazoimidazole-5 (Or 4)-Carboxamide and Their Antagonism by Analgesics

Biological Activities of Diazonium Compounds: Induction of Hypothermia or Writhing by 4 (Or 5)-Diazoimidazole-5 (Or 4)-Carboxamide and Their Antagonism by Analgesics

Atividade analgésica do extrato da Pectis jangadensis (S. Moore)

Antinociceptive Activity of an Ethanol Extract of Justicia spicigera

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