Release of Bradykinin and the Mechanism of Production of a “Thermic Edema (45°C)” in the Rat’s Paw

Silva, M. Rocha E; Antônio, Augusto Fidalgo-Neto

doi:10.1159/000134981

Cited by 59 publications

(2 citation statements)

References 8 publications

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“…Indications are that vasoactive compounds play a major role in heat induced increases in blood flow, particularly at high temperatures. Silva and Antonio (1960) reported that bradykinin, a potent vasoactive compound, was released in the paw of the rat upon heating at 43.5-45"C. It is conceivable that our observation in the present study of the initial increase and the subsequent decrease in blood flow in muscle resulted from an initial release and subsequent depletion of vasoactive compounds such as bradykinin and/or histamine (Shea et al 1973, Gabbiani andBadonnel 1975).…”

Section: Discussionmentioning

confidence: 53%

Changes in muscle blood flow distribution during hyperthermia

Akyurekli

Gerig

Raaphorst

1997

International Journal of Hyperthermia

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Blood flow is a critical parameter for obtaining satisfactory temperature distributions during clinical hyperthermia. This study examines the changes in blood flow distribution in normal porcine skeletal muscle before, during and after a period of regional microwave hyperthermia. The baseline blood flow distribution during general anaesthesia and after the insertion of the thermal probes was established independently in order to isolate the changes due to hyperthermia. General anaesthesia alone and thermocouple insertion during anesthesia had no significant effect on the muscle blood flow distribution. Regional microwave heating generated a non-uniform blood flow distribution which was a function of the tissue temperature distribution. Blood flow was greater in those tissues samples in which higher temperatures were recorded and less in those sampled further from the applicators peak SAR (Specific Absorption Rate). The increase in blood flow appears to be primarily a local phenomenon. Although muscle blood flow may be considered to be uniform prior to heating, this does not hold during hyperthermia treatment. Therefore, the non-uniform nature of the blood distribution during heating should be incorporated into any practical bioheat transfer model.

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Section: Discussionmentioning

confidence: 53%

Changes in muscle blood flow distribution during hyperthermia

Akyurekli

Gerig

Raaphorst

1997

International Journal of Hyperthermia

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“…The release of bradykinin can also directly dilate blood vessels. As shown by Silva and Antonio [20], the steps responsible for these releases could also be activated by elevated temperatures. (2) Metabolically-induced localized hypoxia, acidosis or adenosine, K þ ions, phosphate ion release and hyperosmolarity can each separately induce increased local perfusion [7,19,21].…”

Section: Introductionmentioning

confidence: 85%

A thermo-pharmacokinetic model of tissue temperature oscillations during localized heating

Chen

Roemer

2005

International Journal of Hyperthermia

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Thermally-induced large blood flow increases and oscillations have been experimentally observed in both muscle and prostate tissues. However, the bio-physical/-chemical mechanisms underlying these phenomena remain undiscovered. To study the basic nature of these coupled thermal-mass transport processes, this study combines a compartmental vasodilator pharmacokinetics model with a bio-heat-transfer temperature model. The resulting simulated temperature responses to different applied power levels closely match both the overall behaviour and the fine structure of the complex temperature responses observed in vivo. This suggests that the coupled thermo-pharmacokinetic model captures the essence of the links between tissue temperature and blood flow oscillations and of the role of the important vaso-active substances. Thus, it appears that such thermo-pharmacokinetic models can provide a basis for helping to understand and quantify the fundamental bio-physical/-chemical processes that couple the transient tissue temperature distributions to blood flow oscillations. Such combined models allow investigators to directly predict tissue blood flow responses to applied power and avoid the need to make ad hoc assumptions regulating the blood flow rates present in heated tissues.

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