Release of endothelial microparticles in patients with arterial hypertension, hypertensive emergencies and catheter-related injury

Sansone, Roberto; Baaken, Maximilian; Horn, Patrick; Schuler, Dominik; Westenfeld, Ralf; Amabile, Nicolas; Kelm, Malte; Heiß, Christian

doi:10.1016/j.atherosclerosis.2018.04.012

Cited by 32 publications

(37 citation statements)

References 25 publications

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“…Interestingly, we also observed an inverse association between CD62E+ MPs and SBP. While this appears to contradict reports of elevated MPs in hypertensive individuals (Sansone et al, 2018), it is possible that medications used to control blood pressures in the CAD and NSTEMI groups attenuate MP release. This provides further support for the need to better understand the role of medications on MP concentrations.…”

Section: Cd62e+ Mpsmentioning

confidence: 58%

Circulating microparticle concentrations across acute and chronic cardiovascular disease conditions

et al. 2020

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Section: Cd62e+ Mpsmentioning

confidence: 58%

Circulating microparticle concentrations across acute and chronic cardiovascular disease conditions

et al. 2020

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“…Compared with the parental cells, cell derived microparticles can exert more potent effects on target organs as they can deliver highly concentrated biological messages including protein, DNA, mRNA and microRNA. In the case of acute injury, endothelial cells may respond by dislodgement-induced EMP generation and EMPs are capable of inducing a procoagulant and thrombotic state ( 31-33 ). Coagulant TF has been shown to be an important pathway in these events ( 34 , 35 ).…”

Section: Discussionmentioning

confidence: 99%

Role of endothelial‑microparticles and the tissue factor pathway in ginsenoside Rb1‑mediated prevention of umbilical vein endothelial cell injury

et al. 2020

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Hepatic veno-occlusive disease (VOD) is a life-threatening complication of hematopoietic stem cell transplantation, which urgently requires effective prevention and treatment. Endothelial damage is recognized as the first event in patients with hepatic VOD. However, the mechanism by which endothelial injury induces thrombosis in hepatic VOD is still not clear. In the present study, monocrotaline (MCT) was used to induce endothelial cell injury in EA.hy926 cells to imitate in vitro hepatic VOD. MCT significantly increased apoptosis in EA.hy926 endothelial cells and the secretion of endothelial microparticles (EMPs) which can be used to reflect the level of endothelial injury. Additionally, MCT significantly enhanced the expression of soluble tissue factor (TF) and EMP-bound TF protein, suggesting that EMPs may participate in the development of hepatic VOD by regulating coagulation. Ginsenoside Rb1, a major constituent and effective ingredient of Panax ginseng, was found to significantly decrease MCT-induced endothelial injury and release of EMPs. Moreover, Ginsenoside Rb1 decreased soluble TF released by EA.hy926 cells and EMP-bound TF protein induced by MCT. These data suggest that ginsenoside Rb1 may serve as a potent prophylactic and/or as a treatment of hepatic VOD by protecting endothelial cells and preventing microthrombosis induced by endothelial injury.

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“…Circulating microparticles, also called extracellular vesicles or shedding vesicles, are released from the endothelium, platelets, and many other cells and may have physiological or pathological effects (24). The diameters of circulating microparticles are usually in the range of 100-500 nm, and an elevated number of circulating microparticles has been reported in many pathological conditions and in subjects with uncontrolled hypertension (25), acute myocardial infarction (26), or chronic kidney disease (27).…”

Section: Discussionmentioning

confidence: 99%

Circulating microparticles and central blood pressure according to antihypertensive strategy

Massunaga

França

Bianco

et al. 2019

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OBJECTIVES:This prospective, randomized, open-label study aimed to compare the effects of antihypertensive treatment based on amlodipine or hydrochlorothiazide on the circulating microparticles and central blood pressure values of hypertensive patients.METHODS:The effects of treatments on circulating microparticles were assessed during monotherapy and after the consecutive addition of valsartan and rosuvastatin followed by the withdrawal of rosuvastatin. Each treatment period lasted for 30 days. Central blood pressure and pulse wave velocity were measured at the end of each period. Endothelial, monocyte, and platelet circulating microparticles were determined by flow cytometry. Central blood pressure values and pulse wave velocity were recorded at the end of each treatment period.RESULTS:No differences in brachial blood pressure were observed between the treatment groups throughout the study. Although similar central blood pressure values were observed during monotherapy, lower systolic and diastolic central blood pressure values and early and late blood pressure peaks were observed in the amlodipine arm after the addition of valsartan alone or combined with rosuvastatin. Hydrochlorothiazide-based therapy was associated with a lower number of endothelial microparticles throughout the study, whereas a higher number of platelet microparticles was observed after rosuvastatin withdrawal in the amlodipine arm.CONCLUSIONS:Despite similar brachial blood pressure values between groups throughout the study, exposure to amlodipine was associated with lower central blood pressure values after combination with valsartan, indicating a beneficial interaction. Differences between circulating microparticles were modest and were mainly influenced by rosuvastatin withdrawal in the amlodipine arm.

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Release of endothelial microparticles in patients with arterial hypertension, hypertensive emergencies and catheter-related injury

Cited by 32 publications

References 25 publications

Circulating microparticle concentrations across acute and chronic cardiovascular disease conditions

Circulating microparticle concentrations across acute and chronic cardiovascular disease conditions

Role of endothelial‑microparticles and the tissue factor pathway in ginsenoside Rb1‑mediated prevention of umbilical vein endothelial cell injury

Circulating microparticles and central blood pressure according to antihypertensive strategy

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