Release of gastric inhibitory polypeptide (GIP) during calcium infusion and in hyperparathyroidism

Toyota, Takayoshi; Nakanome, Chiyuki; Akai, Hiroaki; Umezu, Motoaki; Gotō, Yoshio

doi:10.1016/0167-0115(82)90104-5

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…This mechanism has not been explained to date, and it is not known whether Ca influences the secretion of gastrointestinal hormones or vice versa. Furthermore, Toyota et al ( 22 ) elucidated that hypercalcaemia might have stimulatory effects on glucose-induced GIP release. These two publications point to a direct effect of Ca on the secretion of gastrointestinal hormones.…”

Section: Discussionmentioning

confidence: 99%

Effect of supplementary calcium phosphate on plasma gastrointestinal hormones in a double-blind, placebo-controlled, cross-over human study

Trautvetter

Jahreis

2013

Br J Nutr

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Gastrointestinal hormones and Ca are associated with bone metabolism. The objective of the present human study was to determine the effect of calcium phosphate on the postprandial circulation of gastrointestinal hormones. A total of ten men participated in the present double-blind, placebo-controlled, cross-over study. The participants were divided into two groups. Of these, one group consumed bread enriched with 1 g Ca (pentacalcium hydroxy-triphosphate, CaP) daily for 3 weeks. The other group consumed placebo bread. After 2 weeks of washout, the intervention was changed between the groups for another 3 weeks. The subjects consumed a defined diet at the beginning (single administration) and at the end (repeated administration) of the intervention periods, and blood samples were drawn at 0, 30, 60, 120, 180 and 240 min. Between 0 and 30 min, the participants consumed a test meal, with or without CaP. The concentrations of gastrointestinal hormones (glucose-dependent insulinotropic polypeptide, glucagon-like peptide (GLP) 1 and GLP2), insulin and glucose were determined. The AUC of GLP1 (total and active) and GLP2 increased significantly after the repeated CaP administrations compared with that after placebo administration. The AUC of insulin and glucose showed no differences between the CaP and placebo administrations. CaP affects the postprandial plasma concentrations of gastrointestinal hormones through the modulation of the intestinal environment, e.g. bile acids and microbiota.

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Section: Discussionmentioning

confidence: 99%

Effect of supplementary calcium phosphate on plasma gastrointestinal hormones in a double-blind, placebo-controlled, cross-over human study

Trautvetter

Jahreis

2013

Br J Nutr

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“…23,24 On that basis, there is only one published study examining the effect of Ca infusion and hyperparathyroidism on GIP secretion, which reported that glucose-stimulated GIP secretion in individuals with hypercalcemia (serum Ca above 11 mg/dL) was higher than individuals with normal Ca levels, as well as in patients with hyperparathyroidism compared with healthy individuals. 48 A positive correlation of PTH with fGLP-1 was evident. Both molecules act at receptors belonging to the small family of B1 G proteinecoupled receptors (secretin-like receptors), 49 which have been identified in islet cells, osteoblasts, and adipocytes.…”

Section: Discussionmentioning

confidence: 89%

“…54 Overall, a possible association between PTH normalization and insulin secretion, either through enhancement of GSIS secretion and GLP-1 action or indirectly through the improvement of IR after PTX would require further mechanistic studies to establish a "causeeeffect" relationship. 48 A relative strength of our study is that it included euglycemic individuals, providing physiological experimental conditions, that would not be feasible in glucose-intolerant Table 6 e AUC of OGTT response of glucose (mg/dL/ 120 min), insulin (mIU/mL/120 min), GLP-1 (pg/mL/ 120 min), and GIP (pg/mL/120 min) before and after parathyroidectomy (PTX). patients.…”

Section: Discussionmentioning

confidence: 99%

Rising Glucagon-Like Peptide 1 Concentrations After Parathyroidectomy in Patients With Primary Hyperparathyroidism

Antonopoulou

Karras

Koufakis

et al. 2020

Journal of Surgical Research

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“…Plasma hormone levels were assayed by specific radioimmunoassays for PP (Toyota et al 1980), glucagon (Toyota et al 1982), insulin (Toyota et al 1982), gastrin (Nakanome et al 1981), and growth hormone (Hanew et al 1980). Hormone content of the tumor was also analysed by radioimmunoassay for somatostatin (Yanaihara et al 1978), PP, vasoactive intestinal polypeptide (VIP, Yanaihara et al 1977), glucagon, /3-MSH, ACTH (Abe et al 1979), and gastrin.…”

Section: Methodsmentioning

confidence: 99%

Somatostatinoma syndrome accompanied by overproduction of pancreatic polypeptide.

Nakanome

Koizumi

Fujiya

et al. 1984

Tohoku J. Exp. Med.

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A case of somatostatin and pancreatic polypeptide (PP) producing tumor of the pancreas is presented. A 65-year-old woman was admitted for the evaluation of the tumor in the right upper quadrant of the abdomen. Clinical abnormalities included diabetic glucose intolerance, pancreatic insufficiency and marked dilatation of gallbladder. Marked high concentration of plasma PP and low levels of plasma insulin and glucagon were observed before operation. Plasma insulin concentrations in response to oral glucose tolerance test and arginine infusion were markedly low. A large quantity of somatostatin (4,300 ng/g ww) as well as PP (1,340 ng/g ww) was detected in the tumor, and somatostatin cells and PP cells were determined by immunofluorescence studies. After operation, pancreatic insufficiency and glucose intolerance were improved, and the patient made a favorable progress. somatostatinoma syndrome ; pancreatic polypeptide ; pancreatic endocrine tumor

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Release of gastric inhibitory polypeptide (GIP) during calcium infusion and in hyperparathyroidism

Cited by 5 publications

References 20 publications

Effect of supplementary calcium phosphate on plasma gastrointestinal hormones in a double-blind, placebo-controlled, cross-over human study

Effect of supplementary calcium phosphate on plasma gastrointestinal hormones in a double-blind, placebo-controlled, cross-over human study

Rising Glucagon-Like Peptide 1 Concentrations After Parathyroidectomy in Patients With Primary Hyperparathyroidism

Somatostatinoma syndrome accompanied by overproduction of pancreatic polypeptide.

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