Release of immunoreactive substance P (SP) and vasointestinal peptide (VIP) form guinea-pig upper airways by platelet-activating factor (PAF-ACETHER)

Rodrigue, F.; Hoff, Per Ivar; Touvay, Caroline; Carré, C; Vilain, B.; Mencia‐Huerta, Jean Michel; Braquet, P.

doi:10.1016/0090-6980(87)90221-8

Cited by 4 publications

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“…Recently some evidence has been presented which suggests a possible interaction between these two classes of biological mediators. PAF has been shown to release VIP and substance P from guinea-pig isolated lung strip (Rodrigue et al, 1987). In addition, some of the motor effects of leukotriene D4 may involve the release of sensory neurotransmitters (Stewart et al, 1984;Bloomquist & Kream, 1987).…”

Section: Introductionmentioning

confidence: 99%

Involvement of capsaicin‐sensitive nerves in the bronchomotor effects of arachidonic acid and melittin: a possible role for lipoxin A₄

Manzini

Meini

1991

British J Pharmacology

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1 Functional studies have been performed to evaluate the potential involvement of capsaicin-sensitive nerves in the bronchomotor responses evoked by lipid mediators produced from the metabolic breakdown of arachidonic acid (AA) in the guinea-pig bronchus. 2 In the presence of indomethacin, the exogenous administration of AA (0.01-1 mM) produced a concentration-dependent contractile response in guinea-pig isolated bronchial rings. AA-induced contractions were augmented by epithelium-removal and by thiorphan (10pM), an inhibitor of tachykinin breakdown. A sustained downward and rightward displacement of the complete concentration-response curve to AA was observed after in vitro capsaicin desensitization. 3 BWA4C (1 pM), a selective inhibitor of 5-lipoxygenase, shifted the AA concentration-response curve to the right. In the presence of this inhibitor, capsaicin desensitization did not have any further inhibitory action. 4 A potent, concentration-dependent and capsaicin-sensitive bronchoconstrictor effect was also observed with the polypeptide, melittin (10nM-lipM), an activator of phospholipase A2, which therefore should generate endogenous AA. 5In vitro capsaicin-desensitization produced a significant reduction of the bronchomotor responses evoked by lipoxin A4 (1-6,UM), but not of those elicited by other lipoxygenases products such as leukotriene D4 (1-lOOnM) or by 15-hydroxyeicosatetraenoic acid (15-HETE, 1-6pM). 6 These findings indicate that lipoxin A4 but not leukotriene D4 or 15-HETE, might be one of the lipoxygenase mediators of excitatory effects of AA on capsaicin-sensitive sensory nerves.

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Section: Introductionmentioning

confidence: 99%

Involvement of capsaicin‐sensitive nerves in the bronchomotor effects of arachidonic acid and melittin: a possible role for lipoxin A₄

Manzini

Meini

1991

British J Pharmacology

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PAF and Antigen-Induced Bronchial Hyperreactivity in Guinea Pigs

Milne

Rossi

Chapman

1996

Airways Smooth Muscle: Modelling the Asthmatic Response in Vivo

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Pharmacologic and Neurochemical Evidence for the Activation of Capsaicin-sensitive Sensory Nerves by Lipoxin A₄in Guinea Pig Bronchus

Meini

Evangelista²,

Geppetti³

et al. 1992

Am Rev Respir Dis

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Exogenous administration of lipoxin A4 (LXA4) to guinea pig isolated bronchus produced contractile effects in a concentration-dependent manner (1, 3, and 6 microM). These responses were potentiated when preparations were previously incubated with thiorphan (10 microM), an inhibitor of tachykinin breakdown, but were significantly depressed when sensory nerves were previously desensitized in vitro by capsaicin (10 microM for 15 min) challenge. Ruthenium red (10 microM for 20 min), a blocker of the cationic channel coupled to the capsaicin receptor, also produced, although in a weaker manner, a reduction in bronchomotor responses elicited by LXA4. On the other hand, preexposure to omega-conotoxin (0.1 microM for 45 min), a blocker of neuronal voltage-dependent Ca2+ channels, did not modify the LXA4 contractile effects. Furthermore, LXA4 (6 microM) superfusion of guinea pig bronchial tissue elicited a significant calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) release that was reduced by capsaicin (10 microM, 30 min) desensitization. Finally, LXA4 (10 microM) was unable to displace [3H]resiniferatoxin binding in dorsal root ganglion of rat and guinea pig. These findings support (1) a role for LXA4 in activating motor sensory function of capsaicin-sensitive nerves; (2) this activation mechanism is marginally ruthenium red-sensitive and omega-conotoxin-resistant; and (3) the interaction does not involve the recognized binding site on the vanilloid receptor. As a whole this study presents LXA4 as an endogenous mediator activating sensory nerves potentially involved in basic mechanisms of airway diseases.

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Release of immunoreactive substance P (SP) and vasointestinal peptide (VIP) form guinea-pig upper airways by platelet-activating factor (PAF-ACETHER)

Cited by 4 publications

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Involvement of capsaicin‐sensitive nerves in the bronchomotor effects of arachidonic acid and melittin: a possible role for lipoxin A₄

Involvement of capsaicin‐sensitive nerves in the bronchomotor effects of arachidonic acid and melittin: a possible role for lipoxin A₄

PAF and Antigen-Induced Bronchial Hyperreactivity in Guinea Pigs

Pharmacologic and Neurochemical Evidence for the Activation of Capsaicin-sensitive Sensory Nerves by Lipoxin A₄in Guinea Pig Bronchus

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Release of immunoreactive substance P (SP) and vasointestinal peptide (VIP) form guinea-pig upper airways by platelet-activating factor (PAF-ACETHER)

Cited by 4 publications

References 0 publications

Involvement of capsaicin‐sensitive nerves in the bronchomotor effects of arachidonic acid and melittin: a possible role for lipoxin A4

Involvement of capsaicin‐sensitive nerves in the bronchomotor effects of arachidonic acid and melittin: a possible role for lipoxin A4

PAF and Antigen-Induced Bronchial Hyperreactivity in Guinea Pigs

Pharmacologic and Neurochemical Evidence for the Activation of Capsaicin-sensitive Sensory Nerves by Lipoxin A4in Guinea Pig Bronchus

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Involvement of capsaicin‐sensitive nerves in the bronchomotor effects of arachidonic acid and melittin: a possible role for lipoxin A₄

Involvement of capsaicin‐sensitive nerves in the bronchomotor effects of arachidonic acid and melittin: a possible role for lipoxin A₄

Pharmacologic and Neurochemical Evidence for the Activation of Capsaicin-sensitive Sensory Nerves by Lipoxin A₄in Guinea Pig Bronchus