Relevance of cortical thickness in migraine sufferers

Hadjikhani, Nouchine

doi:10.1586/14737175.8.3.327

Cited by 19 publications

(24 citation statements)

References 33 publications

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“…This is particularly interesting, as these areas have previously been described as a source of spreading changes involved in the visual aura [54]. It seems that a structural abnormality in the network of motion-processing areas could account for, or be the result of, the cortical hyperexcitability that is observed in migraineurs [55]. It seems that a structural abnormality in the network of motion-processing areas could account for, or be the result of, the cortical hyperexcitability that is observed in migraineurs [55].…”

Section: Cortical Thickness Analysismentioning

confidence: 88%

Microstructural and network abnormalities in headache

Ellerbrock¹,

Engel

May³

2013

Current Opinion in Neurology

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Owing to novel neuroimaging approaches and evaluation methods, a range of possibilities for exploring brain differences between migraine patients and healthy subjects have become available. These include both regional structural alterations and network connectivity changes. Despite methodological advances, most studies involve still small populations and results are often inconclusive. Future work should clearly involve larger cohorts and combine different techniques to help us better understand the diagnostic implications.

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Section: Cortical Thickness Analysismentioning

confidence: 88%

Microstructural and network abnormalities in headache

Ellerbrock¹,

Engel

May³

2013

Current Opinion in Neurology

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“…Using another technique to investigate grey matter abnormalities, DaSilva and colleagues studied the cortical thickness and found thickening of the somatosensory cortex in migraineurs relative to healthy controls [55]. This may be due to increased afferent activity within the somatosensory system in migraine patients [56]. More recently, reports of decreased gray matter volume in episodic migraine (vs. control) in the following cortical regions were published: Superior temporal gyrus, inferior frontal gyrus, and precentralgyrus [57].…”

Section: Imaging Changes Of Brain Structure – Migraine-related Gramentioning

confidence: 99%

Migraine changes the brain

Sprenger

Borsook

2012

Current Opinion in Neurology

110

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Purpose of review To summarize key findings of the current literature on functional neuroimaging in migraine and to describe how these studies have changed our view of the disorder. Recent findings: Recent studies have started to investigate not only the global cerebral activation pattern during migraine attacks, but to address specific aspects of migraine attacks such as photophobia, osmophobia as well as pain perception with the aim of disentangling the underlying mechanisms. There is also more and more evidence that the migraine brain is abnormal even outside of attacks and that repeated attacks are leading to functional and structural alterations in the brain, which may in turn drive the transformation of migraine to its chronic form. Some new results are pinpointing towards a potential role of interesting new brain areas in migraine pathophysiology such as the temporal cortex or the basal ganglia. Summary Neuroimaging studies are beginning to shed light on the mechanisms underlying the development and evolution of migraine and its specific symptoms. Future studies have the potential to also improve our understanding of established and upcoming treatment approaches and to monitor treatment effects in an objective and non-invasive way.

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“…Our results have implications for identifying potential cortical substrates for disease progression and chronicity in migraine. Cortical thickness changes in migraine could possibly indicate focal dysplasias, reactive gliosis, and activity‐dependent plasticity secondary to repetitive migraine attacks . Based on mutual trophism or Hebbian plasticity principles, cortical thickness covariance in CM may represent atypical or compensatory cortico‐cortical connections across multiple regions occurring simultaneously.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features Contributing to Cortical Thickness Changes in Chronic Migraine – A Pilot Study

et al. 2018

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Objectives.-The objectives of this cross-sectional pilot study were threefold: to identify regions of cortical thickness that differentiate chronic migraine (CM) from controls, to assess group differences in interregional cortical thickness covariance, and to determine group differences in associations between clinical variables and cortical thickness.Background.-Cortical thickness alterations in relation to clinical features have not been adequately explored in CM. Assessment of this relationship can be useful to describe cortical substrates for disease progression in migraine and to identify clinical variables that warrant management emphasis.Methods.-Thirty CM cases (mean age 40 years; male-to-female 1:4) and 30 sex-matched healthy controls (mean age 40 years) were enrolled. Participants completed self-administered and standardized questionnaires assessing headache-related clinical features and common psychological comorbidities. T1-weighted brain images were acquired on a 3T MRI. A whole-brain cortical thickness analysis was performed. Additionally, correlations between all brain regions were assessed to examine interregional cortical thickness covariance. Interactions were analyzed to identify clinical variables that were significantly associated with cortical thickness.Results.-The whole brain cortical thickness analysis revealed no significant differences between CM patients and controls. However, significant associations between clinical features and cortical thickness were observed for the patients only. These associations included the right superior temporal sulcus (R 2 = 0.72, P = .001) and the right insula (R 2 = 0.71, P = .002) with distinct clinical variables ie, longer history of CM, posttraumatic stress disorder (PTSD), sleep quality, pain self-efficacy, and somatic symptoms. Higher interregional cortical covariance was found in CM compared to controls (OR = 3.1, CI 2.10-4.56, P < .0001), such that cortical thickness between regions tended to be more correlated in patients, particularly in the temporal and frontal lobes.Conclusion.-CM patients have significantly greater cortical covariance compared to controls. Cortical thickness in CM patients was predominantly accounted for by CM duration, PTSD, and poor sleep quality, while improved pain self-efficacy buffered cortical thickness. While it is important to address all CM features and comorbidities, it may be useful to emphasize optimizing the management of certain clinical features that contribute to cortical abnormalities including managing PTSD, early management to shorten duration of CM, and improving pain self-efficacy and sleep quality. Abbreviations: CM chronic migraine, CSF cerebrospinal fluid, EM episodic migraine, GAD-7 generalized anxiety disorder-7, GM gray matter, ICHD International Classification of Headache Disorders, IQR interquartile range, MIDAS migraine disability assessment, MOH medication overuse headache, PC-PTSD primary care posttraumatic stress disorder, PCS pain catastrophizing scale, PHQ-9 patient health questionnaire-9, ...

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Relevance of cortical thickness in migraine sufferers

Cited by 19 publications

References 33 publications

Microstructural and network abnormalities in headache

Microstructural and network abnormalities in headache

Migraine changes the brain

Clinical Features Contributing to Cortical Thickness Changes in Chronic Migraine – A Pilot Study

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