Relevance of erythrocyte sedimentation rate and C-reactive protein in patients with active uveitis

Groen-Hakan, Fahriye; Eurelings, Laura; Laar, Jan van; Rothová, Aniki

doi:10.1007/s00417-018-4174-7

Cited by 13 publications

(5 citation statements)

References 27 publications

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“…The most common investigations done were CBC, CXR, Mantoux test (77.6%), and ESR. CBC, ESR and C-reactive protein (CRP) were found to be within the normal limit in the majority of uveitis patients and were not related to any specific cause of uveitis in an earlier study [9] . CXR was abnormal in only 15% of active uveitis cases in a cross-control study reported by Groen et al [10] .…”

Section: Discussionmentioning

confidence: 80%

First contact investigations and compliance to treatment in patients with uveitis

Patil,

Venkatesh,

Banerjee

et al. 2023

Int J Ophthalmol

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AIM: To ascertain the pattern of investigations at first contact in uveitic patients and evaluate compliance to treatment. METHODS: An observational study comprised of 201 uveitic patients presenting for the first time to our centre from January 2019 to June 2020. Detailed information regarding systemic investigations undertaken by specialists at the time of first contact and the cost of these investigations were reviewed on the first visit to our centre. Compliance with the treatment was determined and reasons behind non-compliance were evaluated on the first follow-up in patients who had no improvement in clinical signs and symptoms. RESULTS: The mean age of the study group was 35.35±14.1y and gender composition was 59.7% males and 40.3% females. Anterior uveitis was observed in 45.3% of patients, intermediate uveitis in 31.8% of patients, posterior uveitis in 14.9% of patients and panuveitis in 8.0% of patients. Association with a systemic disease was evident in 17.9% of patients. When compared with standard guidelines and uveitis patterns, systemic investigations were identified to be relevant only in 38.3% of patients. Non-compliance to treatment was documented in 22.4% of patients. Common reasons for non-compliance were inadequate counselling by the treating physician about treatment in 26.7% of patients and a busy schedule at work/school in 22.2% of patients. CONCLUSION: Significant number of investigations performed at first contact is found to be contrary to standard guidelines and are not contributory to the care. About a quarter of patients in this study are found to be non-compliant with the treatment. Compliance is more challenging to achieve in school-going children and working adults. The availability of comprehensive, periodically updated, evidence-based guidelines on the role of investigations and the use of trained counsellors may help to channelize proper evaluation and improve compliance to treatment, respectively, in patients with uveitis.

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Section: Discussionmentioning

confidence: 80%

First contact investigations and compliance to treatment in patients with uveitis

Patil,

Venkatesh,

Banerjee

et al. 2023

Int J Ophthalmol

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“…CRP can have various values in sinusitis, and increased values can aid in its early diagnosis [ 996 , 997 ]. Moreover, CRP concentrations can vary from relatively normal to notably elevated values in uveitis cases [ 998 ]. An old study has shown various serum CRP levels in acute otitis media cases, but high values (>20 mg/L) were observed in those with bacterial infection [ 999 ].…”

Section: Current Evidence On C-reactive Protein and Potential Conditionsmentioning

confidence: 99%

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Mouliou

2023

Diseases

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The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of various diseases is presented, of all cardiovascular, respiratory, hepatobiliary, gastrointestinal, pancreatic, renal, gynecological, andrological, dental, oral, otorhinolaryngological, ophthalmological, dermatological, musculoskeletal, neurological, mental, splenic, thyroid conditions, as well as infections, autoimmune-supposed conditions and neoplasms, including other possible factors that have been linked with elevated concentrations of that protein. Moreover, data on molecular diagnostics on CRP are discussed, and possible etiologies of false test results are highlighted. Additionally, this review evaluates all current pieces of evidence on CRP and systemic inflammation, and highlights future goals. Finally, a novel diagnostic algorithm to carefully assess the CRP level for a precise diagnosis of a medical condition is illustrated.

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“…The proteins S100A8 [myeloid-related protein 8) and S100A9 [myeloid-related protein 14) combine to make calprotectin, which is primarily produced by activated granulocytes and monocytes in the blood and in amed tissues [5]. As it binds toll-like receptor 4 (TLR4)-like damage-associated molecular patterns (DAMPs), it is regarded as an endogenous activator of innate immune response, boosting the release of proin ammatory cytokines, [6].…”

Section: Introductionmentioning

confidence: 99%

Calprotectin as a non-invasive biomarker for Acute Noninfectious Granulomatous Anterior Uveitis in Egyptian Patients

Nage

Esmail

2022

Preprint

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Purpose To study the relation between serum calprotectin level and acute noninfectious anterior uveitis in Egyptian patients. Methods An observational prospective study carried out at Menoufia University Hospital during the period from march 2021 till June 2022, after informed consent from all studied patients. This study included 20 eyes of patients with Acute Anterior Uveitis (AAU) and 20 eyes healthy individuals matched sex and age as the control group. Full history taking, ophthalmological examination and serum calprotectin levels were performed for both patients and controls. Results The majority of AAU patients' eyes (55%) had a moderate grade, followed by a faint grade (30%) and a pronounced grade (15%). Serum calprotectin levels were substantially higher in patients with acute anterior uveitis than in healthy eyes (61.45 ± 7.89 vs. 32.50 ± 11.64; 95% CI: 22.58–35.32; P < 0.001). In comparison to negative previous uveitis and mild to moderate anterior uveitis, serum calprotectin levels were substantially higher with positive previous uveitis (64.75 ± 4.65) and notable grade (67.00 ± 2.65). The serum calprotectin cutoff point for diagnosing AAU was 58.0, with sensitivity of 95% and specificity of 43%. Serum calprotectin had a cutoff value in the prognosis of AAU of 63.0, with a sensitivity of 91.7% and a specificity of 37.5%. Conclusion Serum calprotectin levels was significantly higher with positive previous uveitis and marked grade indicating a possible role of calprotectin in the pathogenesis of noninfectious AAU. Finally, we discovered serum calprotectin as a possible biomarker for predicting patients' mortality risk and the likelihood of developing anterior uveitis, whose prompt monitoring may enhance the prognosis of anterior uveitis.

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Relevance of erythrocyte sedimentation rate and C-reactive protein in patients with active uveitis

Cited by 13 publications

References 27 publications

First contact investigations and compliance to treatment in patients with uveitis

First contact investigations and compliance to treatment in patients with uveitis

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Calprotectin as a non-invasive biomarker for Acute Noninfectious Granulomatous Anterior Uveitis in Egyptian Patients

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