Relieving effect of Artemisia argyi aqueous extract on immune stress in broilers

Abstract

This experiment aimed to investigate the relieving action of Artemisia argyi aqueous extract (AAE) on immune stress in broiler chickens. A 2 × 2 factorial design was used to test the effect of 2 dietary treatments (adding 0 or 1000 mg/kg AAE) and 2 immune stress treatments (injecting saline or lipopolysaccharide (LPS)). A total of 96 one-day-old Arbor Acres (AA) broilers were randomly divided into four treatment groups with six replicates, four birds in each replicate. Broilers in Treatment groups 1 and 2 were fed with the basal diet, and those in Treatment groups 3 and 4 were fed with the experimental diet supplemented with 1000 mg/kg AAE. On days 14, 16, 18 and 20, broilers in both Treatments 1 and 3 were injected intra-abdominally with LPS solution at the dose of 500 μg LPS per kg BW with the LPS dissolved in sterile saline at a concentration of 100 μg/ml, and those in Treatments 2 and 4 were injected intra-abdominally with equal amount of sterile 0.9% saline. Blood samples were collected on days 21 and 28. The results showed that dietary supplementation of AAE prevented reductions in average daily gain (ADG) and average daily feed intake (ADFI) of broilers caused by LPS on d 15-21. On day 21, the injection of LPS increased serum adrenocorticotropic hormone (ACTH) and corticosterone (CORT); meanwhile, feeding AAE reduced the rise of CORT caused by LPS. Immune parameters such as interleukin-1 (IL-1), interleukin-2 (IL-2), interleukin-6 (IL-6), immunoglobulin G (IgG) and immunoglobulin A (IgA) were also improved by LPS, but the content of IL-2 and IgG in broilers fed with AAE diet was significantly lower than that of broilers fed with control diet. All the data suggested that diets supplemented with AAE could relieve the immune stress response of broilers.

Dietary L-theanine alleviated lipopolysaccharide-induced immunological stress in yellow-feathered broilers

“…Immune stress induced by LPS resulted in compromised growth performance of broilers ( Yang et al., 2011 , Haziak et al., 2014 , Tan et al., 2014 , Fowler et al., 2015 , Zhang et al., 2017 ), which was mainly attributed to reallocation of nutrients. To be specific, diet nutrients were away from growth, but toward processes associated with inflammatory immune response and synthesis of various mediators such as cytokines ( Liu et al., 2015 , Li et al., 2015b ).…”

Effects of berberine on the growth performance, antioxidative capacity and immune response to lipopolysaccharide challenge in broilers

“…Additionally, Kamboh and Zhu () demonstrated that repeated intraperitoneal injections of broilers with LPS at a dose of 0.25 mg/kg BW did not affect the performance of the broilers. Zhang, Shi, et al () found that intraperitoneal infection with a dose of 500 µg LPS per kg BW significantly reduced the value of ADG and ADFI in broilers at 21 days of age. Chen et al () recently showed that 1 mg/kg BW LPS challenge significantly reduced the performance of broilers.…”

“…At 14, 16, 18 and 20 days of age, the broilers from each subgroup of the two treatment groups received an intraperitoneal injection of LPS solution or an equal amount of sterile saline. The LPS dosage, administration route and sampling times adopted in this study were referenced from available findings (Kamboh, Hang, Khan, & Zhu, 2016;Takahashi, Akiba, Iwata, & Kasai, 2015;Zhang, Shi, et al, 2017b;Zheng et al, 2016).…”

Water extract of Artemisia ordosica enhances antioxidant capability and immune response without affecting growth performance in weanling piglets

“…Artemisia species are one of the most popular plants in Chinese traditional herbal medicine and are frequently used for the treatment of diseases such as malaria, hepatitis, cancer, inflammation and infections caused by fungi, bacteria and viruses (Wright, ). Owing to their rich nutrients and bio‐active components, the genus Artemisia plants and their extracts can be used as natural Chinese herbal medicine feed additive, which plays important roles in promoting animal growth performance, improving the quality of animal products and enhancing the immune function and antioxidant activity (Bhakuni, Jain, Sharma, & Kumar, ; Brisibe, Umoren, Owai, & Brisibe, ; Gouveia & Castilho, ; Kim, Adesogan, & Shin, ; Kim et al, ; Li et al, ; Sani, Mohammadi, Sendi, Abolghasemi, & Mehr, ; zhang et al, , ). Among genus Artemisia plants, Artemisia ordosica , a perennial herb, is one of the main shrubs growing in north and northwest areas in China.…”