Remote control of the permeability of the blood–brain barrier by magnetic heating of nanoparticles: A proof of concept for brain drug delivery

Tabatabaei, Seyed Nasrollah; Girouard, Hélène; Carret, Anne‐Sophie; Martel, Sylvain

doi:10.1016/j.jconrel.2015.02.027

Cited by 130 publications

(84 citation statements)

References 32 publications

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“…Although purportedly a noninvasive strategy, it is clear that heating the brain to such a degree is likely detrimental and may increase the risk of infection (Lange and Sedmak, 1991). Other examples of thermally-dependent BBBO include using electromagnetic pulses to disrupt TJs (Qiu et al, 2010) and using a low radiofrequency field to heat magnetic nanoparticles (Tabatabaei et al, 2015). …”

Section: Approaches For Drug Delivery To the Brainmentioning

confidence: 99%

Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound

2017

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The range of therapeutic treatment options for central nervous system (CNS) diseases is greatly limited by the blood-brain barrier (BBB). While a variety of strategies to circumvent the blood-brain barrier for drug delivery have been investigated, little clinical success has been achieved. Focused ultrasound (FUS) is a unique approach whereby the transcranial application of acoustic energy to targeted brain areas causes a noninvasive, safe, transient, and targeted opening of the BBB, providing an avenue for the delivery of therapeutic agents from the systemic circulation into the brain. There is a great need for viable treatment strategies for CNS diseases, and we believe that the preclinical success of this technique should encourage a rapid movement towards clinical testing. In this review, we address the versatile applications of FUS-mediated BBB opening, the safety profile of the technique, and the physical and biological mechanisms that drive this process.

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Section: Approaches For Drug Delivery To the Brainmentioning

confidence: 99%

Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound

2017

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“…Finally in the same year, it was also shown in rat models that the same nanoparticles used to induce a displacement force on nanorobotic agents while providing a means to detect their position using a clinical MRI scanner could also be used to temporary and reversibly open the blood-brain barrier. 59 By embedding this new functionality made possible by exploiting nanotechnology, it allowed precise accesses (at the exact same locations of the navigable agents) to the last physiological regions in the human body that was so far out-of-reach to nanorobotic agents.…”

Section: The Pre-translational Eramentioning

confidence: 99%

Swimming microorganisms acting as nanorobots versus artificial nanorobotic agents: A perspective view from an historical retrospective on the future of medical nanorobotics in the largest known three-dimensional biomicrofluidic networks

Martel

2016

Biomicrofluidics

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The vascular system in each human can be described as a 3D biomicrofluidic network providing a pathway close to approximately 100 000 km in length. Such network can be exploited to target any parts inside the human body with further accessibility through physiological spaces such as the interstitial microenvironments. This fact has triggered research initiatives towards the development of new medical tools in the form of microscopic robotic agents designed for surgical, therapeutic, imaging, or diagnostic applications. To push the technology further towards medical applications, nanotechnology including nanomedicine has been integrated with principles of robotics. This new field of research is known as medical nanorobotics. It has been particularly creative in recent years to make what was and often still considered science-fiction to offer concrete implementations with the potential to enhance significantly many actual medical practices. In such a global effort, two main strategic trends have emerged where artificial and synthetic implementations presently compete with swimming microorganisms being harnessed to act as medical nanorobotic agents. Recognizing the potentials of each approach, efforts to combine both towards the implementation of hybrid nanorobotic agents where functionalities are implemented using both artificial/synthetic and microorganism-based entities have also been initiated. Here, through the main eras of progressive developments in this field, the evolutionary path being described from some of the main historical achievements to recent technological innovations is extrapolated in an attempt to provide a perspective view on the future of medical nanorobotics capable of targeting any parts of the human body accessible through the vascular network.

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“…Several sorts of magnetic nanoparticles have been widely investigated for biomedical applications, among which iron oxide-based magnetic nanoparticles are very promising candidates due to their unique features like biocompatibility, large surface area and superparamagnetic behavior that make them an ideal tool for cell separation, magnetic resonance imaging (MRI) [11][12], cancer treatment by hyperthermia [13][14][15] drug delivery systems (DDS) [16,17]. In all these applications it is necessary to maintain the nanostructure of the individual particles in order to preserve the superparamagnetic behavior.…”

Section: Introductionmentioning

confidence: 99%

2017/1 issue read download 2017/1 – Content Nest-like BaO•6Fe2O3 microspheres with hierarchical porous structure for drug delivery

Torres-Cadenas¹,

Bravo-Patino²,

Zárate‐Medina³

et al. 2017

Epitoanyag - JSBCM

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recent years a surge has been seen in magnetic nanoparticles applications in several areas, particularly in biomedical field. the promising features of the iron oxide based magnetic nanoparticles make them an ideal tool for mri contrast agents, hyperthermia, and as drug delivery systems (DDs). the present paper describes the design and synthesis of Bao·6Fe 2 o 3 nanostructured meso-macroporous spherical aggregates by sol-gel method via spray drying technique. the obtained spherical aggregates have micrometric size, which let them to be carried by the bloodstream to a specific site where the drug is going to be release. the obtained hierarchical porous structure combined with the interconnected mesoporosity allow the body fluids to be transport through the aggregates; and the macroporosity allows the load of large molecules, like peptides. Furthermore, the structural and morphological characterization of the obtained Bao·6Fe 2 o 3 aggregates were carried out using X-ray diffraction and field emission scanning electron microscopy. keywords: nest-like morphology, hierarchical porous structure, drug delivery, barium hexaferrite.

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Remote control of the permeability of the blood–brain barrier by magnetic heating of nanoparticles: A proof of concept for brain drug delivery

Cited by 130 publications

References 32 publications

Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound

Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound

Swimming microorganisms acting as nanorobots versus artificial nanorobotic agents: A perspective view from an historical retrospective on the future of medical nanorobotics in the largest known three-dimensional biomicrofluidic networks

2017/1 issue read download 2017/1 – Content Nest-like BaO•6Fe2O3 microspheres with hierarchical porous structure for drug delivery

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