Renal cell carcinoma metastatic to the gallbladder or prostate: Two case reports

King, D. H.; Centeno, Arthur S.; Saldivar, Victor; Sarosdy, Michael F.

doi:10.1016/s0090-4295(99)80310-0

Cited by 42 publications

(20 citation statements)

References 12 publications

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“…At diagnosis, these renal tumors were notably large, and following metastasis to the prostate, additional sites, including the lung and bone, were also affected. These previous cases indicate that RCC tumor dissemination occurs via hematogenous mechanisms (7,8). In the present study, the immunohistochemical staining results and the absence of detectable continuity between the two tumors supported the diagnosis of a pre-malignant role of nephrogenic carcinoma.…”

Section: Discussionsupporting

confidence: 81%

“…Therefore, it was concluded that the lesion represented a primary renal-type clear cell carcinoma that had arisen from the periurethral region of the prostate, and thus was treated appropriately with a radical cystoprostatectomy. To the best of our knowledge, no previous studies have described RCC presenting with metastases to the prostate at the time of initial diagnosis, but three cases of metachronous prostate involvement by primary RCCs have been reported (7,8). At diagnosis, these renal tumors were notably large, and following metastasis to the prostate, additional sites, including the lung and bone, were also affected.…”

Section: Discussionmentioning

confidence: 97%

“…The most common sites of RCC metastases are the lungs, bone and liver (5,6). However, metastases affecting the lower urinary tract, namely the prostate and bladder, are extremely rare (7,8). In 2012, the worldwide age-standardized mortality rate for RCC was 1.8 deaths per 100,000 individuals (9).…”

mentioning

confidence: 99%

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Renal-type clear cell carcinoma of the prostate: A case report

Wang

Xue

2015

Oncology Letters

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Abstract. Renal-type clear cell carcinoma of the prostate is a rare and novel tumor that has only been identified in recent years. The present study describes a lesion in the prostate of a 64-year-old male with a two-year history of urinary frequency, urgency and difficulty, who was admitted to the San Ai Tang Hospital for benign prostatic hyperplasia, and subsequently underwent transurethral resection of the prostate. In total, 12 g of tissue was resected, which demonstrated morphological and immunohistochemical similarities to clear cell carcinoma of the kidney. Ultrasound inspection and computed tomography revealed prostate enlargement. Although no renal-enclosed mass was identified, metastatic lesions were revealed in the lungs, sternum and clavicles. In addition, right pleural thickening and a small amount of effusion in the pleural cavity were detected. Clear cell carcinoma was identified throughout the prostate, with surrounding regions of ordinary-type prostatic adenocarcinoma (Gleason score, 4+4). The urinary bladder exhibited no dysplasia or neoplasia. It was therefore concluded that the tumor represented a primary renal-type clear cell carcinoma that had arisen in the prostate. To the best of our knowledge, this type of extra-renal tumor has only been reported in three other previous studies. IntroductionClear cell carcinomas that occur in the lower urinary tract are usually variants of more frequently diagnosed cancers, including prostatic adenocarcinoma and transitional cell carcinoma (1), however, they may also be a less common type of carcinoma, such as clear cell carcinoma, which is similar to Müllerian tumors and metastatic renal cell carcinomas (RCCs) (2). RCC is the most common subtype of clear cell carcinoma, which originates from renal tubular epithelial cells and accounts for 85% of all renal tumors (3). Patients with RCC are usually asymptomatic in the early stages of the disease, however, as the tumor size increases patients most commonly present with a lump in the lower abdomen or back, lower back pain and hematuria (4). The most common sites of RCC metastases are the lungs, bone and liver (5,6). However, metastases affecting the lower urinary tract, namely the prostate and bladder, are extremely rare (7,8). In 2012, the worldwide age-standardized mortality rate for RCC was 1.8 deaths per 100,000 individuals (9). At present, treatment for RCC includes radical surgery, immunotherapy and chemotherapy (10). To the best of our knowledge, renal-type clear cell carcinoma occurring as a primary tumor in an extra-renal location has only been described in three other previous studies (11-13) which revealed that RCC of the prostate is a novel pathological entity, that exhibits histological and immunhistochemical features similar to those of RCC. Case reportA 64-year-old male with a two-year history of urinary frequency, urgency and difficulty, that had undergone treatment with a detaining urethral catheter for eight days, was referred to the San Ai Tang Hospital (Lanzhou, China) due to lower urina...

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 97%

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Renal-type clear cell carcinoma of the prostate: A case report

Wang

Xue

2015

Oncology Letters

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“…A clinically discovered, synchronous, isolated, and surgically resected metastatic focus is especially rare, with only one other reported case in the literature [1]. Although metastatic renal cell carcinoma traditionally portends a very poor prognosis, this case supports the concept that resection of isolated, synchronous metastatic lesions, even to unusual landing sites, may improve survival.…”

Section: Introductionsupporting

confidence: 67%

Renal cell carcinoma metastatic to gallbladder: a survival advantage to simultaneous nephrectomy and cholecystectomy

et al. 2007

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Renal cell carcinoma is a relatively uncommon cancer. Patients presenting with a renal adenocarcinoma are often found to have evidence of metastatic disease at the time of diagnosis. Herein, we describe the case of a 39-year-old male with renal cell carcinoma and a synchronous metastatic focus to the gallbladder. The patient underwent a successful simultaneous nephrectomy and cholecystectomy and is doing well 30 months after surgery without evidence of disease recurrence. A thorough metastatic work-up along with aggressive surgical intervention in patients with renal cell carcinoma and unusual metastatic foci can provide a long-term favorable outcome.

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“…The finding of metastasis to the prostate originating from RCC has only been described in the literature 5 times [7][8][9][10][11] ( table 1 ). An appearance of such a lesion 10 years after diagnosis is even rarer.…”

Section: Discussionmentioning

confidence: 99%