Renal Clearance of Essential Amino Acids: Threonine and Phenylalanine

Russo, Horace F.; Wright, Lemuel D.; Skegs, Helen R.; Tillson, Elizabeth K.; Beyer, Karl H.

doi:10.3181/00379727-65-15914

Cited by 20 publications

(4 citation statements)

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“…In part, the conflict has arisen because of the limited specificity of the analytical methods which the earlier investigators were forced to employ (2-7). Beyer and his associates (8)(9)(10)(11)(12), and Kamin and Handler (13), using the more specific methods of microbiological assay, were able to define these areas of conflict as well as to confirm and extend certain of the earlier findings. The most important findings of these previous investigations and the present state of knowledge on this subject might be summarized as follows:…”

supporting

confidence: 68%

Renal Clearance of Eighteen Individual Amino Acids in Human Subjects 1

Doolan¹,

Harper²,

Hutchin³

1955

J. Clin. Invest.

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supporting

confidence: 68%

Renal Clearance of Eighteen Individual Amino Acids in Human Subjects 1

Doolan¹,

Harper²,

Hutchin³

1955

J. Clin. Invest.

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“…One of the main interests in this question has been the possibility of obtaining a Tm value for different amino-acids. Definite Tm values have been claimed for glycine (Pitts, 1943), L-arginine and L-lysine (Wright, Russo, Skeggs, Patch & Beyer, 1947), while it has not been possible to demonstrate definite Tm values for DL-alanine (Goettsch, Lyttle, Grim & Dunbar, 1944), L-histidine and DL-methionine ), L-tryptophane, L-isoleucine, L-leucine and L-valine (Beyer, Wright, Russo, Skeggs & Patch, 1946), DL-threonine, and DL-phenylalanine (Russo, Wright, Skeggs, Tillson & Beyer, 1947). Since a Tm value can only be obtained for a substance which is actively absorbed, it would seem from our results that Tm values are likely to be obtained for L-amino-acids only and not for D-amino-acids or racemic mixtures.…”

Section: Discussionmentioning

confidence: 99%

The excretion of the enantiomorphs of amino‐acids

Crampton¹,

Smyth²

1953

The Journal of Physiology

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“…2Lieutenant Commander, Medical Corps, United States Navy. 8 University of California School of Medicine, San…”

Section: Methodsmentioning

confidence: 99%

The Renal Tubular Response to Amino Acid Loading 1

Doolan¹,

Harper²,

Hutchin³

et al. 1956

J. Clin. Invest.

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In previous studies from this laboratory (1) it was shown that renal tubular reabsorption of filtered amino acids was virtually complete in the fasting state. However, when a solution of amino acids was administered intravenously and the load filtered by the kidney thus increased, both the amounts of amino acids reabsorbed and those excreted were increased. In quantitative terms the more noteworthy event was the increase in amount reabsorbed. Considerable selectivity was exhibited in the reabsorption of individual amino acids and evidence was obtained which was interpreted as indicating a "competition" for reabsorption between cystine and one or more other amino acids.In the present studies the solution of amino acids used for loading was administered at a faster rate than in the previously reported experiments and it was supplemented with additional glycine to test the effects of a further increase in the filtered load of amino acids. In separate studies glycine was administered alone and, in terms of amounts reabsorbed and excreted, the results were compared with those obtained when glycine was given as part of the amino acid mixture and comparable filtered loads were achieved. METHODSThree normal subjects-DNW (age 21, ht. 184.2 cm., wt. 85.5 kg.), WRR (age 28, ht. 175.3 cm., wt. 95.0 kg.), and WS (age 29, ht. 168.9 cm., wt. 60.5 kg.)-were given Merck's 10 per cent solution of free amino acids. The experimental protocol is outlined in Table I-A, the rate of infusion being calculated on a basis of its glycine content. The glomerular filtration rate (GFR) was meas-

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Renal Clearance of Essential Amino Acids: Threonine and Phenylalanine

Cited by 20 publications

References 0 publications

Renal Clearance of Eighteen Individual Amino Acids in Human Subjects 1

Renal Clearance of Eighteen Individual Amino Acids in Human Subjects 1

The excretion of the enantiomorphs of amino‐acids

The Renal Tubular Response to Amino Acid Loading 1

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