Renal function predicts cardiovascular outcomes in southern Italian postmenopausal women

Perticone, Francesco; Sciacqua, Angela; Maio, Raffaele; Perticone, Maria; Laino, Irma; Bruni, Rosamaria; Cello, Serena Di; Leone, Giulia; Greco, Luigi; Andreozzi, Francesco; Sesti, Giorgio

doi:10.1097/hjr.0b013e32832b8d87

Cited by 13 publications

(9 citation statements)

References 26 publications

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“…Renal dysfunction is a worldwide health problem as a consequence of its adverse outcomes including cardiovascular events and all-cause-mortality [1]–[3]. Increasing evidence suggests that chronic kidney disease (CKD), defined as a sustained reduction in the glomerular filtration rate (GFR), and cardiovascular disease share common risk factors such as the metabolic syndrome and its individual components (elevated blood pressure, high plasma glucose levels, high triglycerides levels, low high density lipoprotein (HDL) levels, and abdominal obesity) [4]–[6].…”

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confidence: 99%

Association between Noninvasive Fibrosis Markers and Chronic Kidney Disease among Adults with Nonalcoholic Fatty Liver Disease

et al. 2014

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Evidence suggests that nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are associated with an increased risk of chronic kidney disease (CKD). In this study we aimed to evaluate whether the severity of liver fibrosis estimated by NAFLD fibrosis score is associated with higher prevalence of CKD in individuals with NAFLD. To this end NAFLD fibrosis score and estimated glomerular filtration rate (eGFR) were assessed in 570 White individuals with ultrasonography-diagnosed NAFLD. As compared with subjects at low probability of liver fibrosis, individuals at high and intermediate probability showed an unfavorable cardio-metabolic risk profile having significantly higher values of waist circumference, insulin resistance, high sensitivity C-reactive protein, fibrinogen, uric acid and lower insulin-like growth factor-1 levels. Individuals at high and intermediate probability of liver fibrosis have lower eGFR after adjustment for gender, smoking, glucose tolerance status, homeostasis model assessment index of insulin resistance (HOMA-IR index), diagnosis of metabolic syndrome, statin therapy, anti-diabetes and anti-hypertensive treatments (P = 0.001). Individuals at high probability of liver fibrosis had a 5.1-fold increased risk of having CKD (OR 5.13, 95%CI 1.13–23.28; P = 0.03) as compared with individuals at low probability after adjustment for age, gender, and BMI. After adjustment for glucose tolerance status, statin therapy, and anti-hypertensive treatment in addition to gender, individuals at high probability of liver fibrosis had a 3.9-fold increased risk of CKD (OR 3.94, 95%CI 1.11–14.05; P = 0.03) as compared with individuals at low probability. In conclusion, advanced liver fibrosis, determined by noninvasive fibrosis markers, is associated with CKD independently from other known factors.

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Section: Introductionmentioning

confidence: 99%

Association between Noninvasive Fibrosis Markers and Chronic Kidney Disease among Adults with Nonalcoholic Fatty Liver Disease

et al. 2014

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“…In addition, in hypertensive patients, the 1-h post-load plasma glucose value was strongly associated with different subclinical organ damage [20-24] thus increasing risk for future cardiovascular events [25-27]. …”

Section: Introductionmentioning

confidence: 99%

Vitamin D and 1-hour post-load plasma glucose in hypertensive patients

Sciacqua

Perticone

Grillo

et al. 2014

Cardiovasc Diabetol

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BackgroundA plasma glucose value ≥155 mg/dl for 1-hour post-load plasma glucose during an oral glucose tolerance test (OGTT) is able to identify subjects with normal glucose tolerance (NGT) at high-risk for type-2 diabetes and with subclinical organ damage. We designed this study to address if 25-hydroxyvitamin D [25(OH)D] circulating levels are associated with glucose tolerance status, and in particular with 1-hour post-load plasma glucose levels.MethodsWe enrolled 300 consecutive Caucasian hypertensive never-treated outpatients (160 men and 140 women, aged 52.9 ± 9.2 years). Subjects underwent OGTT and measurements of 25(OH)D and standard laboratory tests. Estimated glomerular filtration rate (e-GFR) was calculated by CKD-EPI formula and insulin sensitivity was assessed by Matsuda-index.ResultsAmong participants, 230 were NGT, 44 had impaired glucose tolerance (IGT) and 26 had type-2 diabetes. According to 1-h post-load plasma glucose cut-off point of 155 mg/dL, we divided NGT subjects into: NGT < 155 (n = 156) and NGT > 155 mg/dL (n = 74).NGT ≥ 155 had higher significant fasting and post-load glucose and insulin, parathyroid hormone and hs-CRP levels than NGT < 155. On the contrary, Matsuda-index, e-GFR, and 25(OH)D were significantly lower in NGT ≥ 155 than NGT < 155 subjects. In the multiple regression analysis, 25(OH)D levels resulted the major determinant of 1-h post-load plasma glucose in all population and in the four groups of glucose tolerance status. In the whole population, Matsuda-index, hs-CRP and e-GFR explained another 12.2%, 6.7% and 1.7% of its variation.ConclusionsOur data demonstrate a significant and inverse relationship between 25(OH)D levels and glucose tolerance status, particularly with 1-h post-load glucose.

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“…It is well known that post-menopausal women have an increased CV risk (8); in particular, the reduction of renal function has been associated with the increased risk of death and CV events, independently of traditional CV risk factors, menopause duration, and presence of metabolic syndrome (9). In addition, serum UA levels appear to be increased in both physiologic and post-surgical menopause independently of other confounding factors (10).…”

Section: Introductionmentioning

confidence: 98%

Uric acid is an independent predictor of cardiovascular events in post-menopausal women

Sciacqua

Perticone

Tassone

et al. 2015

International Journal of Cardiology

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Renal function predicts cardiovascular outcomes in southern Italian postmenopausal women

Abstract: For the first time, we demonstrated that the reduction of e-GFR was associated with the increased risk of death and CV events, independently of traditional CV risk factors, menopause duration, and presence of metabolic syndrome.

Cited by 13 publications

References 26 publications

Association between Noninvasive Fibrosis Markers and Chronic Kidney Disease among Adults with Nonalcoholic Fatty Liver Disease

Association between Noninvasive Fibrosis Markers and Chronic Kidney Disease among Adults with Nonalcoholic Fatty Liver Disease

Vitamin D and 1-hour post-load plasma glucose in hypertensive patients

Uric acid is an independent predictor of cardiovascular events in post-menopausal women

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