Renal, Haemodynamic, and Hormonal Effects of Human Alpha Atrial Natriuretic Peptide in Healthy Volunteers

Richards, A. Mark; Ikram, Hamid; Yandle, Timothy G.; Nicholls, M. Gary; Webster, Mark; Espiner, Eric A.

doi:10.1016/s0140-6736(85)91207-3

Cited by 411 publications

(114 citation statements)

References 20 publications

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“…Although blood pressure was not changed, total peripheral resistance decreased markedly, and GFR increased. Since fractional excretions of water and sodium were not changed, the main mechanism of action of a-hANP seems to increase renal blood flow secondary to the decreased renal vascular resistance as previously reported in normal subjects and hypertensive subjects (Richards et al 1985 ;Ishii et al 1986;Weidmann et al 1986). As implied in previous studies, a-hANP increased GFR secondary to the increased renal blood flow, though renal blood flow was not measured in this study.…”

Section: Commentssupporting

confidence: 63%

“…Recently, atrial natriuretic polypeptide (ANP) has been shown to have potent natriuretic and vasodilating action in man (Kangawa and Matsuo 1984;Richards et al 1985 ;Ishii et al 1986;Weidmann et al 1986). We report the effect of ANP on hemodynamics and renal function after the reconstructive surgery of the left renal artery in a patient with renovascular hypertension secondary to Takayasu's…”

mentioning

confidence: 99%

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Atrial natriuretic polypeptide(ANP) as protective agent of renal ischemia.

Omata

Matsui

Sato

et al. 1989

Tohoku J. Exp. Med.

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Natriuretic Polypeptide (ANP) as Protective Agent of Renal Ischemia. Tohoku J. Exp. Med., 1989, 158 (4), [283][284][285][286][287][288][289] The effect of atrial natriuretic polypeptide (ANP) on hemodynamics and renal function was evaluated after the reconstructive surgery of the left renal artery in a patient with renovasular hypertension secondary to Takayasu's arteritis. The reconstructive surgery was done using the femoral artery, since we were unable to obtain adequate vein segments to fit the renal artery. The femoral artery was reconstructed by her saphenous vein segments. After 30 min of the aortorenal bypass operation, a-human ANP (ahANP) was infused intravenously for 10 min at a rate of 0.1pg/kg/min. Although total peripheral resistance was decreased by a-hANP infusion, blood pressure was not changed because of the increased cardiac output. Glomerular filtration rate was increased markedly with concomitant increases in urine volume and urinary excretions of sodium, potassium and phosphate. Fractional excretions of water and sodium were not changed, but fractional excretion of phosphate and potassium clearance were increased. Thus, the infusion of a-hANP markedly improved the renal function of the ischemic kidney by the reconstructive surgery of the renal artery, suggesting that a-hANP seems clinically applicable as a protective agent in renal ischemia at renovascular surgery as well as the renal transplantation.atrial natriuretic polypeptide (ANP) ; renal ischemia ; renovascular hypertension ; reconstructive surgery It is extremely important to avoid the ischemic renal damage for the preservation of renal function at the reconstructive surgery of the renal artery. Recently, atrial natriuretic polypeptide (ANP) has been shown to have potent natriuretic and vasodilating action in man (Kangawa and Matsuo 1984;Richards et al. 1985 ;Ishii et al. 1986;Weidmann et al. 1986). We report the effect of ANP on hemodynamics and renal function after the reconstructive surgery of the left renal artery in a patient with renovascular hypertension secondary to Takayasu's

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Section: Commentssupporting

confidence: 63%

mentioning

confidence: 99%

Atrial natriuretic polypeptide(ANP) as protective agent of renal ischemia.

Omata

Matsui

Sato

et al. 1989

Tohoku J. Exp. Med.

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“…Similar changes in renal function and electrolyte excretion after ANF have been found in human studies by others. 10 ' "• 24 An increase in maximal free water clearance and lithium clearance has also been observed in dogs. 2526 Notwithstanding the many uncertainties inherent in these clearance techniques, these results suggest that the increased sodium excretion observed after ANF involved a rise in the filtered load and a fall in fractional reabsorption in both proximal and distal nephron segments.…”

Section: Discussionmentioning

confidence: 96%

Enalapril attenuates natriuresis of atrial natriuretic factor in humans.

Gaillard¹,

Koomans²,

Mees³

1988

Hypertension

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. Under these conditions baseline sodium excretion was not different from the control study, but it rose less after ANF (from 117 ± 22 to 242 ± 63 /umol/min), and the increments in glomerular nitration rate, free water clearance, phosphate, lithium, uric add, and magnesium were all blunted and nonsignificant. In addition, effective renal plasma flow tended to fall; this effect was not observed when ANF was given without enalapril. These results support the notion that the effects of ANF on renal hemodynamics and on tubular sodium handling depend on renal angiotensln II and that blood pressure reduction may interfere with the ANF-induced natriuresis. (Hypertension 11:160-165,1988)

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“…Esta inibição, induzida pela administração de SH e SHD, deve ocorrer devido à rápida correção da hipovolemia e da instalação de moderada hiperosmolaridade plasmática. Richards e col. 26 sugeriram que a liberação do hormônio natriurético atrial seria responsável por esta magnitude de aumento na diurese. No entanto, não foi encontrada elevação dos níveis séricos do peptídeo natriurético atrial em reposta à injeção de SHD 27,28 .…”

Section: Discussionunclassified

“…This HS and HSD-induced inhibition might occur due to the fast hypovolemia correction and the installation of mild plasma hyperosmolarity. Richards et al 26 have suggested that atrial natriuretic hormone release would be the cause for this magnitude in diure- sis increase. However, no increase in atrial natriuretic peptide serum levels was observed in response to HSD injection 27,28 .…”

Section: Discussionmentioning

confidence: 99%