2017
DOI: 10.23876/j.krcp.2017.36.2.117
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Renal sodium handling and sodium sensitivity

Abstract: The pathophysiology of hypertension, which affects over 1 billion individuals worldwide, involves the integration of the actions of multiple organ systems, including the kidney. The kidney, which governs sodium excretion via several mechanisms including pressure natriuresis and the actions of renal sodium transporters, is central to long term blood pressure regulation and the salt sensitivity of blood pressure. The impact of renal sodium handling and the salt sensitivity of blood pressure in health and hyperte… Show more

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Cited by 23 publications
(21 citation statements)
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“…The pressure–natriuresis (PN) relationship explains the central role of the kidney in the pathogenesis of hypertension [ 5 ]. In chronic kidney disease (CKD), the ability to increase urinary sodium chloride (NaCl) excretion in response to high salt intake is diminished.…”
Section: Introductionmentioning
confidence: 99%
“…The pressure–natriuresis (PN) relationship explains the central role of the kidney in the pathogenesis of hypertension [ 5 ]. In chronic kidney disease (CKD), the ability to increase urinary sodium chloride (NaCl) excretion in response to high salt intake is diminished.…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, sodium has a major role in driving electrochemical forces that support kidney primary role in fine-tuning body composition. Sodium reabsorption and excretion results from the integration of a complex network of sensors, neural-hormonal stimuli and hemodynamic and metabolic mechanisms ( Frame and Wainford, 2017 ).…”
Section: Insulin Tubular Actionsmentioning
confidence: 99%
“…Salt sensitivity is the genetic basis of salt connects hypertension, is an intermediate genetic phenotype of essential hypertension. The salt sensitivity of blood pressure, defined as an exaggerated pressor response to dietary salt intake, jointly determined by genetic factors, age, body mass index (BMI), concomitant diseases, ethnic factor, increases the risk of hypertension (Carey et al, 2012; Kotchen et al, 2013;Felder et al, 2013;Frame et al, 2017), and the associated hypertension defined as salt sensitivity hypertension (salt-sensitive hypertension, SSH). Some people have significant blood pressure increase after high salt intake is called salt-sensitive subjects, while the other group have no obvious increase in blood pressure is called non-salt-sensitive subjects.…”
Section: Salt-sensitive Hypertensionmentioning
confidence: 99%