Renal tissue oxygenation in children with chronic kidney disease due to vesicoureteral reflux

Chehade, Hassib; Milani, Bastien; Ansaloni, Annalisa; Anex, Christiane; Bassi, Isabelle; Piskunowicz, Maciej; Stuber, Matthias; Cachat, François; Burnier, Michel; Pruijm, Menno

doi:10.1007/s00467-016-3419-0

Cited by 6 publications

(5 citation statements)

References 43 publications

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“…The renal cortical and medullary oxygen partial pressures are approximately 50 mmHg and 10-20 mmHg, respectively [16]. However, the R2* values of renal cortex and medulla in the present study were lower than those in adults in the studies of Chehade et al [8] and Prasad et al [17]. This difference might be related to the younger age of the participants in our study.…”

Section: Discussioncontrasting

confidence: 69%

“…However, BOLD-MRI is rarely used in children with kidney disease. Only Chehade et al [8] applied BOLD-MRI to evaluate renal function in children with CKD caused by vesicoureteral reflux. This study performed BOLD-MRI examination of kidneys using 1.5-T MRI in children with CKD to investigate the differences in renal cortical and medullary R2* values among different CKD stages, and the relationship between renal cortical and medullary R2* values and renal function indexes in children with CKD and to provide baseline data for the further use of renal BOLD-MRI in children with CKD.…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive evaluation of renal oxygenation in children with chronic kidney disease using blood-oxygen-level-dependent magnetic resonance imaging

et al. 2020

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Background Renal hypoxia is considered a final pathway in the progression of chronic kidney disease (CKD). Blood-oxygenlevel-dependent magnetic resonance imaging (BOLD-MRI) has shown merit for evaluating renal oxygenation in adults.Objective To investigate renal cortical and medullary R2* values by CKD stage and by renal function index in children with chronic kidney disease. Materials and methods Twenty-one children with CKD Stage 1-3, 16 children with CKD Stage 4-5, and 6 healthy volunteers underwent a renal MRI using multigradient recalled-echo sequence with 16 echoes. We measured the R2* values of the renal cortex and medulla on BOLD-MRI. Results The cortical R2* value was ranked as CKD Stage 4-5 > CKD Stage 1-3 > healthy controls, and the medullary R2* value was ranked as CKD Stage 4-5 > CKD Stage 1-3. There was no significant difference in the medullary R2* value between CKD Stage 1-3 patients and the healthy controls. There was a positive correlation between the R2* values in the renal cortex (r=0.73) and medulla (r=0.89), and the serum creatinine level (P<0.001), and the renal cortical and medullary R2* values were negatively correlated with the estimated glomerular filtration rate (r=-0.71 and r=-0.89, respectively; P<0.001). Conclusion BOLD-MRI might contribute to noninvasive assessment of renal oxygenation in children with CKD in vivo but it did not reflect renal function in our sample.

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Section: Discussioncontrasting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Noninvasive evaluation of renal oxygenation in children with chronic kidney disease using blood-oxygen-level-dependent magnetic resonance imaging

et al. 2020

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“…There is no question that BOLD-MRI measurements of oxygenation in kidney and heart, limited as they are, have made a significant impact on clinical research and raised fascinating technical and clinical questions. In the kidney, for example, BOLD-MRI has confirmed abnormal oxygen supply and/or oxygenation occurs in unilateral ureter obstruction [ 121 , 122 ], tissue hyperglycaemia, hypertension and CKD [ 4 , 123 , 124 ]. Correlations between cortical rates of deoxygenated haemoglobin, male gender, glycaemia and uric acid levels suggest that these factors interfere with the regulation of renal tissue oxygenation and warrant exploration with hyperpolarized methods [ 123 ].…”

Section: Future Directions and Challengesmentioning

confidence: 99%

Imaging oxygen metabolism with hyperpolarized magnetic resonance: a novel approach for the examination of cardiac and renal function

Schroeder

Laustsen

2017

Bioscience Reports

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Every tissue in the body critically depends on meeting its energetic demands with sufficient oxygen supply. Oxygen supply/demand imbalances underlie the diseases that inflict the greatest socio-economic burden globally. The purpose of this review is to examine how hyperpolarized contrast media, used in combination with MR data acquisition methods, may advance our ability to assess oxygen metabolism non-invasively and thus improve management of clinical disease. We first introduce the concept of hyperpolarization and how hyperpolarized contrast media have been practically implemented to achieve translational and clinical research. We will then analyse how incorporating hyperpolarized contrast media could enable realization of unmet technical needs in clinical practice. We will focus on imaging cardiac and renal oxygen metabolism, as both organs have unique physiological demands to satisfy their requirements for tissue oxygenation, their dysfunction plays a fundamental role in society’s most prevalent diseases, and each organ presents unique imaging challenges. It is our aim that this review attracts a multi-disciplinary audience and sparks collaborations that utilize an exciting, emergent technology to advance our ability to treat patients adversely affected by an oxygen supply/demand mismatch.

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“…12 ROIs were drawn on the b = 50 s/mm 2 images, including the upper, middle and lower poles of cortex and medulla on both kidneys. ROIs 20-24mm 2 in size 37 , 38 were positioned the on the b = 50 s/mm 2 image (Fig. 5 A,B), and then copied to the ADC map for ADC measurements (Fig.…”

Section: Methodsmentioning

confidence: 99%

Comparing the clinical utility of single-shot, readout-segmented and zoomit echo-planar imaging in diffusion-weighted imaging of the kidney at 3 T

Liu

Xie

et al. 2022

Sci Rep

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We compared the clinical utility of single-shot echo-planar imaging (SS-EPI) using different breathing schemes, readout-segmented EPI and zoomit EPI in the repeatability of apparent diffusion coefficient (ADC) measurements, cortico-medullary contrast to noise ratio (c-mCNR) and image quality. In this institutional review board-approved prospective study, some common clinically applicable diffusion-weighted imaging (b = 50, 400, 800 s/mm2) of kidney on 3.0 T MRI were performed on 22 volunteers using SS-EPI with breath-hold diffusion-weighted imaging (BH-DWI), free-breathing (FB-DWI), navigator-triggered (NT-DWI) and respiratory-triggered (RT-DWI), readout-segmented DWI (RS-DWI), and Zoomit DWI (Z-DWI). ADC and c-mCNR were measured in 12 anatomic locations (the upper, middle, and lower pole of the renal cortex and medulla), and image quality was assessed on these DWI sequences. A DWI with the optimal clinical utility was decided by systematically assessing the ADC repeatability, c-mCNR and image quality among the DWIs. For ADC measurements, Z-DWI had an excellent intra-observer agreement (intra-class correlation coefficients (ICCs): 0.876–0.944) and good inter-observer agreement (inter-class ICCs: 0.798–0.856) in six DWI sequences. Z-DWI had the highest ADC repeatability in most of the 12 anatomic locations of the kidneys (mean ADC absolute difference: 0.070–0.111 × 10−3 mm2/s, limit of agreement: 0.031–0.056 × 10−3 mm2/s). In all DWIs, Z-DWI yielded a slightly higher c-mCNR than other DWIs in most representative locations (P > 0.05), which was significantly higher than BH-DWI and FB-DWI in the middle pole of both kidneys and the upper pole of the left kidney (P < 0.05). In addition, Z-DWI yielded image quality that was similar to RT-DWI and NT-DWI (P > 0.05) and superior to BH-DWI, FB-DWI and RS-DWI (P < 0.05). Our results suggest that Z-DWI provides the highest ADC reproducibility, better c-mCNR and good image quality on 3.0 T MRI, making it the recommended sequence for clinical DWI of the kidney.

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Renal tissue oxygenation in children with chronic kidney disease due to vesicoureteral reflux

Cited by 6 publications

References 43 publications

Noninvasive evaluation of renal oxygenation in children with chronic kidney disease using blood-oxygen-level-dependent magnetic resonance imaging

Noninvasive evaluation of renal oxygenation in children with chronic kidney disease using blood-oxygen-level-dependent magnetic resonance imaging

Imaging oxygen metabolism with hyperpolarized magnetic resonance: a novel approach for the examination of cardiac and renal function

Comparing the clinical utility of single-shot, readout-segmented and zoomit echo-planar imaging in diffusion-weighted imaging of the kidney at 3 T

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