Renal Tubule Development in Drosophila

Jung, Alain C.; Denholm, Barry; Skaer, Helen; Affolter, Markus

doi:10.1681/asn.2004090729

Cited by 79 publications

(80 citation statements)

References 26 publications

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“…Bartolomaeus (1999) showed that mitoses are responsible for at least part of the growth observed in developing nephridia. However, changes of cell shape or integration of cells from other sources, as shown for Malpighian tubules (Jung et al, 2005), might be involved as well.…”

Section: Increasing Structural Complexity Indicates Local Guiding Cuementioning

confidence: 99%

Three consecutive generations of nephridia occur during development of Platynereis dumerilii (Annelida, Polychaeta)

Hasse

Rebscher

Reiher

et al. 2010

Developmental Dynamics

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*Molecular data for nephridial development in polychaetes are not available yet. The scope of our work was to establish a reference system for future investigations using two markers for nephridial development: b-tubulin as marker for cilia and alkaline phosphatase (AP) activity for secretory epithelia. The markers identified, unexpectedly, three consecutively forming generations of nephridia: (1) a transitory unciliated, but AP-positive head kidney, (2) a transitory larval nephridium, which undergoes a morphological transition from a protonephridium to a funnelled nephridium concomitant with the development of the coelomic cavity and finally, (3) the serially arranged metanephridia. The spatial arrangement of larval and definitive nephridia, revealed an up to now unknown developmental boundary between the synchronously forming larval and the serially proliferating definitive segments. Development of three consecutive sets of nephridia with different morphology and biochemical properties was unexpected and reveals an interesting multistep process in the development of excretory structures in Platynereis.

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Section: Increasing Structural Complexity Indicates Local Guiding Cuementioning

confidence: 99%

Three consecutive generations of nephridia occur during development of Platynereis dumerilii (Annelida, Polychaeta)

Hasse

Rebscher

Reiher

et al. 2010

Developmental Dynamics

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show abstract

“…Removal of Dvl, Vangl and prickle orthologs results in convergent extension defects during neurulation, cochlear formation and gastrulation, indicating that PCP signaling is required for these morphogenetic movements in vertebrates [93][94][95][96][97][98][99]. Cell intercalation has not been demonstrated during the development of the mouse kidney tubules although it does occur during the development of the fly Malpighian tubules [100]. So, it seems plausible that defects in PCP signaling could result in defects in the orientation of cell division and, possibly, in the intercalation of cells during kidney growth, resulting in tubules with an increased diameter.…”

Section: Pathway Usage In Renal Vesicle Formationmentioning

confidence: 99%

Molecular regulation of kidney development: is the answer blowing in the Wnt?

2007

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Development of the metanephric kidney is a complicated process regulated by reciprocal signals from the ureteric bud and the metanephric mesenchyme that regulate tubule formation and epithelial branching morphogenesis. Over the past several years, several studies have suggested that Wnt signaling is involved in multiple aspects of normal kidney development as well as injury response and cancer progression. We will review these data here.

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“…12 This process leads to the formation of elongated structures, variable in number, formed by a monolayer epithelium that can be composed of one or two cell types. These processes are well described for Drosophila, where four tubules originate from the hindgut primordium.…”

Section: Embryonic Origin and Larval Periodmentioning

confidence: 99%

“…These vastly different animals share some similar characteristic features during renal tubular development. 6 Vertebrate kidneys are derived through the mutual induction of the ureteric bud and metanephric mesoderm, and have the capacity to recover and regenerate following episodes of acute injury. The MTs of Drosophila, however, develop from the hindgut primordium and visceral mesoderm.…”

mentioning

confidence: 99%