Renal Venous Thrombosis of the Newborn and its Relation to Maternal Diabetes

Sonographic Findings in Fetal Renal Vein Thrombosis

“…In these reports, pathologic examination of the fetal kidney showed branching vascular calcifications, which corresponded to the streaks seen on sonography. In additional autopsy studies, some of the thrombosed intrarenal veins had evidence of recanalization 4 , 8 , 23 …”

“…Scattered case reports support the concept that renal vein thrombosis in the fetus may be responsible for a number of cases diagnosed in the neonatal period, 4 , 5 and several authors have suggested that many cases of neonatal renal vein thrombosis might be better termed “perinatal.” 6 , 7 Although neonatal sonographic findings are well described in the imaging literature, there is a paucity of information about the findings in prenatal renal vein thrombosis. Fetal renal vein thrombosis identified at autopsy has been reported as far back as 1961 8 as well as subsequently 9 . Case reports of fetal renal vein thrombosis found at sonography date as far back as 1989, many of which were diagnosed postnatally with the prenatal imaging findings reviewed retrospectively.…”

The Infant of the Diabetic Mother

“…Although Pedersen failed to mention this condition in his monograph, (22) in one postmortem survey of 16 cases of neonatal renal vein thrombosis, five were found in IDMs. (105) Seven other affected neonates were born to mothers without known diabetes, but the infants had fetal macrosomia and pancreatic beta-cell hypertrophy and hyperplasia. Another center reported a case of an IDM who had nearly a totally occlusive thrombosis in the umbilical vein.…”

Effect of Hyperinsulinemia on the Development of Blood Coagulation in the Lamb Fetus

“…Oppenheimer and Esterly (1) rcportcd a 15.8% incidence of venous thrombosis in 45 newborn infants of diabctic mothcrs. licnal vein thrombosis is the most common thrombotic complication in infants of diabetic mothers (2,3). More recently, Van Allen et (11.…”