Renin–angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study

Conen, David; Glynn, Robert J.; Buring, Julie E.; Ridker, Paul M.; Zee, Robert Y.L.

doi:10.1111/j.1365-2796.2007.01894.x

Cited by 13 publications

(9 citation statements)

References 44 publications

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“…Another potential explanation is that high BP levels cause microvascular dysfunction that precede islet cell failure as shown in animal models 14; in epidemiological studies, biomarkers of endothelial dysfunction independently predict T2DM 15,16. Alternatively BP and T2DM could share a common gene polymorphism; for example, the renin-angiotensin system gene polymorphism associated with essential hypertension 17 has also been associated with increased risk for T2DM 18,19, although these results were not replicated in other studies20,21.…”

Section: Discussionmentioning

confidence: 99%

Mid-life blood pressure levels and the 8-year incidence of type 2 diabetes mellitus: the Rancho Bernardo Study

2009

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Type 2 diabetes mellitus (T2DM) and hypertension frequently occur together. We examined whether blood pressure (BP) levels predict eight-year incident diabetes. Participants were community-dwelling older adults who had BP measured twice and an oral glucose tolerance test at baseline and again 8.3 years later. At baseline, participants were classified as normotensive [systolic (SBP) <120 mmHg and diastolic (DBP) <80 mmHg; n=242]; prehypertensive (SBP ≥120 and <140 mmHg or DBP ≥80 and <90 mmHg; n=426); or hypertensive (SBP ≥140 mmHg or DBP ≥90 mmHg or using anti-hypertensive medication; n=457). There were 1125 participants (mean age 66.0 years; 44.3% men) who attended the baseline and follow-up visit, of whom 85 had new onset T2DM. Participants who developed T2DM had higher mean body mass index (BMI) and BP levels than those who did not develop diabetes. In logistic regression models adjusted for age, sex, BMI, and physical activity, the odds of incident T2DM was greater in prehypertensives (OR2.32 95%CI 1.05–5.1, P=0.03) and hypertensives (OR3.5 95%CI 1.50–8.0, P=0.002) compared to normotensives. Excluding participants who used anti-hypertensive medications did not change results. In conclusion, mid-life hypertension and prehypertension predicted future diabetes, independent of BMI. Glucose surveillance should be encouraged in adults with prehypertension or hypertension.

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Section: Discussionmentioning

confidence: 99%

Mid-life blood pressure levels and the 8-year incidence of type 2 diabetes mellitus: the Rancho Bernardo Study

2009

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“…The genetic marker selection of 42 candidate genes was based on previous evidence of their potential functionality in pathways of inflammation, thrombosis, homeostasis, neurohormonal activation and endothelial dysfunction (8, 9). Further, a validated allele frequency and heterozygosity, and sequence-proven allelic variation were considered for this current analysis.…”

Section: Methodsmentioning

confidence: 99%

“…Genetic variants in pathways related to inflammation, thrombosis, homeostasis, neurohormonal activation and endothelial dysfunction may represent potential risk factors for the MetS (8–10). Although previous studies have shown genetic associations for many of the components of the MetS, few genome wide linkage studies have examined the full MetS (9–13). Recent candidate-gene association studies have studied polymorphisms in candidate genes for CVD in the context of the MetS and its components;(14–17) however, no polymorphisms have been consistently replicated.…”

Section: Introductionmentioning

confidence: 99%

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Association of genetic variants with the metabolic syndrome in 20,806 white women: The women's health genome study

Goulart

Cheng

Rose

et al. 2009

American Heart Journal

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“…However, Conen et al (38) identified no association between NOS3 rs1800779 and NOS3 rs3918226 polymorphisms and occurrence of T2D on a total of 24,309 Caucasian women free of diabetes at baseline in a prospective cohort study (37). In a meta-analysis performed by Zintzaras et al (39), a significant association was revealed between endothelial NO synthase gene polymorphisms (G894T) and diabetic nephropathy on 7,401 cases and 8,046 controls.…”

Section: Discussionmentioning

confidence: 97%

Association of nitric oxide synthase 3 gene polymorphism with the risk of type 2 diabetes

2017

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Abstract. Type-2 diabetes (T2D) is a multifactorial (environmental and genetic factors) and global epidemic disease with an estimated high prevalence worldwide. Studies have indicated that nitric oxide synthase 3 (NOS3) has several important roles in the pathogenesis of T2D. The present study aims to investigate the association between NOS3 rs1800779(A/G) and T2D in an Iranian sample population. A case-control study was conducted on 250 T2D patients and 250 healthy control subjects (HCs). Genotyping of the rs1800779(A/G) variant was conducted using a Tetra-Amplification Refractory Mutation System polymerase chain reaction. The frequencies of genotypes AA, AG and GG polymorphisms were 56.8, 39.2 and 4% in the T2D group, and 42.8, 56 and 1.2% in the HCs group, respectively. The frequency of the minor (G) allele was 23.6% in the T2D group and 29.2% in the HCs group. The genotype frequencies of the rs1800779(A/G) variant demonstrated statistically significant differences between T2D and controls in a codominant model (AG vs. AA, OR=0.527, 95% CI=0.368-0.756, P<0.001) and dominant model (AG+GG vs. AA, OR=0.569, P=0.002). There was no significant association between clinical and demographic characteristics and the NOS3 rs1800779(A/G) polymorphism in dominant status (P>0.05). The dominant model and AG genotype of NOS3 rs1800779(A/G) polymorphism may had a protective effect on T2D of Iranian population.

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Renin–angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study

Cited by 13 publications

References 44 publications

Mid-life blood pressure levels and the 8-year incidence of type 2 diabetes mellitus: the Rancho Bernardo Study

Mid-life blood pressure levels and the 8-year incidence of type 2 diabetes mellitus: the Rancho Bernardo Study

Association of genetic variants with the metabolic syndrome in 20,806 white women: The women's health genome study

Association of nitric oxide synthase 3 gene polymorphism with the risk of type 2 diabetes

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