Renin Levels in Nephroblastoma (Wilms' Tumour): Report of a Renin Secreting Tumour

Mitchell, John D.; Baxter, Thelma J.; Blair‐West, J. R.; McCredie, David A.

doi:10.1136/adc.45.241.376

Cited by 121 publications

(17 citation statements)

References 22 publications

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“…The values are very high in comparison with the range of plasma renin concentration (0-95 + 0-51 (s.d.) ng/h/ml, = 158) in normal sheep (Blair-West, Coghlan, Dentón, Funder, Scoggins & Wright, 1971), and similar to or above the range of plasma renin concentration in normal man (10-35 ng/ h/ml; Mitchell, Baxter, Blair-West & McCredie, 1970) using precisely the same procedure. A substrate concentration of approximately 650 ng/ml, which was two to four times that used for estimations of plasma renin activity or plasma renin con¬ centration with marsupial substrates, was employed for the determination of plasma renin concentration with sheep renin-substrate.…”

Section: Renal Renin Concentrationmentioning

confidence: 81%

Renin Levels in the Kangaroo, the Wombat and Other Marsupial Species

Simpson¹,

Blair‐West²

1971

Journal of Endocrinology

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A renin-angiotensin system was shown to be present in several marsupial species in plasma and homogenates of the renal cortex. Species studied were: Eastern Grey kangaroo (Macropus giganteus), Red kangaroo (Megaleia rufa), common wombat (Vombatus hirsutus), pademelon (Thylogale billardierii), Bennett's wallaby (Wallabia rufogrisea frutica), a quokka (Setonix brachyurus) and a tiger cat (Dasyurus maculatus). Renin-substrate was found in the plasma of the Eastern Grey kangaroo, the Red kangaroo and the wombat. Renin was shown to be present in the plasma of all species by incubation alone or with heterologous marsupial renin-substrate. Plasma renin concentration and renal renin content were estimated by an established method using standard sheep renin-substrate. Plasma renin concentration was high, suggesting that marsupial renins have a high affinity for sheep substrate; renal renin estimates were low relative to eutherian species, suggesting that renal storage may be small. Plasma renin concentration and renal renin levels were proportionately related. Renin levels were consistently lowest in the wombat. Bilateral nephrectomy of an Eastern Grey kangaroo reduced plasma renin concentration to zero and increased renin-substrate concentration eightfold. The angiotensin-like incubation product from Eastern Grey kangaroo renin-substrate did not cross react with antibodies to [5-Ile]-angiotensin I, suggesting that the product has a different sequence of amino acids.

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Section: Renal Renin Concentrationmentioning

confidence: 81%

Renin Levels in the Kangaroo, the Wombat and Other Marsupial Species

Simpson¹,

Blair‐West²

1971

Journal of Endocrinology

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“…1 Juxtaglomerular cell tumors are commonly associated with hypertension, secondary aldosteronism and hypokalemia. 1 Although both renal 3,4 and extrarenal 5-10 renin-secreting neoplasms have been reported, such tumors usually arise in the kidney from the juxtaglomerular apparatus. Diagnosis of juxtaglomerular cell tumors is not always easy, and the tumors can be small and distally located in the renal cortex.…”

Section: Discussion Of Diagnosismentioning

confidence: 99%

A patient with a juxtaglomerular cell tumor with histological vascular invasion

et al. 2008

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“…In search of different possible causes of hyperreninemia (i.e. malig nant hypertension, renal artery stenosis, inappropriate renin secretion by other tumors such as bronchogenic car cinoma [4], Wilms tumor [5,6], or hypernephroma [7][8][9], captopril treatment [10]) a renal tumor may or may not be found.…”

Section: Discussionmentioning

confidence: 99%

Juxtaglomerular Cell Tumor: Importance of Clinical Suspicion

Baert¹,

Damme²,

Oyen

et al. 1995

Urol Int

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This case report of a reninoma or juxtaglomerular cell tumor illustrates that careful preoperative radiological investigation and preoperative frozen-section examination does not always lead to a correct diagnosis. The preoperative diagnosis of juxtaglomerular tumors should therefore primarily depend upon clinical suspicion, eventually followed by directed renal vein renin ratio blood sampling. The importance of early preoperative diagnosis and treatment is stressed.

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Renin Levels in Nephroblastoma (Wilms' Tumour): Report of a Renin Secreting Tumour

Cited by 121 publications

References 22 publications

Renin Levels in the Kangaroo, the Wombat and Other Marsupial Species

Renin Levels in the Kangaroo, the Wombat and Other Marsupial Species

A patient with a juxtaglomerular cell tumor with histological vascular invasion

Juxtaglomerular Cell Tumor: Importance of Clinical Suspicion

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