Repair of articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh

Cui, Lei; Wu, Yalong; Chen, Lian; Zhou, Heng; Yin, Shuo; Liu, Guangpeng; Liu, Wei; Cao, Yilin

doi:10.1016/j.biomaterials.2009.01.045

Cited by 111 publications

(85 citation statements)

References 35 publications

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“…PGA is an FDA-approved polymer that has long been used in biodegradable sutures. In a pig model study of articular cartilage defect, autologous chondrocytes were seeded and implanted (after two weeks of culture) onto a PGA/PLA scaffold and evaluated after six months [104]. At the 6th-month after the surgery, the cells completely filled the site of the defect with mature cartilage-like tissue.…”

Section: Synthetic Polymersmentioning

confidence: 99%

Application of cell and biomaterial-based tissue engineering methods in the treatment of cartilage, menisci and ligament injuries

Trzeciak

Richter

Suchorska

et al. 2016

International Orthopaedics (SICOT)

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Over 20 years ago it was realized that the traditional methods of the treatment of injuries to joint components: cartilage, menisci and ligaments, did not give satisfactory results and so there is a need of employing novel, more effective therapeutic techniques. Recent advances in molecular biology, biotechnology and polymer science have led to both the experimental and clinical application of various cell types, adapting their culture conditions in order to ensure a directed differentiation of the cells into a desired cell type, and employing non-toxic and non-immunogenic biomaterial in the treatment of knee joint injuries. In the present review the current state of knowledge regarding novel cell sources, in vitro conditions of cell culture and major important biomaterials, both natural and synthetic, used in cartilage, meniscus and ligament repair by tissue engineering techniques are described, and the assets and drawbacks of their clinical application are critically evaluated.

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Section: Synthetic Polymersmentioning

confidence: 99%

Application of cell and biomaterial-based tissue engineering methods in the treatment of cartilage, menisci and ligament injuries

Trzeciak

Richter

Suchorska

et al. 2016

International Orthopaedics (SICOT)

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“…Synthetic platforms provide locations for ASCs to adhere, thereby providing an environment conducive for growth and proliferation. Additionally, scaffolds have also been shown to promote differentiation and enable cells to achieve a cartilage-like morphology and express chondro-specific molecules, such as COL2A1 and CSPCP [43].…”

Section: Ascs In Synthetic Scaffolds For Cartilaginous Regenerationmentioning

confidence: 99%

“…Degradation times of approximately 2 months in vivo appeared to match the natural mechanisms of new cartilage formation. Thus, PGA/PLA in combination with ASCs may also serve as a synthetic scaffold for cartilage regeneration [43].…”

Section: Ascs In Synthetic Scaffolds For Cartilaginous Regenerationmentioning

confidence: 99%

Strategies for Bioengineered Scaffolds that Support Adipose Stem Cells in Regenerative Therapies

et al. 2016

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Regenerative medicine possesses the potential to ameliorate damage to tissue that results from a vast range of conditions, including traumatic injury, tumor resection and inherited tissue defects. Adult stem cells, while more limited in their potential than pluripotent stem cells, are still capable of differentiating into numerous lineages and provide feasible allogeneic and autologous treatment options for many conditions. Adipose stem cells are one of the most abundant types of stem cell in the adult human. Here, we review recent advances in the development of synthetic scaffolding systems used in concert with adipose stem cells and assess their potential use for clinical applications.

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“…The optimal scaffold used for engineering a cartilage construct with accurate designed shapes should possess at least three characteristics: good biocompatibility for cartilage formation, ease of being processed into a specific shape, and sufficient mechanical strength for retaining the pre-designed shape during chondrogenesis. Polyglycolic acid (PGA) has proven to be one of the most successful scaffolds for cartilage regeneration (Cui et al, 2009;Frenkel, Di, 2004;Heath, Magari, 1996). Cartilage engineered with the PGA scaffold has structure and composition similar to the native tissue, as demonstrated by histological analysis and cartilage specific matrices (Aufderheide, Athanasiou, 2005;Moran et al, 2003;Yan et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Tissue Engineering for Tissue and Organ Regeneration

Eberli¹

2011

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Repair of articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh

Cited by 111 publications

References 35 publications

Application of cell and biomaterial-based tissue engineering methods in the treatment of cartilage, menisci and ligament injuries

Application of cell and biomaterial-based tissue engineering methods in the treatment of cartilage, menisci and ligament injuries

Strategies for Bioengineered Scaffolds that Support Adipose Stem Cells in Regenerative Therapies

Tissue Engineering for Tissue and Organ Regeneration

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