Repair of Bone in the Presence of Aseptic Necrosis Resulting From Fractures, Transplantations, and Vascular Obstruction

Phemister, Dallas B.

doi:10.2106/00004623-200503000-00029

Cited by 39 publications

(20 citation statements)

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“…By creeping substitution process, the old dead bone is gradually absorbed and replaced by new bone 7. The amount of new bone formed depends largely on the extent of living bone with which dead bone is in contact.…”

Section: Discussionmentioning

confidence: 99%

Open segmental fracture of both bone forearm and dislocation of ipsilateral elbow with extruded middle segment radius

Kumar

Manjhi

Rajak

2013

IJOO

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Extruded middle segment of radius with open segmental fracture both bone forearm and dislocation of ipsilateral elbow is a rare injury. A 12-year-old child presented to us within 4 hours following fall from tree. The child's mother was carrying a 12-cm-long extruded soiled segment of radius. The extruded bone was thoroughly washed. The medullary cavity was properly syringed with antiseptic solution. The bone was autoclaved and put in the muscle plane of the distal forearm after debridement of the wound. After 5 days, a 2.5-mm K-wire was introduced by retrograde method into the proximal radius by passing through the extruded segment. Another 2.5-mm K-wire was passed in ulna. The limb was evaluated clinicoradiologically every 2 weeks. The wound was healed by primary intention. At 4 months, the reposed bone appeared less dense radiologically and K-wire seemed to be out of the bone. In the subsequent months, the roentgenograms show remodeling of the extruded fragment. After 20 weeks, the K-wires were removed (first ulnar and then radial). Complete union was achieved with full range of movement except loss of few degrees of extension of elbow and thumb. This case is reported to show a good outcome following successful incorporation of an extruded segment of radius in an open fracture.

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Section: Discussionmentioning

confidence: 99%

Open segmental fracture of both bone forearm and dislocation of ipsilateral elbow with extruded middle segment radius

Kumar

Manjhi

Rajak

2013

IJOO

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“…This contrasted markedly with patients with four part fractures, in whom six out of eight patients (75%) developed osteonecrosis and the remaining two developed either malunion or degenerative arthritis. Whilst Leyshon [9] has published one of the highest reported rates of osteonecrosis for this particular group, it is important to state that the lower rates reported in other papers are following internal fixation which may obviate osteonecrosis by means of creeping substitution [10].…”

Section: Non-modifiablementioning

confidence: 97%

Post-traumatic osteonecrosis of the proximal humerus

Patel

Colaco

Elvey

et al. 2015

Injury

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“…Phemister was the first to propose that the “aseptic necrosis” might result from fractures, bone graft transplantation, radiation and vascular obstruction from thrombosis, or embolization [85]. ON was later regarded as a primitive vascular problem.…”

Section: Historical Views On the Pathogenesis Of Osteonecrosismentioning

confidence: 99%

The Pathogenesis of Nontraumatic Osteonecrosis

et al. 2012

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Nontraumatic osteonecrosis continues to be a challenging problem causing debilitating major joint diseases. The etiology is multifactorial, but steroid- and alcohol-induced osteonecrosis contribute to more than two thirds of all cases with genetic risk factors playing an important role in many other cases, especially when they contribute to hypercoagulable states. While the exact mechanisms remain elusive, many new insights have emerged from research in the last decade that have given us a clearer picture of the pathogenesis of nontraumatic osteonecrosis of the femoral head. Progression to end stage osteonecrosis of the femoral head appears to be related to four main factors: interactions involving the differentiation pathway of osteoprogenitor cells that promote adipogenesis, decreased angiogenesis, direct suppression of osteogenic gene expression and proliferation of bone marrow stem cells, and genetic anomalies or other diseases that promote hypercoagulable states.

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Repair of Bone in the Presence of Aseptic Necrosis Resulting From Fractures, Transplantations, and Vascular Obstruction

Cited by 39 publications

References 0 publications

Open segmental fracture of both bone forearm and dislocation of ipsilateral elbow with extruded middle segment radius

Open segmental fracture of both bone forearm and dislocation of ipsilateral elbow with extruded middle segment radius

Post-traumatic osteonecrosis of the proximal humerus

The Pathogenesis of Nontraumatic Osteonecrosis

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