Repeated and continuous exposure of laboratory animals to acrolein

Lyon, Juliana Pereira; Jenkins, Lawrence J.; Jones, Robert A.; Coon, R.A.; Siegel, Jamie E.

doi:10.1016/0041-008x(70)90047-5

Cited by 57 publications

(49 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pulmonary responses were not seen in our study; however, lung injury can occur following acrolein exposure. For example, Lyon et al (1970) reported that dogs and guinea pigs continuously (23 hr/day) exposed to 1.0 or 1.8 ppm acrolein for 90 days developed pulmonary emphysema or pulmonary inflammation, respectively. Costa and coworkers (1986) reported that subchronic exposure of F-344 rats to 4 ppm acrolein resulted in focal peribronchial fibrotic lesions and changes in pulmonary function indicative of obstructive airway disease.…”

Section: Notementioning

confidence: 98%

Respiratory Tract Responses in Male Rats Following Subchronic Acrolein Inhalation

Dorman

Struve

Wong

et al. 2008

Inhalation Toxicology

View full text Add to dashboard Cite

The goal of this study was to characterize the respiratory tract toxicity of acrolein, including nasal and pulmonary effects, in adult male F344 rats. Animals underwent whole-body exposure to 0, 0.02, 0.06, 0.2, 0.6, or 1.8 ppm acrolein for 6 hr/day, five days/week for up to 65 exposure days (13 exposure weeks). Respiratory tract histopathology was evaluated after 4, 14, 30, and 65 exposure days, as well as 60 days after the end of the 13 week exposure. Acrolein exposure was associated with reduced body weight gain. Rats exposed to ≥0.06 ppm acrolein had depressed terminal body weights when compared with air-exposed controls. Histologic evaluation of the nasal cavity showed olfactory epithelial inflammation and olfactory neuronal loss (ONL) following exposure to 1.8 ppm acrolein. Moderately severe ONL in the dorsal meatus and ethmoid turbinates occurred within four days while septal involvement developed with ongoing exposure. A rostral-caudal gradient in lesion severity was noted, with the anterior portion of the nasal cavity being more severely affected. Acrolein exposure was associated with inflammation, hyperplasia, and squamous metaplasia of the respiratory epithelium. The lateral wall was amongst the most sensitive locations for these responses and increased respiratory epithelial cell proliferation occurred at this site following 4 to 30 days of exposure to ≥0.6 ppm acrolein. The NOAEL for nasal pathology seen in this study was 0.2 ppm acrolein.

show abstract

Section: Notementioning

confidence: 98%

Respiratory Tract Responses in Male Rats Following Subchronic Acrolein Inhalation

Dorman

Struve

Wong

et al. 2008

Inhalation Toxicology

View full text Add to dashboard Cite

show abstract

“…Acrolein is an unsaturated aliphatic aldehyde with toxic and sensory irritating effects (15)(16)(17)(18)(19). It is a component of cigarette smoke (20), engine exhausts (21), and industrial by-products (22).…”

Section: Introductionmentioning

confidence: 99%

Acrolein Depletes the Neuropeptides CGRP and Substance P in Sensory Nerves in Rat Respiratory Tract

Springall¹,

Edginton²,

Price³

et al. 1990

Environmental Health Perspectives

View full text Add to dashboard Cite

The mammalian respiratory tract is densely innervated by autonomic and sensory nerves around airways and blood vessels. Subsets of these nerves contain a number of putative neurotransmitter peptides, such as substance P and calcitonin gene-related peptide (CGRP) in sensory nerves and vasoactive intestinal polypeptide (VIP), possibly serving autonomic functions. CGRP is also found in endocrine cells in rat airway epithelium. These peptides are all pharmacologically potent effectors of bronchial and vascular smooth muscle and bronchial secretion. Their functions in vivo are less well established. We have therefore examined the effects of inhaled acrolein, a sensory irritant, on three pulmonary neuropeptides: CGRP, substance P, and VIEP. Groups of rats (n = 3 each) were exposed for 10 min to acrolein in air (Ct = 510, 1858, and 5693 mg.min/m3) or to air alone. Fifteen minutes later they were killed (pentabarbitone IP) and their respiratory tracts were dissected and fixed in 0.4 % p-benzoquinone solution. Cryostat sections were stained by indirect immunofluorescence for a general nerve marker (PGP 9.5) and neuropeptides. The acrolein-treated animals had a dose-related decrease in tracheal substance P-and CGRP-immunoreactive nerve fibers compared with controls. No change was seen in total nerve flber distribution and number (PGP 9.5) or VIP immunoreactivity, nor in CGRP-immunoreactive epithelial endocrine cells. It is concluded that the rat tracheal peptidergic nerves are a sensitive indicator of inhaled irritant substances. Their reduced immunoreactivity may be because of a release of sensory neuropeptides that could play a role in the physiological response to irritant or toxic compounds.

show abstract

“…Also, the RD 50 values for various strains of rat exposed to acrolein range from 1.06 to 2.90 ppm (Nielsen et al, 1984;Steinhagen and Barrow, 1984;IPCS, 1992). Additionally, rats that were exposed subchronically to acrolein vapor at atmospheric concentrations of ≥1.4 ppm had eye irritation and decreases in both food consumption and body weight gain (Lyon et al, 1970;Feron et al, 1978). Overall, the results from the developmental toxicology study suggest that 9.87 ppm is the threshold for maternal toxicity due to 3-MTP vapor exposure, and is close to the a no-observed-adverse-effect level (NOAEL).…”

Section: Discussionmentioning

confidence: 97%

Developmental toxicity study with 3-(methylthio)propionaldehyde vapor by whole-body exposure of Sprague-Dawley rats

Ballantyne¹,

Schroeder²

2005

J. Appl. Toxicol.

View full text Add to dashboard Cite

Time-mated Sprague-Dawley rats were exposed whole body to analytically measured 3-(methylthio) propionaldehyde (3-MTP) vapor concentrations of 0 (air controls), 9.87, 58.3 and 127.8 ppm over gestational days (gd) 6-15 for 6 h day(-1). There was an exposure concentration-related maternal toxicity (clinical signs, body weight change and food consumption) that was marginal at 9.87 ppm. No effects on gestational parameters, fetal numbers and sex ratio or fetal body weights were noted. There was no increase in the incidence of either malformations or variations (total, external, visceral or skeletal). Thus, the no-observed-adverse-effect level (NOAEL) for development toxicity for exposure to 3-MTP vapor was 127.8 ppm.

show abstract

Repeated and continuous exposure of laboratory animals to acrolein

Cited by 57 publications

References 6 publications

Respiratory Tract Responses in Male Rats Following Subchronic Acrolein Inhalation

Respiratory Tract Responses in Male Rats Following Subchronic Acrolein Inhalation

Acrolein Depletes the Neuropeptides CGRP and Substance P in Sensory Nerves in Rat Respiratory Tract

Developmental toxicity study with 3-(methylthio)propionaldehyde vapor by whole-body exposure of Sprague-Dawley rats

Contact Info

Product

Resources

About