Repeated Hepatic Resection versus Radiofrequency Ablation for Recurrent Hepatocellular Carcinoma after Hepatic Resection: A Propensity Score Matching Study

Song, Kyoung Doo; Lim, Hyo Keun; Rhim, Hyunchul; Lee, Min Woo; Kim, Young-Sun; Lee, Won Jae; Paik, Yong Han; Gwak, Geum‐Youn; Kim, Jong Man; Kwon, Choon Hyuck David; Joh, Jae‐Won

doi:10.1148/radiol.14141568

Cited by 87 publications

(106 citation statements)

References 25 publications

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“…2). A 20 percent standardized difference between two groups indicates a small difference21, and a 10 percent standardized difference might correspond to the smallest potentially meaningful difference23. Our propensity score model was discriminated effectively and well calibrated between patients who underwent RFA and OT at baseline.…”

Section: Discussionmentioning

confidence: 85%

“…The propensity score presents the conditional probability of receiving an exposure given a vector of the measured covariates21. In our study, propensity scores for all the patients were estimated by multiple logistic-regression models using the following baseline characteristics as covariates: sex, age, nodule volume, ethnic group, SF-36 dimension scores (PF, RP, BP, GH, VT, SF, RE, MH), smoke, drink, chronic diseases, marital status, monthly income, education lever and current job22.…”

Section: Discussionmentioning

confidence: 99%

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Quality of Life and Cost-Effectiveness of Radiofrequency Ablation versus Open Surgery for Benign Thyroid Nodules: a retrospective cohort study

Yue

Wang

et al. 2016

Sci Rep

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This study is to compare the health-related quality of life (HRQoL) and cost-effectiveness of radiofrequency ablation (RFA) and open thyroidectomy (OT) for benign thyroid nodules (BTNs) treatment. HRQoL and utility were assessed for 404 BTN patients immediately before treatments (RFA:OT = 137:267) and at 6-month visit. A cost-effectiveness analysis was performed from societal perspective in the China context. Resource use (hospitalization, sick leaves) was collected. We used the net monetary benefit approach and computed cost-effectiveness acceptability curves for RFA and OT. Sensitivity analyses of costs of RFA were performed. At 6-month visit, patients treated with RFA had significantly better HRQoL than patients treated with OT on general health (68.5 versus 66.7, P = 0.029), vitality (71.3 versus 67.5, P < 0.001) and mental health (80.9 versus 79.3, P = 0.038). RFA was more effective than OT in terms of quality-adjusted life-years (QALYs; 0.01QALY/patient) but more expensive (US$823/patient). The probability that RFA would be cost effective at a US$50,000/QALY threshold was 15.5% in China, and it would be increased to 88.4% when price of the RFA device was lowered by 30%. RFA exhibited a significant improvement of HRQoL relative to OT, but is unlikely to be cost effective at its current price in short time.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Quality of Life and Cost-Effectiveness of Radiofrequency Ablation versus Open Surgery for Benign Thyroid Nodules: a retrospective cohort study

Yue

Wang

et al. 2016

Sci Rep

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“…Some studies offered multiple treatment modalities but chose to report only a given treatment subgroup; four studies looked at RH alone. Centres offering ablation reported mostly RFA only; however, three studies used both RFA and ethanol ablation, combining these into a single ablation group. Additional ablation techniques, such as holminum and microwave coagulation, were reported in single studies.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of determinants of survival following treatment of recurrent hepatocellular carcinoma

Erridge

Pucher

Markar

et al. 2017

British Journal of Surgery

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“…However, Song KD et al [22] described that RFA and repeated hepatectomy attained similar survival benefits in the management of recurrent HCC after hepatectomy. They compared the long-term outcomes of repeated hepatic resection and RFA for recurrent HCC by using propensity score matching.…”

Section: P Valuementioning

confidence: 99%

“…However, the repeated hepatectomy would be technically more difficult, because of intra-abdominal adhesions caused by previous hepatic resections as well as new growth of intrahepatic vascular structures after previous hepatic resection, and there is a potential risk of postoperative hepatic failure after repeated hepatic resection in patients with limited hepatic function reserve [22]. On the other hand, RFA can be repeatedly performed for local recurrence after both RFA and new HCC appeared in the remaining liver.…”

Section: P Valuementioning

confidence: 99%

Effectiveness of Radiofrequency Ablation of Initial Recurrent Hepatocellular Carcinoma after Hepatectomy: Long-Term Results and Prognostic Factors

Shinozuka¹,

Shibata²,

Imamine³

et al. 2017

OJRad

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Background: Intrahepatic recurrence of hepatocellular carcinoma (HCC) is frequently noted in patients after hepatectomy of HCC. Recurrence HCC is usually diagnosed as small nodule ≤ 2 cm in diameter due to the frequent postoperative check up with US, dynamic CT, or dynamic EOB-MRI. Radiofrequency ablation (RFA) is recommended for these small HCCs, because RFA is minimally invasive, effective, and repeatedly performed. Purpose: To investigate the long-term outcome and prognostic factors of RFA in recurrent HCC after heaptectomy. Material and Methods: Between February 2002 and October 2011, 75 patients with initial intrahepatic recurrence of HCC after hepatectomy underwent RFA. The 57 patients were men and 18 women, whose age ranged from 44 years to 83 years (median, 69 years). Sixty-nine patients had a single nodule and 6 patients had two nodules. The size of the 81 nodules ranged 5 -30 mm (median, 15 mm). Regular follow-up after RFA was performed to evaluate rates of local tumor progression, overall survival rates, and disease-free survival rates. Prognostic factors related to overall survivals and disease-free survivals were evaluated, too. Results: During follow-up periods after RFA (3 to 151 months, median, 55 months), local recurrence was noted in 10 nodules of 10 patients (10/81 nodules = 12.3%). The rates of local recurrence of 1-yr, 3-yr, 5-yr, and 8-yr were 7.6%, 12.0%, 12.0%, and 12.0%, respectively. During the follow-up periods, 36 patients were alive and 39 died. The cumulative overall survival rates of 1-yr, 3-yr, 5-yr, and 10-yr were 97.3%, 79.1%, 56.6%, and 32.2%, respectively. The cumulative disease-free survival rates of 1-yr, 3-yr, and 5-yr were 42.7%, 18.8%, and 12.6%, respectively.

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Repeated Hepatic Resection versus Radiofrequency Ablation for Recurrent Hepatocellular Carcinoma after Hepatic Resection: A Propensity Score Matching Study

Abstract: The long-term OS and DFS were not significantly different between repeated hepatic resection and RF ablation for patients with recurrent HCC after hepatic resection.

Cited by 87 publications

References 25 publications

Quality of Life and Cost-Effectiveness of Radiofrequency Ablation versus Open Surgery for Benign Thyroid Nodules: a retrospective cohort study

Quality of Life and Cost-Effectiveness of Radiofrequency Ablation versus Open Surgery for Benign Thyroid Nodules: a retrospective cohort study

Meta-analysis of determinants of survival following treatment of recurrent hepatocellular carcinoma

Effectiveness of Radiofrequency Ablation of Initial Recurrent Hepatocellular Carcinoma after Hepatectomy: Long-Term Results and Prognostic Factors

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