Repetitive transcranial magnetic stimulation in veterans with debilitating tinnitus: A pilot study

Lee, Scott L.; Abraham, BS Megan; Cacace, Anthony T.; Silver, Steven M.

doi:10.1016/j.otohns.2007.11.035

Cited by 24 publications

(9 citation statements)

References 4 publications

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“…There are 3 mainstream methods of evaluating the outcome of tinnitus therapy: (1) questionnaires, such as TQ and THI, (2) self-rating of tinnitus, for example, 10-grading or 100-grading visual analogue scores (VAS), and (3) audiometric examinations, for instance, tinnitus frequency-and loudness-matching or residual inhibition measures [Kleinjung et al, 2005[Kleinjung et al, , 2008Lee et al, 2008;Mennemeier et al, 2008;Henkin et al, 2011]. Because measurements based on these methods are variable, and because each method contains its own inherent biases, we felt it was particularly important and useful to employ a multidirectional assessment.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Theta-Burst Repetitive Transcranial Magnetic Stimulation for Treating Chronic Tinnitus

Chung¹,

Tsai²,

Lin³

et al. 2011

Audiol Neurotol

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Objectives: Repetitive transcranial magnetic stimulation (rTMS), a noninvasive method for altering cortical excitability, is becoming a therapeutic strategy in auditory research institutions worldwide. Application of inhibiting rTMS on these overactive cortical regions can result in effective tinnitus suppression. The aim of this study is to investigate the efficacy of theta-burst rTMS in patients with chronic tinnitus. Study Design: Parallel randomized control study. Setting: Tertiary referral center. Patients: We enrolled 2 female and 20 male patients in this study. The evaluative tools included tinnitus frequency- and loudness-matching, tinnitus questionnaires (TQ), and the Tinnitus Handicap Inventory (THI). Methods: The orthogonal projection of the auditory cortex on the scalp was focalized. A figure-eight coil was placed on the surface of the skull over the targeted region with the intensity setting at 80% of the resting motor threshold. We delivered 900 pulses of theta-burst rTMS daily for 10 business days. Main Outcome Measures: Nine of twelve patients (75%) in the active-stimulation group reported tinnitus suppression following treatment with rTMS. The treatment led to reductions of 8.58 and 8.33 in the mean TQ global and THI scores, respectively. Tinnitus loudness also decreased significantly after delivering rTMS. Results: Descriptive analysis of the TQs revealed that patients experienced significant improvements in emotional distress levels and somatic symptoms. Conclusions: Our preliminary results demonstrate that theta-burst rTMS treatments offer a method of modulating tinnitus. Patients could benefit from emotional improvements, even more than auditory perceptive relief. Further studies are needed to establish a standard protocol and to clarify nervous propagation along the auditory and psychological projection following treatment with rTMS.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Theta-Burst Repetitive Transcranial Magnetic Stimulation for Treating Chronic Tinnitus

Chung¹,

Tsai²,

Lin³

et al. 2011

Audiol Neurotol

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“…Effects are less often measured on the Tinnitus Handicap Inventory (THI) or by global assessment measures. Average improvement in 2 cohort series on the THI was 4 points (23 patients) [Lee et al, 2008;Ting et al, 2011]. One case series includes a visual analogue scale (VAS) on annoyance reporting an 18-point improvement on a scale of 0-100 in 16 patients [Minami et al, 2011].…”

Section: Introductionmentioning

confidence: 99%

Bilateral Low-Frequency Repetitive Transcranial Magnetic Stimulation of the Auditory Cortex in Tinnitus Patients Is Not Effective: A Randomised Controlled Trial

et al. 2013

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Background: Although some therapies may be beneficial for some patients in reducing tinnitus, there is no curative therapy. Repetitive transcranial magnetic stimulation (rTMS) has been applied as a treatment for chronic tinnitus, but the effect remains controversial. Material and Methods: Fifty patients were treated with rTMS or placebo. Treatment consisted of 2,000 TMS pulses on each auditory cortex, at a rate of 1 Hz and an intensity of 110% of the individual motor threshold, on 5 consecutive days. rTMS and placebo effects were evaluated directly after treatment, after 1 week, and after 1, 3 and 6 months. Primary outcome was the Tinnitus Questionnaire (TQ). Secondary outcomes were the Tinnitus Handicap Inventory (THI) and a visual analogue scale. Results: At none of the follow-up evaluation moments a significant difference between rTMS and placebo was observed with respect to changes in TQ or THI scores relative to pretreatment scores. Multilevel modelling (MLM) analyses did not show a global treatment effect either. Patients with a higher degree of burden showed slightly greater improvement after rTMS (only significant on the THI with MLM analyses). Conclusion: Bilateral low-frequency rTMS of the auditory cortex was not effective in treating tinnitus.

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“…The results of some studies suggest that rTMS might be a useful treatment for tinnitus (Kleinjung et al, 2008;Khedr et al, 2008;Lopez-Ibor et al, 2008). Lee et al, 2008 did not report statistically significant improvements. In spite of the many advances in medical science, progress in treatment of tinnitus has been tardy.…”

Section: Transcranial Magnetic Stimulationmentioning

confidence: 94%

Bhramari Pranayama and Alternative Treatments of Tinnitus: In Pursuit of the Cure

Pandey¹

2011

Up to Date on Tinnitus

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Repetitive transcranial magnetic stimulation in veterans with debilitating tinnitus: A pilot study

Abstract: The parameters for this rTMS study are different from those that reported success with its use. With these current parameters, rTMS did not improve tinnitus in veterans. There were no permanent adverse outcomes.

Cited by 24 publications

References 4 publications

Effectiveness of Theta-Burst Repetitive Transcranial Magnetic Stimulation for Treating Chronic Tinnitus

Effectiveness of Theta-Burst Repetitive Transcranial Magnetic Stimulation for Treating Chronic Tinnitus

Bilateral Low-Frequency Repetitive Transcranial Magnetic Stimulation of the Auditory Cortex in Tinnitus Patients Is Not Effective: A Randomised Controlled Trial

Bhramari Pranayama and Alternative Treatments of Tinnitus: In Pursuit of the Cure

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