Report of a Case of Central and Peripheral Neurofibromatosis

Bassoe, Peter; Nuzum, Frank

doi:10.1097/00005053-191512000-00001

Cited by 67 publications

(26 citation statements)

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“…MA is a rare, focal intracranial lesion that was first described by Bassoe and Nuzum in 1915 as an incidental autopsy finding in a patient with neurofibromatosis-2 (NF2) [81]. Takeshima et al demonstrated that only 25 % of MA cases were associated with NF2, while in the remaining 75 %, it occurred sporadically [72].…”

Section: Discussionmentioning

confidence: 99%

Sporadic meningioangiomatosis with and without meningioma: analysis of clinical differences and risk factors for poor seizure outcomes

Zhang

Wang²,

Wang

et al. 2015

Acta Neurochir

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Clinical differences may be caused by the different biological natures. MA-M seems to be a neoplastic lesion, while pure MA seems to be a non-neoplastic lesion. Long-term follow-up is required for MA-M. Because the coexistence of hippocampal sclerosis may explain the poor seizure outcomes of MA located in the temporal lobe, it is important to identify underlying hippocampal sclerosis and to perform complete resection.

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Section: Discussionmentioning

confidence: 99%

Sporadic meningioangiomatosis with and without meningioma: analysis of clinical differences and risk factors for poor seizure outcomes

Zhang

Wang²,

Wang

et al. 2015

Acta Neurochir

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“…The differential diagnosis on imaging includes meningioma, oligodendroglioma, granulomatous meningitis, parasitic diseases, and calcified vascular malformation (1,5,10,17,22,23). Although the majority of cases of meningioangiomatosis are sporadic, particular note should be made of the association between meningioangiomatosis and NF2.…”

Section: Discussionmentioning

confidence: 99%

Multifocal meningioangiomatosis in a 3-year-old patient

Jamil¹,

Ramkissoon

Folkerth

et al. 2012

PED

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Meningioangiomatosis consists of benign hamartomatous lesions of the brain and the leptomeninges, which typically present with seizure. Management is predicated on resection and control of seizures with medication. Lesions are typically solitary. Multifocal meningioangiomatosis is extremely rare, with only 2 cases reported in adults and none in children. The authors report the first case, to their knowledge, of multifocal meningioangiomatosis in a child. This unique case highlights therapeutic challenges associated with these lesions and demonstrates that multifocality is possible in the pediatric population. This finding has implications for diagnosis and follow-up for children afflicted with these tumors.

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“…The most important differential diagnosis of meningioma with MA is because the prognosis and evolution of these 2 entities is entirely different 24 . Moreover, the MA can simulate an invasive meningioma because infiltration of the cortex by the proliferating of vascular cells, especially if associated with marked cellularity and reactive gliosis, may be erroneously interpreted as tumor invasion by those who are not familiar with this condition 1,29 . Traditionally, determination of malignant meningioma is based on features such as brain invasion and/or histological anaplasia 3 .…”

Section: Differential Diagnosismentioning

confidence: 99%

“…Meningioangiomatosis (MA) was first described by Bassoe and Nuzum in 1915 as an incidental autopsy finding in a 15-year-old boy with NF2…”

Section: Introductionmentioning

confidence: 99%

Meningioangiomatosis: clinical-radiological features and surgical outcome

et al. 2010

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SummaryMeningioangiomatosis (MA) is a rare, benign neoplastic disorder involving the cortex and leptomeninges, the sporadic form, commonly presents as refractory localization-related epilepsy, but could be asymptomatic especially in older patients. The imaging features may be entirely non-specific. Magnetic Resonance Imaging (MRI) erroneously suggests meningioma, lowgrade tumour or vascular malformations.The pathological findings are characterised by proliferation of meningothelial cells and leptomeningeal vessels and calcifications within the mass. Macroscopically there is dense thickening in the underlying cortex, often in a sharply defined area.In this article we report 3 cases of MA, neither of whom had a familiary history or stigmata of Neurofibromatosis (NF). We discuss and place particular emphasis on the clinical presentation and diagnosis imaging, as well as on the outcome. We also review the literature concerning about the aetiology, pathology findings and imaging features of MA.KEY WORDS: Brain tumor. Histopathology. Meningioangiomatosis. Magnetic resonance imaging. Seizure. Meningioangiomatosis: características clínico-radioló-gicas y resultados quirúrgicos ResumenLa meningioangiomatosis (MA) es un proceso neoplásico benigno raro, que envuelve el córtex y leptomeninges, en su forma esporádica comúnmente se presenta con epilepsia refractaria, en relación a su localización, pero puede ser asintomática, especialmente en adultos mayores. Las características de imagen pueden ser totalmente inespecíficas. Las imágenes de resonancia magnética erróneamente sugieren la presencia de un meningioma, tumores de bajo grado, o malformaciones vasculares.Los hallazgos patológicos se caracterizan por la proliferación de células meningoteliales, vasos leptomeningeos y calcificaciones dentro del tumor. Macroscópicamente se observa un denso engrosamiento en el córtex adyacente, generalmente con un área claramente definida.En este articulo, se describen 3 casos de MA, ninguno de ellos presentaba historia familiar o estigmas de neurofibromatosis (NF). Nosotros realizamos la discusión, haciendo particular énfasis en la presentación clínica y diagnóstico por imágenes, así como en el pronóstico.

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Report of a Case of Central and Peripheral Neurofibromatosis

Cited by 67 publications

References 0 publications

Sporadic meningioangiomatosis with and without meningioma: analysis of clinical differences and risk factors for poor seizure outcomes

Sporadic meningioangiomatosis with and without meningioma: analysis of clinical differences and risk factors for poor seizure outcomes

Multifocal meningioangiomatosis in a 3-year-old patient

Meningioangiomatosis: clinical-radiological features and surgical outcome

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