The Sahel region is considered a hotspot for climate change hazards and vulnerability of weather reliant sectors, including agriculture. Farmers in Burkina Faso have a long history of adapting their farming activities to frequent changes in climate. Using 150 in-person surveys, this study assesses farmers’ perceptions of climate change based on multiple climate variables, and reviews adaptation practices, including soil and water conservation strategies, in the Soudanian, Soudano-Sahelian, and Sahelian agroclimatic zones of Burkina Faso. In general, farmers are aware of changing climatic conditions, including increased temperatures, greater rainfall variability, heavier precipitation events, delayed onset, and premature offset of the rainy season. However, farmers perceive shifts in climate differently depending on their location and agroclimatic zone. As a result, different adaption strategies are implemented by farmers according to the climatic, societal, and economic context. Survey results show that in the Sahel, climate adaptation strategies rely on traditional knowledge and experimental approaches; whereas in the Soudanian zone, where weather conditions are more favorable for agriculture, adaptation practices are market oriented. These regional differences are important for targeting advisory services, planning processes, and decision-making to support the effective provision of weather and climate information services to the last mile.