Repression von alkoholdehydrogenase, malatdehydrogenase, isocitratlyase und malatsynthase in hefe durch glucose

Witt, I.; Kronau, Rainer; Holzer, Helmut

doi:10.1016/s0926-6593(66)80094-2

Cited by 194 publications

(69 citation statements)

References 18 publications

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“…It is accompanied by a variety of individual biochemical control processes, including the repression of several tricarboxylic acid cycle enzymes, alterations in the content of components of the electron transport uain, repression of the enzymes of the gluconeogenetic pathway, and even a proteolytic inactivation of some repressible (iso-) enzymes Witt et al, 1966;Beck & von Meyenburg, 1968;Haarasilta & Oura, 1975;Holzer, 1976;Fiechter et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

The Role Of Limited Respiration In The Incomplete Oxidation Of Glucose By Saccharomyces Cerevisiae

Rieger¹,

Käppeli²,

Fiechter³

1983

Microbiology

121

145

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\The respiratory capacity of Saccharomyces cerevisiae growing in continuous culture on glucose and on mixtures of glucose and ethanol was investigated. An oxygen uptake rate of 8 mmol g-l h-l was found to limit the ability of the organism to degrade a substrate purely oxidatively. On glucose as sole energy and carbon source, this respiration rate was invariably achieved at an identical growth rate and thus at an identical substrate uptake rate when the inlet glucose concentration was varied. The rate of ethanol co-consumption together with glucose was strictly governed by this limiting maximum respiratory capacity and no repression of respiration was observed at dilution rates where ethanol was excreted by the cells. Hence, a limitation in some step in the oxidative branch of catabolism is likely to be responsible for incomplete oxidation of glucose at high growth rates rather than an undefined action of glucose repression.

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Section: Introductionmentioning

confidence: 99%

The Role Of Limited Respiration In The Incomplete Oxidation Of Glucose By Saccharomyces Cerevisiae

Rieger¹,

Käppeli²,

Fiechter³

1983

Microbiology

121

145

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“…Many early workers examined the nature of the sugar source and its effect on the control of respiration Witt et al, 1966;Hommes, 1966;Gorts, 1967). However, it would now be generally recognized that the energy flux generated by the carbon source, and not simply the presence of the substrate per se, is the primary cause of repression (Beck & von Meyenburg, 1968;von Meyenburg, 1969;Suomalainen et al, 1973 ;Bijkerk & Hall, 1977;Barford, 1979).…”

Section: Introductionmentioning

confidence: 99%

“…These include the repression of the tricarboxylic acid cycle enzymes and electron transport chain components as well as structural changes to the mitochondria (Strittmatter, 1957;Witt et al, 1966;Beck & von Meyenburg, 1968;Chapman & Bartley, 1968;Gorts, 1971 ;Ferdouse et al, 1972;Haarasilta & Oura, 1975). Cyclic AMP levels have been shown to correlate approximately with the level of respiratory repression and gene-cyclic AMP interactions have been described (Fang & Butow, 1970;Van Wijk & Konijn, 1971).…”

Section: Introductionmentioning

confidence: 99%

An Examination of the Crabtree Effect in Saccharomyces cerevisiae: the Role of Respiratory Adaptation

Barford¹,

Hall²

1979

Journal of General Microbiology

119

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The control of glycolysis and respiration in a strain of baker's yeast was quantified, including, for the first time, corrections obtained from carbon and redox balances which allowed for interactions between anabolism and catabolism. When these corrections were applied, no repression of respiration was observed during fully adapted growth in continuous culture ; however, the rate of respiration reached a maximum value, independent of the nature of the energy substrate, at a specific growth rate less than the maximum specific growth rate of the organism. During batch growth, considerable adaptation was necessary for this organism to achieve its maximum respiratory capacity. Further, this adaptation was extremely slow, particularly when glucose or maltose was the limiting substrate, and its full extent was frequently not achieved. Consequently, a residual repression, presumably originally caused by growth under restricted aeration in shake flasks, was observed during batch growth.

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“…It is possible that this putative cis element has been conserved through evolution and represents part of a common mechanism of gene regulation. The genes encoding MS and ICL are regulated by carbon catabolite repression in Saccharomyces cerevisiae (Witt et al, 1966) therefore this is one possible common control mechanism. MS and ICL genomic clones from Brassica napus have been isolated and nucleotide sequence of the transcribed regions published (Comai et al, 1992;Zhang et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Analysis of the cucumber malate synthase gene promoter by transient expression and gel retardation assays

Graham

Baker

Leaver³

1994

The Plant Journal

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Repression von alkoholdehydrogenase, malatdehydrogenase, isocitratlyase und malatsynthase in hefe durch glucose

Cited by 194 publications

References 18 publications

The Role Of Limited Respiration In The Incomplete Oxidation Of Glucose By Saccharomyces Cerevisiae

The Role Of Limited Respiration In The Incomplete Oxidation Of Glucose By Saccharomyces Cerevisiae

An Examination of the Crabtree Effect in Saccharomyces cerevisiae: the Role of Respiratory Adaptation

Analysis of the cucumber malate synthase gene promoter by transient expression and gel retardation assays

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