Reproducibility of HOMA and QUICKI among individuals with variable glucose tolerance

Is skinfold thickness as good as DXA when measuring adiposity contributions to insulin resistance in adolescents?

“…Even though HOMA has been considered to be an appropriate measure of IR in large epidemiologic studies (Wallace and Matthews, 2002), its test-retest reliability in both clinical and epidemiologic studies has been reported to be 0.55-0.66 (Borai et al, 2010;Mather et al, 2001;Sarafidis et al, 2007). Investigators should therefore be aware of this issue regarding the reliability of HOMA in assessing IR since only single serum insulin and glucose measurement was carried out for NHANES data.…”

Selection of the appropriate method for the assessment of insulin resistance

“…Recent studies have indicated that the biological variation of insulin levels and fasting sample-derived indices of IR are greatly influenced by the degree of glucose tolerance and also by IR-modifying medications [ 48 - 50 ]. Owing to biological variation in fasting insulin levels, values for fasting sample-derived indices are more reliable in subjects with normal glucose tolerance than in individuals with type 2 diabetes.…”

Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study

“…These data imply that HOMA-IR cannot be used to diagnose individuals with NAFLD due to the PNPLA3 I148M variant, and that they can only be identified by genotyping for this gene variant [10]. A limitation of HOMA-IR is that it is valid only as long as serum insulin concentrations reflect merely insulin sensitivity, not secretion [40][41][42]. In individuals with non-diabetic glucose tolerance, fasting glucose and insulin concentrations are closely positively correlated [43].…”