Reproductive and developmental toxicities of zinc supplemented rats

Johnson, Frank O.; Gilbreath, Ebony; Ogden, L. J.; Graham, Thomas C.; Gorham, S. L.

doi:10.1016/j.reprotox.2010.10.009

Cited by 14 publications

(8 citation statements)

References 45 publications

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“…Few studies exist that observe Zn 2+ reprotoxicity [173]. ZnCl 2 dietary supplementation to both male and female rats at 30 mg/kg/day but not 15 or 7.5 mg/kg/day showed significant reduction in fertility, offspring viability, and body weight of F1 pups; however, it had no effect on litter size (male reprotoxicity alone was not observed) [174]. Nanosized ZnO toxicity induces sea urchin sperm DNA damage, but it does not reduce fertility [175].…”

Section: Spermatotoxicity and Reprotoxicity Of High Zinc Contaminamentioning

confidence: 99%

Zinc: A Necessary Ion for Mammalian Sperm Fertilization Competency

Kerns

Zigo

Šutovský

2018

IJMS

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The importance of zinc for male fertility only emerged recently, being propelled in part by consumer interest in nutritional supplements containing ionic trace minerals. Here, we review the properties, biological roles and cellular mechanisms that are relevant to zinc function in the male reproductive system, survey available peer-reviewed data on nutritional zinc supplementation for fertility improvement in livestock animals and infertility therapy in men, and discuss the recently discovered signaling pathways involving zinc in sperm maturation and fertilization. Emphasis is on the zinc-interacting sperm proteome and its involvement in the regulation of sperm structure and function, from spermatogenesis and epididymal sperm maturation to sperm interactions with the female reproductive tract, capacitation, fertilization, and embryo development. Merits of dietary zinc supplementation and zinc inclusion into semen processing media are considered with livestock artificial insemination (AI) and human assisted reproductive therapy (ART) in mind. Collectively, the currently available data underline the importance of zinc ions for male fertility, which could be harnessed to improve human reproductive health and reproductive efficiency in agriculturally important livestock species. Further research will advance the field of sperm and fertilization biology, provide new research tools, and ultimately optimize semen processing procedures for human infertility therapy and livestock AI.

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Section: Spermatotoxicity and Reprotoxicity Of High Zinc Contaminamentioning

confidence: 99%

Zinc: A Necessary Ion for Mammalian Sperm Fertilization Competency

Kerns

Zigo

Šutovský

2018

IJMS

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“…Another study has shown mild adverse toxic effects on reproductive endpoints and liver function in adult rats, as well as abnormal developmental effects in offspring when supplemented with Zn at concentrations of 7.5, 15, and 30 mg/kg [22]. However, zinc toxicity in humans is considered rare, but it has been known to occur [23].…”

Section: Discussionmentioning

confidence: 99%

Increased Stem Cell Marker Expressions during the Peri-Implantation Period in the Rat Endometrium: Constructive Role of Exogenous Zinc and/or Progesterone

Şahin¹,

Dilsiz

Demiray

et al. 2014

BioMed Research International

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Background. The aim of this study is to determine the effects of zinc and/or progesterone via the expression of αvβ5 integrins and Vitronectins and embryonic stem cell markers during the peri-implantation period. Methods. Four experimental groups were organized. All subjects were mated with males of the same strain to induce pregnancy; after 5 days, zinc and/or progesterone were administered. Blood levels of zinc and progesterone were determined on the sixth day and endometrial tissues were obtained in order to evaluate the immunohistochemical expression of integrins and embryonic stem cell markers. Results. The αvβ5 integrin and vitronectin expression increased in the zinc group compared with the control group and no difference in the progesterone group and zinc + progesterone group. Expression of Klf-4, Sox-2, and c-Myc was found to be increased in the zinc group compared to controls, while no difference was determined between the progesterone, zinc + progesterone, and control groups. Distinctively, expression of the embryonic stem cell marker Oct-4 was increased in all of the experimental groups. Conclusions. Expression of αvβ5 integrin, vitronectin, and embryonic stem cell markers might be increased by the administration of zinc. Our results suggest that zinc could be useful in the induction of implantation rates.

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“…The rat's placental barrier can be crossed by Zn. Wilson et al (7) reported that when pregnant C57Bl/6 J female mice were fed 10 mg/kg Zn, the amount of Zn absorbed within 24 h by the entire fetus increased as a function of application time of pregnancy (between days [15][16][17][18][19][20][21]. Numerous animal studies on the effects of various Zn compounds on reproduction are available.…”

Section: Zaher Et Almentioning

confidence: 99%

Some Teratogenic Outcomes in Rats Exposed to Zinc Chloride Pre and Post Pregnancy

2021

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The aim of present study was to evaluate the possibility of teratogenicity in rats when exposed to zinc chloride (ZnCl2) pre and post pregnancy. To achieve this goal, a total of 40 mature Albino Wistar female rats were divided equally into four groups as follows: T1, dosed 0.7 mg/day ZnCl2 for two months before mating and till to the day 5th of pregnancy, the females of this group were mated with males dosed 0.7 mg/day ZnCl2 for two weeks before mating; T2, dosed 0.7 mg/day ZnCl2 for two months before mating and till to the day 16th of pregnancy and then were mated with control males (not exposed to any level of ZnCl2); T3, dosed 0.7mg/day ZnCl2 for two months before mating and till the end of pregnancy and were mated with control males; Control, dosed with water free from ZnCl2 along the period of experiment and were mated with control males. At the end of each pregnancy phase, results revealed that alpha fetoprotein serum levels were significantly (P<0.05) higher in all treatment groups compared to the control group, and the most prominent increase was observed in the T3 group. All treatment groups showed a significant (P<0.05) decrease in gestation, viability, and lactation indices when compared to the control group, with the T3 group showing the most significant decrease. Additionally, on days 1, 4, 7, 14, and 21 of lactation period, there was a significant (P<0.05) decrease in mean pup body weights in treated groups compared to the control group, with T3 group having the most prominent body weight decrease. The findings of this study revealed that ZnCl2 at a daily dose of 0.7 mg may cause teratogenic defects in rats at various stages of pregnancy, particularly at the third stage. As high-risk groups, pregnant women and children should use Zn supplementation carefully, whether as a food additive or for self-medication. Simultaneously, evaluating effect of low-dose Zn supplementation over a longer duration is required.

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Reproductive and developmental toxicities of zinc supplemented rats

Cited by 14 publications

References 45 publications

Zinc: A Necessary Ion for Mammalian Sperm Fertilization Competency

Zinc: A Necessary Ion for Mammalian Sperm Fertilization Competency

Increased Stem Cell Marker Expressions during the Peri-Implantation Period in the Rat Endometrium: Constructive Role of Exogenous Zinc and/or Progesterone

Some Teratogenic Outcomes in Rats Exposed to Zinc Chloride Pre and Post Pregnancy

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