Reproductive disease and congenital malformations caused by Menangle virus in pigs

Love, R.J.; Philbey, Adrian; Kirkland, PD; Ross, Anthony; Davis, R J; Morrissey, C. Orla; Daniels, Peter

doi:10.1111/j.1751-0813.2001.tb14578.x

Cited by 30 publications

(59 citation statements)

References 32 publications

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“…2 In a cross-sectional study conducted in August-September 1997, clear age-related serological profiles were demonstrated (Figure 4). A spread of mainly low positive titres was detected in young pigs that had colostrum from immune sows.…”

Section: Cross-sectional Serological Studies Of Menangle Virus Infectmentioning

confidence: 96%

Epidemiology and control of Menangle virus in pigs

et al. 2001

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Serological evidence of infection with Menangle virus was detected in pigs at a piggery that had experienced reproductive disease, in pigs at two associated piggeries and in fruit bats in the region of the piggery. Two humans were infected. The mode of transmission between pigs is unknown, but spread by faecal or urinary excretion is postulated. This virus can be eradicated by the segregation of pigs into discrete age groups.

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Section: Cross-sectional Serological Studies Of Menangle Virus Infectmentioning

confidence: 96%

Epidemiology and control of Menangle virus in pigs

et al. 2001

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“…Rubulaviruses, which have been associated with abortions in pigs (10), have been isolated from these fruit bats, both in Australia and in Malaysia (3,7). In 1995 in Australia, a previously unidentified paramyxovirus, Hendra virus, infected horses and was transmitted to humans, where it induced fatal pulmonary complications (5,23).…”

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confidence: 99%

Nipah Virus: Vaccination and Passive Protection Studies in a Hamster Model

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et al. 2004

J Virol

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Nipah virus, a member of the paramyxovirus family, was first isolated and identified in 1999 when the virus crossed the species barrier from fruit bats to pigs and then infected humans, inducing an encephalitis with up to 40% mortality. At present there is no prophylaxis for Nipah virus. We investigated the possibility of vaccination and passive transfer of antibodies as interventions against this disease. We show that both of the Nipah virus glycoproteins (G and F) when expressed as vaccinia virus recombinants induced an immune response in hamsters which protected against a lethal challenge by Nipah virus. Similarly, passive transfer of antibody induced by either of the glycoproteins protected the animals. In both the active and passive immunization studies, however, the challenge virus was capable of hyperimmunizing the vaccinated animals, suggesting that although the virus replicates under these conditions, the immune system can eventually control the infection.

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“…Serum and plasma samples from Pteropus spp. were tested for antibodies against MenV in a VNT 42 . Samples giving positive results were titrated to endpoint.…”

Section: Methodsmentioning

confidence: 99%

“…Menangle virus (MenV) was isolated in August 1997 from stillborn piglets with deformities at a piggery near Sydney, NSW, Australia 41,42 and has been classified in the genus Rubulavirus of the family Paramyxoviridae 43,44 . Neutralising antibodies against MenV were detected in serum from pigs at the affected piggery, pigs at two associated piggeries, two humans who had contact with infected pigs and P. poliocephalus from a nearby colony 41,42,45,46 . Antibodies against MenV have also been detected in Pteropus spp.…”

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confidence: 99%