Reproductive Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in Female Rats: Ovulation, Hormonal Regulation, and Possible Mechanism(s)

Li, Xuelin; Johnson, Donald C.; Rozman, Karl K.

doi:10.1006/taap.1995.1157

Cited by 135 publications

(61 citation statements)

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“…Peak serum levels of FSH and LH were decreased by TCDD. In hypophysectomized immature rats treated with eCG and exogenous LH, number of rats ovulating was reduced by TCDD (10 and 60 µg/kg), suggesting that TCDD alters reproductive functions via effects on the HP axis as well as through direct effects on the ovary (Li et al, 1995). Single doses (0.03-30 µg/kg) of TCDD were also administered orally by gastric intubation to 22-day-old rats.…”

Section: Dioxinsmentioning

confidence: 99%

Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: A review of rodent and human data

Rasier

Toppari

Parent

et al. 2006

Molecular and Cellular Endocrinology

145

108

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Natural hormones and some synthetic chemicals spread into our surrounding environment share the capacity to interact with hormone action and metabolism. Exposure to such compounds can cause a variety of developmental and reproductive detrimental abnormalities in wildlife species and, potentially, in human. Many experimental and epidemiological data have reported that exposure of the developing fetus or neonate to environmentally relevant concentrations of some among these endocrine disrupters induces morphological, biochemical and/or physiological disorders in brain and reproductive organs, by interfering with the hormone actions. The impact of such exposures on the hypothalamic-pituitary-gonadal axis and subsequent sexual maturation is the subject of the present review. We will highlight epidemiological human studies and the effects of early exposure during gestational, perinatal or postnatal life in female rodents.

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Section: Dioxinsmentioning

confidence: 99%

Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: A review of rodent and human data

Rasier

Toppari

Parent

et al. 2006

Molecular and Cellular Endocrinology

145

108

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“…TCDD were dissolved and administered in 0.1mL of corn oil (C8267, Sigma) as a vehicle. We set 10 g/kg BW of TCDD as the highest dosage in this experiment because previous studies showed significant effects on the mouse endometrium or hormonal environment at this concentra-tion (De Vito et al, 1992;Li et al, 1995;Kitajima et al, 2004). In another five animals in each group, 10 g/kg BW alpha-naphthoflavone ( -NF, N5757, Sigma), an AhR antagonist (Merchant et al, 1993), was administered subcutaneously singly or simultaneously with 10 g/kg BW TCDD on day 4 of gestation.…”

Section: Tcdd Treatmentmentioning

confidence: 99%

Expression of the arylhydrocarbon receptor in the peri-implantation period of the mouse uterus and the impact of dioxin on mouse implantation

Kitajima

Khan

Fujishita

et al. 2004

Arch. Histol. Cytol.

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manner. This effect of TCDD was inhibited by the simultaneous administration of an AhR antagonist, alpha-naphthoflavone ( -NF). The spatio-temporal expression of AhR during the peri-implantation phase of the mouse uterus may indicate functional roles of this orphan receptor in fetomaternal interactions as well as substantiate the risk of exposure to chemicals such as dioxins during the reproductive period.

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“…On the other hand, TBARS levels significantly increased with TCDD treatment, which is associated with cell damage in uterine and ovarian tisues. In parallel, recent studies observed that environmental toxicants adversely affect ovarian function and fertility 19,20 . Chen et al 21 performed proteomic analysis of the ovaries by two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization tandem mass spectrometry and showed distinct changes in the levels of several proteins that are relevant markers of TCDD toxicity.…”

Section: Tcdd Toxicity On Uterine and Ovarian Tissuesmentioning

confidence: 92%

The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats

et al. 2016

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PURPOSE:To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis. METHODS:Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed. RESULTS:The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment. CONCLUSION:The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.

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Reproductive Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in Female Rats: Ovulation, Hormonal Regulation, and Possible Mechanism(s)

Cited by 135 publications

References 0 publications

Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: A review of rodent and human data

Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: A review of rodent and human data

Expression of the arylhydrocarbon receptor in the peri-implantation period of the mouse uterus and the impact of dioxin on mouse implantation

The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats

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