Reproductive endocrine-disrupting effects of triclosan: Population exposure, present evidence and potential mechanisms

Wang, Caifeng; Tian, Ying

doi:10.1016/j.envpol.2015.07.001

Cited by 176 publications

(84 citation statements)

References 63 publications

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“…It can be found in personal care products such as, soaps, toothpaste, and deodorants, as well as, toys and kitchenware (Dann and Hontela, 2011). Its chemical structure is similar to that of anthropogenic estrogens, and evidence suggests TCS disrupts hormone metabolism, displaces hormones from receptors and disrupts steroidogenic enzyme activity (Wang and Tian, 2015). There is also evidence from animal and in vitro studies of changes in reproductive hormone levels caused by TCS, albeit the evidence from the studies has varied (Wang and Tian, 2015).…”

Section: Introductionmentioning

confidence: 99%

Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women

Aker

Watkins

Johns

et al. 2016

Environmental Research

168

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Introduction Phenols and parabens are ubiquitous environmental contaminants. Evidence from animal studies and limited human data suggest they may be endocrine disruptors. In the current study, we examined associations of phenols and parabens with reproductive and thyroid hormones in 106 pregnant women recruited for the prospective cohort, “Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)”. Methods Urinary exposure biomarkers (bisphenol A, triclosan, benzophenone-3, 2,4-dichlorophenol, 2,5-dichlorophenol, butyl, methyl and propyl paraben) and serum hormone levels (estradiol, progesterone, sex hormone-binding globulin (SHBG), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone) were measured at up to two time points during pregnancy (16–20 weeks and 24–28 weeks). We used linear mixed models to assess relationships between exposure biomarkers and hormone levels across pregnancy, controlling for urinary specific gravity, maternal age, BMI and education. In sensitivity analyses, we evaluated cross-sectional relationships between exposure and hormone levels stratified by study visit using linear regression. Results An IQR increase in methyl paraben was associated with a 7.70% increase (95% CI 1.50, 13.90) in SHBG. Furthermore, an IQR increase in butyl paraben as associated with an 8.46% decrease (95% CI 16.92, 0.00) in estradiol, as well as a 9.34% decrease (95% CI −18.31, −0.38) in estradiol/progesterone. Conversely, an IQR increase in butyl paraben was associated with a 5.64% increase (95% CI 1.26, 10.02) in FT4. Progesterone was consistently negatively associated with phenols, but none reached statistical significance. After stratification, methyl and propyl paraben were suggestively negatively associated with estradiol at the first time point (16–20 weeks), and suggestively positively associated with estradiol at the second time point (24–28 weeks). Conclusions Within this ongoing birth cohort, certain phenols and parabens were associated with altered reproductive and thyroid hormone levels during pregnancy. These changes may contribute to adverse health effects in mothers or their offspring, but additional research is required.

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Section: Introductionmentioning

confidence: 99%

Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women

Aker

Watkins

Johns

et al. 2016

Environmental Research

168

View full text Add to dashboard Cite

show abstract

“…Bisphenol A is an endocrine disrupting chemical used in the manufacture of polycarbonate plastics and resins found in the linings of cans and bottles, among other products (Rubin 2011). Other phenolic compounds, including benzophenone-3, 2,5- dichlorophenol, and triclosan, may also have endocrine disrupting properties (Kim and Choi 2014; Takahashi and others 2007; Wang and Tian 2015). Benzophenone-3 is an ultraviolet filter used in sunscreen and cosmetics; 2,5-dichlorophenol is a metabolite of 1,4-dichlorobenzene, a chemical used in mothballs, deodorizers, and fumigants; and triclosan is a microbicide used in antibacterial soaps and other personal care products.…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to environmental phenols and childhood fat mass in the Mount Sinai Children's Environmental Health Study

Buckley

Herring

Wolff

et al. 2016

Environment International

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Early life exposure to endocrine disrupting chemicals may alter adipogenesis and energy balance leading to changes in obesity risk. Several studies have evaluated the association of prenatal bisphenol A exposure with childhood body size but only one study of male infants has examined other environmental phenols. Therefore, we assessed associations between prenatal exposure to environmental phenols and fat mass in a prospective birth cohort. We quantified four phenol biomarkers in third trimester maternal spot urine samples in a cohort of women enrolled in New York City between 1998 and 2002 and evaluated fat mass in their children using a Tanita scale between ages 4 and 9 years (173 children with 351 total observations). We estimated associations of standard deviation differences in natural log creatinine-standardized phenol biomarker concentrations with percent fat mass using linear mixed effects regression models. We did not observe associations of bisphenol A or triclosan with childhood percent fat mass. In unadjusted models, maternal urinary concentrations of 2,5-dichlorophenol were associated with greater percent fat mass and benzophenone-3 was associated with lower percent fat mass among children. After adjustment, phenol biomarkers were not associated with percent fat mass. However, the association between benzophenone-3 and percent fat mass was modified by child’s sex: benzophenone-3 concentrations were inversely associated with percent fat mass in girls (beta = −1.51, 95% CI = −3.06, 0.01) but not boys (beta = −0.20, 95% CI = −1.69, 1.26). Although we did not observe strong evidence that prenatal environmental phenols exposures influence the development of childhood adiposity, the potential antiadipogenic effect of benzophenone-3 in girls may warrant further investigation.

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“…Our decision was supported by the endocrine disrupting potential [19] and the inhibitory potential of Daphnia HR96 receptor which is a promiscuous endo-and xenobiotic nuclear receptor involved in acclimation to toxicants [20].…”

Section: Magnamentioning

confidence: 99%

How Does Experimental Design Modify the Result of Daphnia magna Heartbeat Rate Test? ─ Analyses of Factors Affecting the Sensitivity of the Test System

Fekete-Kertész

Stirling

Ullmann

et al. 2017

Period. Polytech. Chem. Eng.

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Reproductive endocrine-disrupting effects of triclosan: Population exposure, present evidence and potential mechanisms

Cited by 176 publications

References 63 publications

Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women

Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women

Prenatal exposure to environmental phenols and childhood fat mass in the Mount Sinai Children's Environmental Health Study

How Does Experimental Design Modify the Result of Daphnia magna Heartbeat Rate Test? ─ Analyses of Factors Affecting the Sensitivity of the Test System

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