Requirements for the Production of Microtablets: Suitability of Direct-Compression Excipients Estimated from Powder Characteristics and Flow Rates

Flemming, Jonathan; Mielck, Jobst B.

doi:10.3109/03639049509065904

Cited by 34 publications

(12 citation statements)

References 10 publications

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“…While Carr's compressibility index was somewhat useful in predicting capsule filling performance [12,13], Trowbridge et al [14] could not identify a relationship to tabletting performance. The critical orifice diameter determination has been used successfully to predict arching and plug formation in capsule filling [15,16] and in the manufacture of minitablets [17].…”

Section: Introductionmentioning

confidence: 99%

Development of a dual approach to assess powder flow from avalanching behavior

et al. 2000

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The purposes of this investigation were to develop a method to evaluate flow properties of powders from avalanching tests and to detect similarities and relationships between these data and conventional powder flow properties. The API AeroFlow automated flowability analyzer was tested using 6 pharmaceutical excipients. Data were presented as mean time to avalanche (MTA), scatter, and a classification based on the type of motion of the powder bed. Powders were also characterized in terms of particle size, particle shape, loss of weight on drying, Carr's compressibility index, and critical orifice diameter to prevent ratholing. A dual approach, which combines visual observation of the type of motion of the powder bed in the rotating drum with numerical descriptors such as MTA and scatter, was found to be more accurate in the assessment of powder flow than the current practice of using only MTA and scatter values. Statistical analysis established that there are relationships and similarities between the ranking of powder flow properties obtained from the avalanching test and Carr's compressibility index and the critical orifice diameter. An interaction between particle size and shape, both influencing powder flow, when evaluated with these methods was found. The assessment of the flowability of powders on the basis of avalanching tests should include both the determination of numerical descriptors of flow such as MTA and scatter, and a determination of the type of motion of the powder bed in order to increase the sensitivity of the method to small changes in powder flow properties.

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Section: Introductionmentioning

confidence: 99%

Development of a dual approach to assess powder flow from avalanching behavior

et al. 2000

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“…Furthermore, a number of special direct techniques to study avalanching in powders have been described (9)(10)(11)(12). Indirect methods include, e.g., angles of repose, shear cell determinations (5,8,11,13,14), and measurements of critical orifice diameter (10,(15)(16)(17)(18). Recently, flow properties of powders were measured using a more advanced ring shear cell tester which makes it possible to substantially reduce the amount of powder and labor required to characterize flow properties (19,20).…”

Section: Introductionmentioning

confidence: 99%

Development of a New Method to Get a Reliable Powder Flow Characteristics Using Only 1 to 2 g of Powder

et al. 2010

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Abstract. In powder technology, it is often important to directly measure real powder flow rate from a small amount of powder. For example, in pharmaceutical industry, a frequent problem is to determine powder flow properties of new active pharmaceutical ingredient (API) in an early stage of the development when the amount of API is limited. The purpose of this paper is to introduce a new direct method to measure powder flow when the material is poorly flowing (cohesive) and the amount of material is about 1 to 2 g. The measuring system was simple, consisting of a flow chamber and electronic balance and an automated optical detection system, and for each measurement, only 1 to 2 g of sample was required. Based on the results obtained with this testing method, three selected sugar excipients, three grades of microcrystalline cellulose, and APIs (caffeine, carbamazepine, and paracetamol) can be classified as freely flowing, intermediate flowing, and poorly flowing powders, respectively. The average relative standard deviation for the flow time determinations was not more than 2-10%. The present novel flowability testing method provides a new tool for a rapid determination of flowing characteristics of powders (e.g., inhalation powders) and granules at a small scale.

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“…The narrow diameter of the die requires an excellent powder fl uidity and a narrow maximum particle size range to prevent occlusion. In a study by Mielck and Flemming (1995), [12], it is found that when D / dp 99 & gt; 3, the powder has the desired particle size, and when D / dp 99 & lt; 3, the powder fl ow may be disrupted (the minimum particle diameter (D) has been associated with the maximum particle size which represents 99% of the mixture). In addition to the content, the size of the tablets is also infl uential on mechanical resistance.…”

Section: Formulation and Production Requirementsmentioning

confidence: 99%

Mini Tablets: A Short Review-Revision

Ilhan¹,

Uğurlu²,

Kerımoğlu³

2017

Open J Chem

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Mini tablets are solid dosage forms with a diameter ≤ 3 mm and separated into subunits of conventional tablets. Production methods are similar to standard tablets, but the only difference is the use of multiple punches. They have advantageous for use in patients suffering from swallowing diffi culty and receiving multiple drug treatment. They provide a more effective treatment by reducing the fl uctuation in the drug's release profi le. At the same time, different release systems can be used together. In addition, mini tablets have a number of advantages over single unit dosage forms, and in recent years the prominence continues to increase. In the light of this information, the advantages and disadvantages of mini tablets, production equipment, formulation designs, different emission characteristics and evaluation criteria are emphasized in this compilation.

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Requirements for the Production of Microtablets: Suitability of Direct-Compression Excipients Estimated from Powder Characteristics and Flow Rates

Cited by 34 publications

References 10 publications

Development of a dual approach to assess powder flow from avalanching behavior

Development of a dual approach to assess powder flow from avalanching behavior

Development of a New Method to Get a Reliable Powder Flow Characteristics Using Only 1 to 2 g of Powder

Mini Tablets: A Short Review-Revision

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