Research on the mechanism of Chinese herbal medicine Radix Paeoniae Rubra in improving chronic pelvic inflammation disease by regulating PTGS2 in the arachidonic acid pathway

Li, Xiaohong; Liu, Yanru; Jiang, Dahai; Tang, Zhishu; Qian, Dawei; Song, Zhong-Xing; Chen, Lin; Xue-yin, Shi; Yang, Ning-Juan; Yan, Yongmei; Chang, Ai-Bing

doi:10.1016/j.biopha.2020.110052

Cited by 22 publications

(18 citation statements)

References 22 publications

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“…RAC-alpha serine/threonine-protein kinase AKT1 had a close relationship with gynecologic disease, such as endometriosis [43] and endometrial carcinoma [44]. In our study, it presented a signi cant relevance to PD, which could provide evidences for further studies.Prostaglandin G/H synthase 2 PTGS2 is an inducible prostaglandin enzyme whose derivative(PGE2 and PGI2) are the major mediators in decidualization [45].Immunohistochemical tests, western blotting (WB) assays and polymerase chain reaction (PCR)show that PTGS2 expression in the uterine myometrium and glands is directly related to organ in ammation intensity [46].One pathological mechanism of PD is the increase of PGE2 and PGF2α [47], verifying the great effect of PTGS2 on PD.…”

Section: Discussionmentioning

confidence: 99%

Investigating the Mechanism of Guizhi Fuling Formula in the Treatment of Primary Dysmenorrhea based on Network Pharmacology and Molecular Docking

Sun

Wang

et al. 2021

Preprint

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Background: Primary dysmenorrhea(PD)is the most common gynecologic disorder.Despite the prevalence is high, it is often underdiagnosed,undertreated and normalized even by patients themselves. Guizhi Fuling Formula (GFF) is experientially used for the treatment of PD in a long time. Therefore, the efficiency and potential mechanism are waiting to identify.Methods: We adopted network pharmacology integrated molecular docking strategy in this study.Based on published literatures, the relative compounds of GFF were selected preliminarily. Secondly, the putative targets of PD were obtained by wide-searching DisGeNET, OMIM, Drugbank and GeneCards databases.With protein-protein interaction(PPI) analysis, GO and KEGG pathway enrichment analysis and molecular docking ,we systematically evaluated the relationship of herb ingredients and disease targets.Results: The results showed that 30 ingredients of GFF and 43 hub targets made a difference.Under the further analysis,8 targets(EGFR,AKT1,PTGS2,TNF,ESR1,AHR,CTNNB1,CXCL8) were recognized as key therapeutic targets with excellent binding. The enrichment analyses indicated that the GFF had the potential to influence varieties of biological pathways, especially the pathways in cancer and steroid hormone biosynthesis, which play an important part in the pathogenesis of primary dysmenorrhea.Conclusion: GFF influenced primary dysmenorrhea through the synergistic effect of multiple components, multiple targets, and multiple pathways.This study predictedthe potential mechanism, hope that could made contribution for clinical application and scientific research.

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Section: Discussionmentioning

confidence: 99%

Investigating the Mechanism of Guizhi Fuling Formula in the Treatment of Primary Dysmenorrhea based on Network Pharmacology and Molecular Docking

Sun

Wang

et al. 2021

Preprint

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“…Pharmacological studies have indicated that RPR possesses anti-thrombotic, hypolipidemic, anti-arteriosclerosis [11] and hepatoprotective effects [12] , which made it potential for cardiovascular and cerebrovascular diseases [13] , [14] . According to previous studies [15] , the mechanisms of these pharmacological effects may be related to the active ingredients in RPR that can inhibit inflammation or antioxidant (Structures shown in Fig. 1 ).…”

Section: Introductionmentioning

confidence: 89%

Ultrasound-assisted preparation of ‘Ready-to-use’ extracts from Radix Paeoniae Rubra with natural deep eutectic solvents and neuroprotectivity evaluation of the extracts against cerebral ischemic/ reperfusion injury

Wan

Yang

et al. 2022

Ultrasonics Sonochemistry

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“…Radix Paeoniae Rubra is the dry root of herbaceous peony, and has the effect of clearing heat and cooling blood, promoting blood circulation, and removing blood stasis. Studies have shown that Radix Paeoniae Rubra exerts anti-tumor effect ( Xu et al, 2013 ), improves chronic inflammation disease ( Li X. H. et al, 2020 ), ameliorates lupus nephritis and lupus nephritis ( Wang W. et al, 2020 ), protects against myocardial ischemic injury ( Ke et al, 2017 ), exerts neuroprotective effects on ischemia stroke mice ( Luo et al, 2020 ), has anti-thrombotic effect ( Xie et al, 2017 ), ameliorates focal cerebral ischemic in rats ( Gu et al, 2016 ), and promotes recovery of neurological function of stroke convalescent patients ( Zhang et al, 2020 ).…”

Section: Pharmacological Effects On the Active Ingredients Of Buyang ...mentioning

confidence: 99%

A Review of Traditional Chinese Medicine, Buyang Huanwu Decoction for the Treatment of Cerebral Small Vessel Disease

Sun

Wang

et al. 2022

Front. Neurosci.

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Cerebral small vessel disease (CSVD) is often referred to as “collaterals disease” in traditional Chinese medicine (TCM), and commonly includes ischemic and hemorrhagic CSVD. TCM has a long history of treating CSVD and has demonstrated unique efficacy. Buyang Huanwu Decoction (BHD) is a classical TCM formula that has been used for the prevention and treatment of stroke for hundreds of years. BHD exerts its therapeutic effects on CSVD through a variety of mechanisms. In this review, the clinical and animal studies on BHD and CSVD were systematically introduced. In addition, the pharmacological mechanisms, active components, and clinical applications of BHD in the treatment of CSVD were reviewed. We believe that an in-depth understanding of BHD, its pharmacological mechanism, disease-drug interaction, and other aspects will help in laying the foundation for its development as a new therapeutic strategy for the treatment of CSVD.

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Research on the mechanism of Chinese herbal medicine Radix Paeoniae Rubra in improving chronic pelvic inflammation disease by regulating PTGS2 in the arachidonic acid pathway

Cited by 22 publications

References 22 publications

Investigating the Mechanism of Guizhi Fuling Formula in the Treatment of Primary Dysmenorrhea based on Network Pharmacology and Molecular Docking

Investigating the Mechanism of Guizhi Fuling Formula in the Treatment of Primary Dysmenorrhea based on Network Pharmacology and Molecular Docking

Ultrasound-assisted preparation of ‘Ready-to-use’ extracts from Radix Paeoniae Rubra with natural deep eutectic solvents and neuroprotectivity evaluation of the extracts against cerebral ischemic/ reperfusion injury

A Review of Traditional Chinese Medicine, Buyang Huanwu Decoction for the Treatment of Cerebral Small Vessel Disease

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