Research on the synthesis of chitosan@MIL-100(Fe)

Abstract

Objective: Studying new carrier materials to solve the problems of bioavailability and side effects of drugs in the body and choose the suitable carrier to coat the drug. This carrier not only improves the release and absorption of drug molecules in the body, but also significantly improves the bioavailability and reduces the toxic side effects of high concentrated drugs. Therefore, this paper focuses on the research of the synthesis of a new carrier material. Methods:Using ferric nitrate as iron source, first add ferric nitrate, 1,3,5-benzene tricarbonic acid, chitosan solution and deionized water pro rata, then synthesize the product using mechanical stirring, and purify and dry the product. Results:The maximum yield of chitosan is obtained when the concentration of chitosan is 1% using mechanical stirring method, and the yield is 0.6330 g. Conclusion:The results show that the thinner the concentration of chitosan solution is, the better synthesizes the chitosan@MIL-100(Fe) and the higher the yield is. And it reaches the best result when the concentration is 1%.

Chitosan-Coated MIL-100(Fe) as an Anticancer Drug Carrier: Theoretical and Experimental Investigation

“…Combining two or three of these materials to produce a composite can create a novel opportunity to develop a carrier with optimized properties. 1 In recent years, the field of biomedical engineering has made significant progress in drug delivery, leading to the evaluation of different drug carriers, such as lipids, polymers, metals, carbonic structures, carbides, and MOFs. 2 MOFs, constructed from metal ions and organic ligands to form porous materials with strong coordination bonds, have emerged as a promising tool to enhance the effectiveness of existing drugs.…”

“…Different materials, including synthetic and natural polymers, ceramics, metals, metal–organic frameworks (MOFs), and biomolecules, each have their advantages and disadvantages. Combining two or three of these materials to produce a composite can create a novel opportunity to develop a carrier with optimized properties . In recent years, the field of biomedical engineering has made significant progress in drug delivery, leading to the evaluation of different drug carriers, such as lipids, polymers, metals, carbonic structures, carbides, and MOFs .…”

“…The calculation was performed based on the interatomic force field, 9,17,18 and the most appropriate interatomic force field was chosen based on the atomic structure of the system to obtain accurate results. The Dreiding potential was used as a reference, and the potential energy of molecular distribution was determined by bonded (E val ) and nonbonded (E nb ) interactions: (1) Nonbonded interactions between atoms were expressed using Lennard-Jones (LJ) potential as follows:…”