Research progress of coumarins and their derivatives in the treatment of diabetes

Pan, Yinbo; Li, Teng; Wang, Xiaojing; Sun, Jie

doi:10.1080/14756366.2021.2024526

Cited by 40 publications

(25 citation statements)

References 91 publications

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“…The rapid increase of diabetes and its underlying patients led to a substantial increase in the number of diabetic cardiovascular complications ( 98 ). In fact, the effect of diabetes on atherosclerotic VSMCs is not simply regulated by a certain mechanism, but the result of the interaction of multiple factors ( 99 ).…”

Section: Diabetes and Vsmcsmentioning

confidence: 99%

Role of advanced glycation end products on vascular smooth muscle cells under diabetic atherosclerosis

Lin

Yin²,

Yang³

et al. 2022

Front. Endocrinol.

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Atherosclerosis (AS) is a chronic inflammatory disease and leading cause of cardiovascular diseases. The progression of AS is a multi-step process leading to high morbidity and mortality. Hyperglycemia, dyslipidemia, advanced glycation end products (AGEs), inflammation and insulin resistance which strictly involved in diabetes are closely related to the pathogenesis of AS. A growing number of studies have linked AGEs to AS. As one of the risk factors of cardiac metabolic diseases, dysfunction of VSMCs plays an important role in AS pathogenesis. AGEs are increased in diabetes, participate in the occurrence and progression of AS through multiple molecular mechanisms of vascular cell injury. As the main functional cells of vascular, vascular smooth muscle cells (VSMCs) play different roles in each stage of atherosclerotic lesions. The interaction between AGEs and receptor for AGEs (RAGE) accelerates AS by affecting the proliferation and migration of VSMCs. In addition, increasing researches have reported that AGEs promote osteogenic transformation and macrophage-like transformation of VSMCs, and affect the progression of AS through other aspects such as autophagy and cell cycle. In this review, we summarize the effect of AGEs on VSMCs in atherosclerotic plaque development and progression. We also discuss the AGEs that link AS and diabetes mellitus, including oxidative stress, inflammation, RAGE ligands, small noncoding RNAs.

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Section: Diabetes and Vsmcsmentioning

confidence: 99%

Role of advanced glycation end products on vascular smooth muscle cells under diabetic atherosclerosis

Lin

Yin²,

Yang³

et al. 2022

Front. Endocrinol.

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“…Coumarin rings are present in many bioactive compounds, which are widely found in nature as well as in biologically active new synthetic compounds [ 9 ]. These heterocyclic compounds exhibit a range of important pharmacological and biological activities, such as antidiabetic [ 10 ], anticancer [ 11 ], antifungal [ 12 ], and antibacterial [ 13 ] activity. Many derivatives containing coumarin ring display multifunctional bioactivity [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Many derivatives containing coumarin ring display multifunctional bioactivity [ 6 ]. A variety of coumarin derivatives with antidiabetic activity have been designed and synthesized as well as isolated from plants, in particular, for the treatment of Type 2 diabetes mellitus [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, molecular docking study and molecular dynamics simulation of new coumarin-pyrimidine hybrid compounds having anticancer and antidiabetic activity

et al. 2023

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Coumarin-pyrimidine hybrid compounds were synthesized by condensation reaction of α,β-unsaturated ketones of 6-acetyl-5-hydroxy-4-methylcoumarin with guanidine. The reaction yields were of 42–62%. The antidiabetic and anticancer activities of these compounds were examined. These compounds displayed low toxicity to two cancer cell lines (including KB and HepG2 ones), but exhibited remarkably active against α-amylase with IC 50 values of 102.32 ± 1.15 μM to 249.52 ± 1.14 μM and against α-glucosidase with IC 50 values of 52.16 ± 1.12 μM to 184.52 ± 1.15 μM. Amongst these compounds, 6c was the best inhibitory activity against α-amylase, and 6f had the highest activity against α-glucosidase. The kinetics of inhibitor 6f was competitive α -glucosidase inhibitor property. ADMET predictions showed that almost all synthesized compounds exhibited drug-like activity. IFD and MD simulations were carried out on enzymes 4W93 and 5NN8 to elucidate inhibitory potential of 6c and 6f against tested enzymes. The binding free energy calculation by MM-GBSA approach showed that Coulomb, lipophilic and van der Waals energy terms are major contributors for the inhibitor binding. Molecular dynamics simulations in water solvent system were carried out for the 6f /5NN8 complex to elucidate the variability of active interactions between ligand 6f and active pockets of this enzyme. Graphical Abstract

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“…In recent years, some studies have shown that some natural compounds have the effects of lowering blood glucose, lowering blood lipid and anti-oxidation, and have good effects in the treatment of diabetes complications [ 13 , 14 ]. In this review, we searched the PubMed database and Google scholar with “(Diabetes nephropathy) OR (Diabetic kidney disease)”, found a recently published article on the treatment of DKD with a natural compound, and then searched with “((Diabetes nephropathy) OR (Diabetic kidney disease)) AND (compound)” to find all the studies on the treatment of DKD with this compound, and selected articles with in-depth mechanism research for review.…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanistic Pathways Targeted by Natural Compounds in the Prevention and Treatment of Diabetic Kidney Disease

et al. 2022

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Diabetic kidney disease (DKD) is one of the most common complications of diabetes, and its prevalence is still growing rapidly. However, the efficient therapies for this kidney disease are still limited. The pathogenesis of DKD involves glucotoxicity, lipotoxicity, inflammation, oxidative stress, and renal fibrosis. Glucotoxicity and lipotoxicity can cause oxidative stress, which can lead to inflammation and aggravate renal fibrosis. In this review, we have focused on in vitro and in vivo experiments to investigate the mechanistic pathways by which natural compounds exert their effects against the progression of DKD. The accumulated and collected data revealed that some natural compounds could regulate inflammation, oxidative stress, renal fibrosis, and activate autophagy, thereby protecting the kidney. The main pathways targeted by these reviewed compounds include the Nrf2 signaling pathway, NF-κB signaling pathway, TGF-β signaling pathway, NLRP3 inflammasome, autophagy, glycolipid metabolism and ER stress. This review presented an updated overview of the potential benefits of these natural compounds for the prevention and treatment of DKD progression, aimed to provide new potential therapeutic lead compounds and references for the innovative drug development and clinical treatment of DKD.

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Research progress of coumarins and their derivatives in the treatment of diabetes

Cited by 40 publications

References 91 publications

Role of advanced glycation end products on vascular smooth muscle cells under diabetic atherosclerosis

Role of advanced glycation end products on vascular smooth muscle cells under diabetic atherosclerosis

Design, synthesis, molecular docking study and molecular dynamics simulation of new coumarin-pyrimidine hybrid compounds having anticancer and antidiabetic activity

Molecular Mechanistic Pathways Targeted by Natural Compounds in the Prevention and Treatment of Diabetic Kidney Disease

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