Research Progress of Materials and Fabrication Technologies of Microfluidic Chip

Cheng, Yong Qiang; Yang, Li; Guo, Cui Lian; Zhou, Yuqing; Yang, Ying‐Wei

doi:10.4028/www.scientific.net/amr.542-543.891

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…With further application of micro total analysis systems (µTAS), a broad variety of materials are evolving and updating [10]. To date, MCE is achieved using mainly inorganic materials and organic materials, and more low-cost and simple fabrication methods are constantly emerging [11]. In the past two decades, various materials have been introduced in microfluidic chips, and choosing the right material is the first and most crucial step in microfluidic chip fabrication [12].…”

Section: Preparation Of Mcementioning

confidence: 99%

See 1 more Smart Citation

Recent progress in preparation and application of microfluidic chip electrophoresis

Cong

et al. 2015

J. Micromech. Microeng.

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Since its discovery in 1990, microfluidic chip electrophoresis (MCE) has allowed the development of applications with small size, fast analysis, low cost, high integration density and automatic level, which are easy to carry and have made commercialization efficient. MCE has been widely used in the areas of environmental protection, biochemistry, medicine and health, clinical testing, judicial expertise, food sanitation, pharmaceutical checking, drug testing, agrochemistry, biomedical engineering and life science. As one of the foremost fields in the research of capillary electrophoresis, MCE is the ultimate frontier to develop the miniaturized, integrated, automated all-in-one instruments needed in modern analytical chemistry. By adopting the advanced technologies of micro-machining, lasers and microelectronics, and the latest research achievements in analytical chemistry and biochemistry, the sampling, separation and detection systems of commonly used capillary electrophoresis are integrated with high densities onto glass, quartz, silicon or polymer wafers to form the MCE, which can finish the analysis of multi-step operations such as injection, enrichment, reaction, derivatization, separation, and collection of samples in a portable, efficient and super high speed manner. With reference to the different technological achievements in this area, the latest developments in MCE are reviewed in this article. The preparation mechanisms, surface modifications, and properties of different materials in MCE are compared, and the different sampling, separation and detection systems in MCE are summarized. The performance of MCE in analysis of fluorescent substance, metallic ion, sugar, medicine, nucleic acid, DNA, amino acid, polypeptide and protein is discussed, and the future direction of development is forecast.

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Section: Preparation Of Mcementioning

confidence: 99%

“…Glass microchips have been used in chemical analysis for their excellent optical properties. At the same time, there exist negative charges on the glass surface, which support reproducible electroosmotic flow (EOF) [11]. Bai et al presented a facile approach for wettability-patterning of the microchannels of glass chips [20].…”

Section: Mce Of Inorganic Materialsmentioning

confidence: 99%

Recent progress in preparation and application of microfluidic chip electrophoresis

Cong

et al. 2015

J. Micromech. Microeng.

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“…Particularly, polymer devices with microstructures are broadly used in many important fields such as precision energy and optical system, microfluidic chips, and drug delivery devices [ 3 , 4 , 5 , 6 ]. Therefore, there is a strong demand for miniature polymer devices and components with high form accuracy and surface quality [ 7 , 8 ]. PMMA has good comprehensive mechanical properties, and it is at the forefront of general-purpose plastics.…”

Section: Introductionmentioning

confidence: 99%

Thermal Effect on Poly(methyl methacrylate) (PMMA) Material Removal in the Micromilling Process

et al. 2020

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Poly(methyl methacrylate) (PMMA) is of growing interest in the application of microfluidic devices and high precision optical elements due to its excellent moldability and formability. Micromilling is one of the micromachining methods which has been extensively used to manufacture polymer components. In this study, a high-speed micromilling method was used to manufacture polymer with high form accuracy and surface quality. The processing temperature effects on the surface quality were investigated in detail. The dynamic mechanical analysis (DMA) experiment was used to study the material mechanical property under different temperatures. According to the DMA results, the PMMA sample is in the glass and viscoelastic state during the milling process. The cutting chips under various processing temperatures are classified into three kinds according to their shapes: roll, sheet, and sinter. The surface roughness of samples with sheet and roll cutting chips is smaller than that of sinter cutting chips. To obtain a better machining bottom surface and edge shape, the processing temperature below 70 °C is recommended according to the results. This work is of great value for the study of polymer removal mechanism and optimization of processing parameters for the industry.

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“…Microfluidic chip is generally employed to deal with the behavior, precise control, and manipulation of fluids, which are geometrically constrained to a small, typically sub-millimeter, and scale. Silicon, quartz, or glass is usually used to fabricate microfluidic chips by means of complicated and cleanroom-based multi-step processes such as lithography [3,4]. However, such conventional processing methods cannot satisfy the requirements of high efficiency and low cost [5,6].…”

Section: Introductionmentioning

confidence: 99%

Mechanism and solutions of appearance defects on microfluidic chips manufactured by UV-curing assisted injection molding

Xie

et al. 2016

Journal of Polymer Engineering

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Abstract A novel method for the chemical manufacturing UV-curing assisted injection molding was proposed in this paper. A prototype of UV-curing injection molding apparatus has been manufactured. By using the prototype, we have successfully fabricated microfluidic chips, which can be practically applied in micro mixing experiments. Similar to the thermoplastic parts molded by traditional injection molding, the appearance defects such as bubbles also occurred on products fabricated by UV-curing injection molding. The generation process of bubble defect has been observed and captured through the visualization device. Because there is no gas produced in the polymerization chemical reaction, the shrinkage was considered to be the essential reason of bubble defect. In this paper, the solution of bubble defect was studied by employing single factor control variable method from the aspects of process parameters, materials, and mode of irradiation. It was noted that the bubble defect could be improved by increasing holding pressure, reducing irradiation intensity, and improving viscosity. Nevertheless, the achievement of process parameters was limited. On equal experimental conditions of process, equipment, and material, results revealed that the dynamic irradiation pattern can improve the feeding capacity significantly in UV-curing injection molding. It is further demonstrated that the bubble defect is caused by the polymerization shrinkage. Eventually, we obtained the microfluidic chips with good surface quality, high dimensional accuracy, and high transparency by UV-curing injection molding. Moreover, it provides a feasible high efficiency and low cost manufacture technology for microfluidic chips in the future.

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Research Progress of Materials and Fabrication Technologies of Microfluidic Chip

Cited by 7 publications

References 32 publications

Recent progress in preparation and application of microfluidic chip electrophoresis

Recent progress in preparation and application of microfluidic chip electrophoresis

Thermal Effect on Poly(methyl methacrylate) (PMMA) Material Removal in the Micromilling Process

Mechanism and solutions of appearance defects on microfluidic chips manufactured by UV-curing assisted injection molding

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