Research Progress on Chemical Constituents of Lonicerae japonicae flos

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Lonicera Linn. is an important genus of the family Caprifoliaceae comprising of approximately 200 species, and some species of which have been usually used in traditional Chinese medicine for thousands of years. Some species of this genus can also be used in functional foods, cosmetics and other applications. The saponins, as one of most important bioactive components of the Lonicera Linn. genus, have attracted the attention of the scientific community. Thus, a comprehensive and systematic review on saponins from the genus is indispensable. In this review, 87 saponins and sapogenin from the genus of Lonicera Linn., together with their pharmacological activities including hepatoprotective, anti-inflammatory, anti-bacterial, anti-allergic, anti-tumor, and immunomodulatory effects, and hemolytic toxicity were summarized.

Section: Introductionmentioning

confidence: 99%

A Review: The Triterpenoid Saponins and Biological Activities of Lonicera Linn.

Fang

Yang

et al. 2020

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“…More than 200 compounds such as flavonoids, organic acid, iridoids, saponins and volatile oil have been identified in L . japonica , and these active ingredients greatly contribute to its excellent function in the clinic [16,17,18,19]. Phenolic acids, especially chlorogenic acid and caffeic acid, are regarded as the main anti-inflammatory active ingredients.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Multiple Bioactive Constituents in the Flower and the Caulis of Lonicera japonica Based on UFLC-QTRAP-MS/MS Combined with Multivariate Statistical Analysis

Cai¹,

Wang²,

Zou³

et al. 2019

Lonicerae japonicae flos (LJF) and Lonicerae japonicae caulis (LJC) are derived from different parts of Lonicera japonica Thunb. (Caprifoliaceae), and have been used as herbal remedies to treat various diseases for thousands of years with confirmed curative effects. However, little attention has been paid to illustrating the differences in efficacy from the perspective of phytochemistry. In the present study, a simultaneous determination of 47 bioactive constituents, including 12 organic acids, 12 flavonoids, six iridoids, 13 amino acids and four nucleosides in 44 batches of LJF and LJC samples from different habitats and commercial herbs was established based on ultra-fast liquid chromatography tandem triple quadrupole mass spectrometry (UFLC-QTRAP-MS/MS). Moreover, principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA) and t-test were then performed to classify and reveal the differential compositions of LJF and LJC according to the content of the tested constituents. The results demonstrated that the types and contents of chemical components (e.g., isochlorogenic acid A, chlorogenic acid, neochlorogenic acid, quinic acid, secologanic acid, luteoloside, loganin, secoxyloganin, morroniside and L-isoleucine) were significantly different, which may lead to the classification and the differences in efficacy of LJF and LJC. Our findings not only provide a basis for the comprehensive evaluation and intrinsic quality control of LJF and LJC, but also pave the way for discovering the material basis contributing to the different properties and efficacies of the two medicinal materials at the phytochemical level.

“…In addition, it can also been used in functional foods, cosmetics and other applications [2]. Modern phytochemistry and pharmacology studies have shown that chlorogenic acids, iridoid glucosides, polyphenols, flavonoids, triterpenoid saponins, organic acids and volatile oils were the active ingredients in Lonicera Species [3,4,5]. Iridoid glucosides, as a special class of monoterpenoids, have been frequently reported to display a variety of pharmacological properties such as anti-inflammatory [6], antibacterial [7], anti-virus [8], anti-allergic [9], and hepatoprotective effects [10], and play important roles in the known effects of L. Japonicae Flos.…”

Section: Introductionmentioning

confidence: 99%

Separation of Five Iridoid Glycosides from Lonicerae Japonicae Flos Using High-Speed Counter-Current Chromatography and Their Anti-Inflammatory and Antibacterial Activities

Yang

Fang

et al. 2019

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A high-speed counter-current chromatography (HSCCC) method, using a two-phase solvent system composed of ethyl acetate/n-butanol/methanol/water (5:1:1:5, v/v/v/v), was successfully established to separate the five iridoid glucosides 7-O-ethyl sweroside (1), secologanin dimethylacetal (2), adinoside F (3), (7R)-secologain n-butyl methyl acetal (4) and adinoside G (5) from Lonicerae Japonicae Flos. Their purities were 96.8%, 98.5%, 93.3%, 98.0% and 99.9%, respectively. All the iridoid glucosides were identified by HR-ESI-MS, 1D and 2D NMR. Compounds 3 and 5 are new iridoid glucosides. The anti-inflammatory tests showed that compounds 1–5 all expressed moderate inhibitory effects on β-glucuronidase release in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF) with IC50 values ranging from 4.52 to 6.50 µM, while the antibacterial assays demonstrated that all the compounds displayed mild inhibitory activities against Staphylococcus aureus ATCC 25923 with MIC values ranging from 13.7 to 26.0 µg/mL.