Research progress on liposomes: Application in food, digestion behavior and absorption mechanism

Li, Weilin; Hou, Yingying; Jin, Yangyi; Wang, Yanping; Xu, Xiankang; Han, Jianzhong

doi:10.1016/j.tifs.2020.08.012

Cited by 130 publications

(75 citation statements)

References 93 publications

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“…Liposomes are currently some of the most often studied nanocarriers for the delivery of active substances. They are spherical-shaped vesicular structures with a size range of 25 nm to a few microns, formed from phospholipids containing a hydrophilic head and two hydrophobic tails [ 8 , 9 ]. The use of liposomes as a drug delivery system offers numerous advantages such as: high biodegradability and biocompatibility with low toxicity, ability of self-assembly, possibility of simple removal from the body and increased efficacy and bioavailability of encapsulated compounds [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Surface-Modified Bilosomes as Functional and Biocompatible Nanocarriers of Hybrid Compounds

Waglewska¹,

Pucek-Kaczmarek²,

Bazylińska³

2020

Nanomaterials

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In the present contribution, we demonstrate a new approach for functionalization of colloidal nanomaterial consisting of phosphatidylcholine/cholesterol-based vesicular systems modified by FDA-approved biocompatible components, i.e., sodium cholate hydrate acting as a biosurfactant and Pluronic P123—a symmetric triblock copolymer comprising poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) blocks Eight novel bilosome formulations were prepared using the thin-film hydration method followed by sonication and extrusion in combination with homogenization technique. The optimization studies involving the influence of the preparation technique on the nanocarrier size (dynamic light scattering), charge (electrophoretic light scattering), morphology (transmission electron microscopy) and kinetic stability (backscattering profiles) revealed the most promising candidate for the co-loading of model active compounds of various solubility; namely, hydrophilic methylene blue and hydrophobic curcumin. The studies of the hybrid cargo encapsulation efficiency (UV-Vis spectroscopy) exhibited significant potential of the formulated bilosomes in further biomedical and pharmaceutical applications, including drug delivery, anticancer treatment or diagnostics.

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Section: Introductionmentioning

confidence: 99%

Novel Surface-Modified Bilosomes as Functional and Biocompatible Nanocarriers of Hybrid Compounds

Waglewska¹,

Pucek-Kaczmarek²,

Bazylińska³

2020

Nanomaterials

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“…Liposomes are extensively used as carriers for numerous molecules in the cosmetic and pharmaceutical industries 13,14 .…”

Section: Sangam Singhmentioning

confidence: 99%

Method Development and Characterization of Liposomal Formulation of Isotretinoin

Ahmad¹,

Kumar²,

Singh³

et al. 2021

Borneo J Pharm

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This study aims to develop a liposomal drug delivery system of isotretinoin, an acne drug-using spray drying, as a cost-effective and time-effective technique. The liposomal formulation was prepared by using spray drying; three different strategies were adopted: suspension spray drying (SSD), thin-film hydration and spray drying (TFHSD), and emulsion spray drying (ESD). Isotretinoin was 99% bound with lipid, so lipids hydrogenated soy phosphatidylcholine (HSPC), distearoyl phosphatidylglycerol (DSPG), and cholesterol were selected for the formulation development. The HSPC, DSPG, cholesterol, and isotretinoin were taken in the ratio 4 : 1 : 0.16 : 3.1 mmol. In vitro drug release studies, microscopy, drug content, and related substance characterizations were done to formulate each strategy of spray drying prepared dry liposomes of isotretinoin. Results were compared with the USP monograph of isotretinoin. It was revealed that isotretinoin's liposomal formulation using ESD was having drug release according to the USP limits. Drug content was also according to the USP requirement; no free drug crystals were found in microscopy, multivesicular vesicles were found in shape, a particle size of up 60 µ was found. The ESD technique was a successful, time-effective, and cost-effective technique for preparing a liposomal drug delivery system for isotretinoin.

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“…Currently, targeted drug delivery for the inhibition of lung metastasis is mainly based on size-driven systems such as nanoparticles, micelles, and liposomes [ 7 , 8 , 9 ]. Liposomes are widely used as drug carriers due to their high drug loading capacity and safety [ 10 , 11 ]. The simultaneous presence of a phospholipid bilayer and an inner aqueous core allows the co-encapsulation of lipophilic and hydrophilic drugs, making liposomes an efficient nanoscale drug delivery system [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Chondroitin Sulfate-Modified Liposomes for Targeted Co-Delivery of Doxorubicin and Retinoic Acid to Suppress Breast Cancer Lung Metastasis

Zhang

Luo

2021

Pharmaceutics

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Breast cancer treatment remains challenging due to high levels of cell metastasis. Chemotherapy drug combinations can inhibit both tumor growth in situ and metastasis to distant organs. Therefore, here, we developed chondroitin sulfate liposomes (CSLs) as a carrier for the co-delivery of retinoic acid (RA) and doxorubicin (DOX) and examined their efficiency in suppressing lung metastasis of breast cancer. CSLs were prepared using CS–deoxycholic acid conjugates and found to encapsulate both RA and DOX via hydrophobic and hydrophilic interactions. The resulting DOX+RA-CSLs were uniformly spherical and showed good serum stability and encapsulation efficiency of 98.7% ± 1.3% for RA and 90.8% ± 2.9% for DOX. Pharmacodynamic experiments in vitro and in vivo also revealed that DOX+RA-CSLs had better anticancer and anti-metastatic activity than CS-free liposomes, single drug-loaded liposomes, and free drug solutions at the same dose (2 mg/kg DOX or RA). Our results suggest that this liposomal delivery system can effectively suppress lung metastasis of breast cancer.

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Research progress on liposomes: Application in food, digestion behavior and absorption mechanism

Cited by 130 publications

References 93 publications

Novel Surface-Modified Bilosomes as Functional and Biocompatible Nanocarriers of Hybrid Compounds

Novel Surface-Modified Bilosomes as Functional and Biocompatible Nanocarriers of Hybrid Compounds

Method Development and Characterization of Liposomal Formulation of Isotretinoin

Chondroitin Sulfate-Modified Liposomes for Targeted Co-Delivery of Doxorubicin and Retinoic Acid to Suppress Breast Cancer Lung Metastasis

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