The Jerusalem artichoke (Helianthus tuberosus L.) is a perennial weed that is cultivated for bioethanol production or pharmaceutical purposes, as its aerial parts and tubers contain several chemical compounds. This review summarizes important data on the effects of the main cultivation practices (e.g., the planting density and pattern, weed management, fertilization, irrigation, genotypes and harvest) on tuber yield and quality. The most widespread method for the propagation of the Jerusalem artichoke is planting the tubers directly in the field, with a plant density of about 33,000–47,000 plants ha−1. Weed management is based on herbicide application, mechanical cultivation and hand hoeing, while the nutrient requirements are low, and irrigation relies on weather conditions. For instance, under Mediterranean semi-arid conditions, the crops are irrigated from June to September. In addition, the harvest time depends on the genotype and the purpose of cultivation, which is an important consideration for obtaining a high-quality product. In conclusion, Jerusalem artichoke yield and quality depend on several factors, and this plant, due to its high productivity, constitutes a promising crop with numerous uses.