Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma

CD39 + tissue-resident memory CD8 + T cells with a clonal overlap across compartments mediate antitumor immunity in breast cancer

“…Most research in tumor immunology has focused on immune cells in the tumor microenvironment (16,(46)(47)(48). However, it is important to know how immune cells in tumor tissues connect to systemic immunity (49)(50)(51). Thus, tracking CD8 + T cell clones across different compartments, including local tissues and peripheral blood, can provide previously unknown insights about systemic antitumor immunity.…”

Standing Watch: Immune Activation and Failure in Melanoma Sentinel Lymph Nodes

“…Activated CD8 + CD69 + cells, however, decrease with metastasis along with a concomitant increase in regulatory T cells, consistent with prior studies. Interestingly, these CD8 + CD69 + T cells might include a population of long-lived, resident T cells, which were recently described to contribute to LN tumor control in mice, and whose LN abundance was associated with outcome in patients (5). Collectively, this shift from activated, protective T cells subsets, to more terminally differentiated T cells is consistent with chronic antigen recognition and progressive immune dysfunction.…”

Multi-scale characterization of tumor-draining lymph nodes in resectable lung cancer treated with neoadjuvant immune checkpoint inhibitors

“…resident memory or progenitor CD8+ T cells have been reported to be the key tumor-specific lymphocytes mediating the anti-tumor immunity. 20 , 22 , 48 Beyond that, growing attention has been recently paid to HEVs that are specialized vessels that allow lymphocyte recirculation through the TDLNs and are indispensable for effective ICI therapy. 19 , 49 , 50 In this study, we discovered that the number and expression (MFI) of HEVs within the TDLNs+ were drastically reduced, compared with TDLNs- ( Figure 6 a, 6 b).…”